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| 1 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 2 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 3 | The Information of Historical Cost Earnings Relative to Supplemental Reserve-Based Accounting Data in the Extractive Petroleum Industry显示文摘 | B Michael Doran Daniel W Collins Dan S Dhaliwal | 1988 | The Accounting Review1988，63，3： | 1 |
| 4 | Cloning and expression of interferon-α/γ from a domestic porcine breed and its effect on classical swine fever virus显示文摘 | Xia C Dan W Wen-Xue W | 2005 | Vet Immunol Immunopathol2005，8189，： | 1 |
| 5 | Expression in Eseheriehia coli and purification of bioactive antibacterial peptide ABP-CM4 from the Chinese silk worm, Bombyx mori 显示文摘 | Li B C Zhang S Q Dan W B | 2007 | Biotechnol Lett2007，29，7： | 1 |
| 6 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11, 105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，13： | 1 |
| 7 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J H | 2012 | Prenatal Diagnosis2012，32，13： | 1 |
| 8 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，13： | 1 |
| 9 | An Automated Method for Analysis of Flow Characteristics of Circulating Particles From In vivo Video Microscopy 显示文摘 | Dan E Dan W Michael R | 2008 | IEEE Transactions on Biomedical Engineering2008，55，1： | 1 |
| 10 | Cross - entropy meas- ure of uncertain variables 显示文摘 | CHEN X W KAR S DAN A R | 2012 | Information Sciences2012，，201： | 1 |
| 11 | Clinical application of massively parallel sequencing-based prenatal non invasive fetal trisomy test for trisomies 21 and ]8 in 11 105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J etal | 2012 | Prenat Diagn2012，32，13： | 1 |
| 12 | Pair Box 8 ( PAX8 ) protein expression in high grade, late stage ( stage III And 1V ) ovarian serous carcinoma显示文摘 | Paulette M F Dan W Damanzoopinder S | 2012 | Gynecol Onco}2012，127，1： | 1 |
| 13 | Cloning and expression of interferon alpha/gamma from a domestic porcine breed and its effect on classical swine fever virus显示文摘 | Xia C Dan W Wen Xue W | 2005 | Vet Immunol Immunopathol2005，104，12： | 1 |
| 14 | Evaluation of 1 - ethyl - 3 - methylimidazolium ace- tate based ionic liquid systems as a suit- able solvent for collagen显示文摘 | Hu Y Liu L Dan W | 2013 | Journal of Applied Polymer Science2013，130，4： | 1 |
| 15 | A new model of diffuse brain injury in rats, Part I: pathophysiology and biomechanics 显示文摘 | Marmarou A Foda MA van dan Brink w | 1994 | J Neurosurg1994，80，2： | 1 |
| 16 | New trie data structures which support very fast search operations 显示文摘 | Dan E W | 1984 | Journal of Computer and System Sciences1984，28，3： | 1 |
| 17 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，： | 1 |
| 18 | Isozyme inheritance and variation in Actindia显示文摘 | Huang H W Dan F Wang Z | 1997 | Heredity1997，78，： | 1 |
| 19 | Response of tree legumes to rhizobial inoculation in relation to the population density of indigenous rhizobia显示文摘 | Dan T Harold H K Paul W S | 1993 | Soil Biology and Biochemistry1993，25，1： | 1 |
| 20 | A Theoretical Review And Empirical Investigation Of Employee Trust In Manage ment显示文摘 | Dan P Mccauley Karl W Kuhnert | 1992 | Paq1992，，7： | 1 |
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