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| 1 | Effects of Two Curcuminoids on Candida albicans显示文摘Objective To investigate and compare the action of curcuminoids on the causal pathogens of Candida albicans growth. Methods The effects of curcumin (CUR) and demethoxycurcumin (DMC) on C. albicans growth were first investigated and compared by microcalorimetry coupled with multiple analytical methods. The quantitative thermo-kinetic parameters obtained from these curves were analyzed to show difference of the actions. Results By analyzing the main parameters screened from principal component analysis together with 50% inhibiting concentration values, it was demonstrated that both CUR and DMC showed good antifungal activities and CUR was stronger. It was further concluded from structure-activity relationship that the existence of methoxy group might enhance lipophilicity of the mother nucleus, which made it easier for the molecular to enter into the cell membrane of fungi to inhibit its growth. Conclusion This study provides a new method for screening new antifungal agents with high efficacy and low toxicity. Meanwhile, it contributes to the application of curcuminoids as food additive, colorant, and drug. Microcalorimetry is real-time, online, and dynamic, and it could be used to characterize the subtle difference among the effects of synthetic and natural products on the vital process of fungi. | ZHANG Da LUO Jiao-yang YAN Dan JIN Cheng DONG Xiao-ping XIAO Xiao-he | 2012 | Chinese Herbal Medicines2012，4，3： | 5 |
| 2 | The Marine Redox Change and Nitrogen Cycle in the Early Cryogenian Interglacial Time: Evidence from Nitrogen Isotopes and Mo Contents of the Basal Datangpo Formation, Northeastern Guizhou, South China显示文摘Cryogenian Datangpo Formation was deposited during the interglacial time between the Sturtian and Marinoan ice ages. We studied nitrogen isotope compositions and contents of Mo of the black shales from the basal Datangpo Formation in northeastern Guizhou, South China, for an attempt to reconstruct the marine redox change and nitrogen cycle during the interglacial time. Based on lithostratigraphy as well as geochemical profiles, the basal black shales can be divided into four intervals: Interval 1 has the lowest δ^(15)N value(+5.0‰); in interval 2, δ^(15)N values vary between +6.4‰ and +7.4‰(the first peak); interval 3 records stable values of δ^(15)N around +6‰; and interval 4 is characterized by its higher δ^(15)N values, between +6.7‰ and +7.8‰(the second peak). The values of enrichment factor of Mo decrease from 56.8 to 2.6 with the ascending stratigraphic trend. It indicated that immediately after the Sturtian glaciations, the marine seawater above the transitional zone between the shelf to slope of the southern margin of the Yangtze Platform was stratified, with shallow seawater being oxic but deep water being sulfidic. Subsequently, high denitrification rates prevailed in expanded suboxic areas in spite of a short emergence of an oxic condition in the surface seawater, and the deep seawaters were still anoxic or even euxinic. | Wei Wei Dan Wang Da Li Hongfei Ling Xi Chen Guangyi Wei Feifei Zhang Xiangkun Zhu Bin Yan | 2016 | Journal of Earth Science2016，27，2： | 3 |
| 3 | Pre-clinical evaluation of a new indirectly labeled 99mTc-6-hydrazinopyridine-3-carboxylic acid (HYNIC)-depreotide with HYNIC as bifunctional chelator显示文摘 | YU Fei LU Ming-li ZHANG Xiao-ping FU Da HOU Min CAI Hai-dong LI Dan WANG Jian YUAN Xue-yu LU Zhong-wei DONG Feng | 2012 | Chinese Medical Journal2012，，14： | 2 |
| 4 | Isolation and Characterization of Recombinant Variable Domain of Heavy Chain Anti-idiotypic Antibodies Specific to Aflatoxin B_1显示文摘Some unique subclasses of Camelidae antibodies are devoid of the light chain,and the antigen binding site is comprised exclusively of the variable domain of the heavy chain(VHH).The recombinant VHHs have a high potential as alternative reagents for the next generation of immunoassay.In particular,they might be very useful for molecular mimicry.The present study demonstrated an alpaca immunized with the F(ab’)2fragment of anti-aflatoxin B1 mAb and developed an important anti-idiotypic(anti-Id)responses.Antigen-specific elution method was used for panning private anti-Id VHHs from the constructed alpaca VHH library.The selected VHHs were expressed,renatured,purified,and then identified by a competitive enzyme-linked immunosorbent assay(ELISA).Our findings indicated that the VHH would be an alternative tool for haptens mimicry studies. | WANG Dan XU Yang TU Zhui FU Jin Heng XIONG Yong Hua FENG Fan TAO Yong LEI Da | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 5 | Influence of red alder on soil nitrogen transformations in two conifer forests of contrasting productivity 显示文摘 | Hart SC Dan B Perry DA | 1997 | Soil Biol Biochem1997，29，7： | 1 |
| 6 | Disruption and protein re- lease by uhrasonication of yeast cells 显示文摘 | DAN L XIN A Z DA W S | 2013 | Innovative Food Science & Emerging Technologies2013，18，： | 1 |
| 7 | Disruptionand protein release by ultrasonication of yeast cells显示文摘 | Dan L Xin A Z Da W | 2013 | Innovative Food Science&Emerging Technologies2013，18，： | 1 |
| 8 | Reductive damage induced autophagy inhibition for tumor therapy显示文摘Numerous therapeutic anti-tumor strategies have been developed in recent decades.However,their therapeutic efficacy is reduced by the intrinsic protective autophagy of tumors.Autophagy plays a key role in tumorigenesis and tumor treatment,in which the overproduction of reactive oxygen species(ROS)is recognized as the direct cause of protective autophagy.Only a few molecules have been employed as autophagy inhibitors in tumor therapy to reduce protective autophagy.Among them,hydroxychloroquine is the most commonly used autophagy inhibitor in clinics,but it is severely limited by its high therapeutic dose,significant toxicity,poor reversal efficacy,and nonspecific action.Herein,we demonstrate a reductive-damage strategy to enable tumor therapy by the inhibition of protective autophagy via the catalytic scavenging of ROS using porous nanorods of ceria(PN-CeO_(2))nanozymes as autophagy inhibitor.The antineoplastic effects of PN-CeO_(2)were mediated by its high reductive activity for intratumoral ROS degradation,thereby inhibiting protective autophagy and activating apoptosis by suppressing the activities of phosphatidylinositide 3-kinase/protein kinase B and p38 mitogen-activated protein kinase pathways in human cutaneous squamous cell carcinoma.Further investigation highlighted PN-CeO_(2)as a safe and efficient anti-tumor autophagy inhibitor.Overall,this study presents a reductive-damage strategy as a promising anti-tumor approach that catalytically inhibits autophagy and activates the intrinsic antioxidant pathways of tumor cells and also shows its potential for the therapy of other autophagy-related diseases. | Yuqian Wang Yingjian Huang Yu Fu Zhixiong Guo Da Chen Fangxian Cao Qi Ye Qiqi Duan Meng Liu Ning Wang Dan Han Chaoyi Qu Zhimin Tian Yongquan Qu Yan Zheng | 2023 | Nano Research2023，16，4： | 1 |
| 9 | Double trisomy in spontaneous miscarriages: cytogenetie and molecular approach 显示文摘 | Dan DA Carmen RC Maria GH | 2006 | Hum Reprod2006，21，4： | 1 |
| 10 | Late onset of sequential multifocal bleb leaks after glaucoma filtration surgery with 5-fluorou-racil and mitomycin C显示文摘 | Belyea DA Dan JA Stamper RL | 1997 | Am J Ophthalmol1997，124，1： | 1 |
| 11 | Midterm follow-up results of combined phacoemulsification, lens implantation andmitomycin-C trabecutectomy procedure 显示文摘 | Belyea DA Dan JA Lieberman MF | 1997 | J Glaucoma1997，6，2： | 1 |
| 12 | Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia 显示文摘 | Fan Chenhao Iacobas DA Zhou Dan | 2005 | Physiol Genomies2005，22，3： | 1 |
| 13 | Late onset of sequential multifocal bleb leaks after glaucoma filtration surgery with 5-fluorouracil and mitomycin C显示文摘 | Belyea DA Dan JA StamperRL | 1997 | Am J Ophthalmol1997，124，： | 1 |
| 14 | Co‑packaged optics(CPO):status,challenges,and solutions显示文摘Due to the rise of 5G,IoT,AI,and high-performance computing applications,datacenter trafc has grown at a compound annual growth rate of nearly 30%.Furthermore,nearly three-fourths of the datacenter trafc resides within datacenters.The conventional pluggable optics increases at a much slower rate than that of datacenter trafc.The gap between application requirements and the capability of conventional pluggable optics keeps increasing,a trend that is unsustainable.Copackaged optics(CPO)is a disruptive approach to increasing the interconnecting bandwidth density and energy efciency by dramatically shortening the electrical link length through advanced packaging and co-optimization of electronics and photonics.CPO is widely regarded as a promising solution for future datacenter interconnections,and silicon platform is the most promising platform for large-scale integration.Leading international companies(e.g.,Intel,Broadcom and IBM)have heavily investigated in CPO technology,an inter-disciplinary research feld that involves photonic devices,integrated circuits design,packaging,photonic device modeling,electronic-photonic co-simulation,applications,and standardization.This review aims to provide the readers a comprehensive overview of the state-of-the-art progress of CPO in silicon platform,identify the key challenges,and point out the potential solutions,hoping to encourage collaboration between diferent research felds to accelerate the development of CPO technology. | Min Tan Jiang Xu Siyang Liu Junbo Feng Hua Zhang Chaonan Yao Shixi Chen Hangyu Guo Gengshi Han Zhanhao Wen Bao Chen Yu He Xuqiang Zheng Da Ming Yaowen Tu Qiang Fu Nan Qi Dan Li Li Geng Song Wen Fenghe Yang Huimin He Fengman Liu Haiyun Xue Yuhang Wang Ciyuan Qiu Guangcan Mi Yanbo Li Tianhai Chang Mingche Lai Luo Zhang Qinfen Hao Mengyuan Qin | 2023 | Frontiers of Optoelectronics2023，16，1： | 1 |
| 15 | Terson's syndrome: areversible cause of blind- ness following subarachnoid hemorrhage 显示文摘 | Garfinkle AM Dans JR Nicolle DA | 1992 | J Neurosurg1992，76，： | 1 |
| 16 | Application of 12S rRNA gene for the identification of animal-derived drugs 显示文摘 | Luo Jiaoyang Yan Dan Zhang Da | 2011 | J Pharm Pharmaceut Sci2011，14，3： | 1 |
| 17 | Substitutes for endan- gered medicinal animal horns and shells exposed by antithrombotic and anticoagulation effects 显示文摘 | Luo Jiaoyang Yan Dan Zhang Da | 2011 | J Ethnopharmacol2011，136，1： | 1 |
| 18 | Synergetic roadmap of carbon neutrality and clean air for China显示文摘It is well recognized that carbon dioxide and air pollutants share similar emission sources so that synergetic policies on climate change mitigation and air pollution control can lead to remarkable co-benefits on greenhouse gas reduction,air quality improvement,and improved health.In the context of carbon peak,carbon neutrality,and clean air policies,this perspective tracks and analyzes the process of the synergetic governance of air pollution and climate change in China by developing and monitoring 18 indicators.The 18 indicators cover the following five aspects:air pollution and associated weather-climate conditions,progress in structural transition,sources,inks,and mitigation pathway of atmospheric composition,health impacts and benefits of coordinated control,and synergetic governance system and practices.By tracking the progress in each indicator,this perspective presents the major accomplishment of coordinated control,identifies the emerging challenges toward the synergetic governance,and provides policy recommendations for designing a synergetic roadmap of Carbon Neutrality and Clean Air for China. | Qiang Zhang Zhicong Yin Xi Lu Jicheng Gong Yu Lei Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Hancheng Dai Zhanfeng Dong Guannan Geng Dabo Guan Jianlin Hu Cunrui Huang Jianing Kang Tiantian Li Wei Li Yongsheng Lin Jun Liu Xin Liu Zhu Liu Jinghui Ma Guofeng Shen Dan Tong Xuhui Wang Xuying Wang Zhili Wang Yang Xie Honglei Xu Tao Xue Bing Zhang Da Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Bo Zheng Yixuan Zheng Tong Zhu Jinnan Wang Kebin He | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
| 19 | Identification of cross-reactive CD8^(+)T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants显示文摘Despite the growing knowledge of T cell responses in COVID-19 patients,there is a lack of detailed characterizations for T cell-antigen interactions and T cell functions.Here,with a predicted peptide library from SARS-CoV-2 S and N proteins,we found that specific CD8+T cell responses were identified in over 75%of COVID-19 convalescent patients(15/20)and an epitope from the N protein,N361-369(KTFPPTEPK),was the most dominant epitope from our selected peptide library.Importantly,we discovered 2 N361-369-specific T cell receptors(TCRs)with high functional avidity that were independent of the CD8 co-receptor.These TCRs exhibited complementary cross-reactivity to several presently reported N361-369 mutant variants,as to the wild-type epitope.Further,the natural functions of these TCRs in the cytotoxic immunity against SARS-CoV-2 were determined with dendritic cells(DCs)and the lung organoid model.We found that the N361-369 epitope could be normally processed and endogenously presented by these different types of antigen presenting cells,to elicit successful activation and effective cytotoxicity of CD8+T cells ex vivo.Our study evidenced potential mechanisms of cellular immunity to SARS-CoV-2,and illuminated potential ways of viral clearance in COVID-19 patients.These results indicate that utilizing CD8-independent TCRs against SARS-CoV-2-associated antigens may provide functional superiority that is beneficial for the adoptive cell immunotherapies based on natural or genetically engineered T cells.Additionally,this information is highly relevant for the development of the next-generation vaccines with protections against continuously emerged SARS-CoV-2 mutant strains. | Chao Hu Meiying Shen Xiaojian Han Qian Chen Luo Li Siyin Chen Jing Zhang Fengxia Gao Wang Wang Yingming Wang Tingting Li Shenglong Li Jingjing Huang Jianwei Wang Ju Zhu Dan Chen Qingchen Wu Kun Tao Da Pang Aishun Jin | 2022 | Genes & Diseases2022，9，1： | 0 |
| 20 | Candidate genes for male and female reproductive traits in Canchim beef cattle显示文摘Background: Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 animals.Results: Associated SNPs were observed for scrotal circumference at 420 d of age(435 SNPs), followed by scrotal circumference at 210 d of age(12 SNPs), age at first calving(six SNPs), and age at second calving(four SNPs). We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and reproduction.Conclusions: Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless,the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, al relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program. | Marcos Eli Buzanskas Daniela do Amaral Grossi Ricardo Vieira Ventura Flavio Schramm Schenkel Tatiane Cristina Seleguim Chud Nedenia Bonvino Stafuzza Luciana Diniz Rola Sarah Laguna Conceio Meirelles Fabiana Barichello Mokry Maurício de Alvarenga Mudadu Roberto Hiroshi Higa Marcos Vinícius Gualberto Barbosa da Silva Maurício Mello de Alencar Luciana Correia de Almeida Regitano Danísio Prado Munari | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 0 |
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