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| 1 | Wrinkled petals and stamens 1,is required for the morphogenesis of petals and stamens in Lotus japonicus显示文摘尽管许多进步在理解花的机关身份怎么在花的发展期间是坚定的被取得了,更少花的机关怎么在晚花的发展阶段被详细描述被知道。这里,我们描述新奇花的异种,起皱的花瓣和 stamens1 (wps1 ) ,它在花瓣和雄蕊的发展显示出缺点。基因分析显示那 wps1 异种相应于在染色体 3 的长手臂的一个单个后退的地点。在 wps1 异种的花的机关的早发展在野类型类似于那,并且异种的 malfunction 在晚发展的阶段开始,显示花瓣和雄蕊的外观上的一个缺点。在成熟的花,在异种的花瓣和雄蕊细丝被起皱或合拢,并且在花瓣和雄蕊细丝的 L1 层下面的细胞的形态学是反常的。花的机关身份基因的表达式模式没与野类型的相比在 wps1 异种被影响,这被发现,与所有花的机关的未改变的开发一致。而且,在花瓣的不同类型的表皮的房间的身份被维持。组织学的分析证明在 wps1 花,所有花瓣不规则地被合拢,并且在花瓣有系的结构,当内部房间的形状和安排畸形、未组织起来时。把结果基于这些,我们建议 Wps1 下游地行动到班 B 花的机关身份基因,并且工作在迟了的花期间调制细胞的区别发展阶段。 | Jiang Hua Chen Ji Liang Pang Li Lin Wang Yong Hai Luo Xin Li Xiang Ling Cao Kui Lin Wei Ma Xiao He Hu Da Luo | 2006 | Cell Research2006，16，5： | 4 |
| 2 | Synthesis,structure and optical properties of novel thermally robust Dy^(3+)-doped Ca_(9)Sc(PO_(4))_(7) phosphors for NUV-excited white LEDs显示文摘The powder samples of Ca_(9)Sc(PO_(4))_(7):xDy^(^(3+))white emitting phosphors were prepared via a solid state reaction technique.The Ca_(9)Sc(PO_(4))_(7):Dy^(3+)samples were researched by using the GSAS Rietveld refinement and X-ray diffraction(XRD) methods,and SEM images and elemental maps were recorded.Under 350 nm excitatio n,the emission spectra of Ca_(9)Sc(PO_(4))_(7):xDy^(3+)samples have two obvious peaks and one weak peak at 484,572 and660 nm,corresponding to the characteristic electron transitions of(^(4)F_(9/2)→ ^(6)H_(15/2),blue),(^(4)F_(9/2)→ ^(6)H_(13/2),yellow) and(^(4)F_(9/2)→ 6 H11/2,red),respectively.The concentration quenching effect,decay lifetime and thermal quenching of the as-synthesized Ca_(9)Sc(PO_(4))_(7):Dy^(3+)samples were researched systematically.The Ca_(9)Sc(PO_(4))_(7):0.02 Dy^(3+)phosphor possesses a good thermal stability,of which the emission intensity at 423 K can maintain 79% of the initial value(273 K).In addition,through the study of the chro maticity coordinates of the Ca_(9)Sc(PO_(4))_(7):0.02 Dy^(3+)phosphor,it is found that it is located in the white region,and the Commission Internationalede L’Eclairage(CIE) chromaticity coordinates are(0.339,0.389),The above results show that Ca_(9)Sc(PO_(4))_(7):xDy^(3+)phosphors can be excellent candidate material for applications in NUV-excited white LEDs. | Haiyan Wu Huimin Li Lihong Jiang Ran Pang Su Zhang Da Li Guanyu Liu Chengyu Li Jing Feng Hongjie Zhang | 2021 | Journal of Rare Earths2021，39，3： | 4 |
| 3 | Cyclooxygenase (COX) inhibitors induce apoptosis in nonsmall cell lung cancer through cyclooxygenase in-dependent pathways显示文摘 | Bradbury DA Pang L | 2003 | Lung Cancer2003，40，： | 1 |
| 4 | Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways显示文摘 | Sanchez-Alcazar JA Bradbury DA Pang L | 2003 | Lung Cancer2003，40，1： | 1 |
| 5 | Partial inverse PCR: a technique for cloning flanking sequences显示文摘 | Pang KM Knecht DA | 1997 | Biotechniques1997，22，6： | 1 |
| 6 | Intelligent structured nanocomposite adhesive for bioelectronics and soft robots显示文摘The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced features.This review focuses on intelligent bio-inspired strategies for developing soft bioelectronics and robotics that can accommodate nanocomposite adhesives and integrate them into biological surfaces.The underlying principles of the material and structural design of nanocomposite adhesives were investigated for practical applications with excellent functionalities,such as soft skin-attachable health care sensors,highly stretchable adhesive electrodes,switchable adhesion,and untethered soft robotics.In addition,we have discussed recent progress in the development of effective fabrication methods for micro/nanostructures for integration into devices,presenting the current challenges and prospects. | Yeon Soo Lee Min-Seok Kim Da Wan Kim Changhyun Pang | 2024 | Nano Research2024，17，2： | 1 |
| 7 | Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways显示文摘 | Sanchez-Alcazar JA Bradbury DA Pang L | 2003 | Lung Cancer2003，40，1： | 1 |
| 8 | Cyclooxygenase (COX) inhibitors induce apoptosis in nonsmall cell lung cancer through cyclooxygenase independent pathways显示文摘 | Sanchez - Alcazar JA Bradbury DA Pang L | 2003 | Lung Cancer2003，40，1： | 1 |
| 9 | Cyclooxygenase(COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways显示文摘 | Bradbury DA Pang L | 2003 | Lung Cancer2003，40，1： | 1 |
| 10 | Controllable conversion of rice husks to Si/C and SiC/C composites in molten salts显示文摘Direct conversion of biomass to functional materials is an ideal solution to relieve challenges in environmental and energy sustainability.We herein demonstrate a molten salt thermoelectrolysis of rice husks(RHs)mainly consisting of organic mass and biosilica to achieve high-efficiency and upgraded utilization of both Si and C in RHs.By coupling pyrolysis of organic mass with electrochemical reduction of silica in molten salts,the thermoelectrolysis of RHs in molten CaCl_(2)-NaCl at 800℃ refines the RHs and acidleached RHs to SiC nanowire/C(SiC-NW/C)and Si nanoparticle/C(Si-NP/C),respectively.The present study highlights the molten salt thermoelectrolysis for reclamation of biomass wastes in an affordable and controllable manner. | Da Pang Wei Weng Jing Zhou Dong Gu Wei Xiao | 2021 | Journal of Energy Chemistry2021，30，4： | 1 |
| 11 | Cyclooxygenase(COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways显示文摘 | Sanchez A Bradbury DA Pang L | 2003 | Lung Cancer2003，40，1： | 1 |
| 12 | Cyclooxygenase(Cox) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxyenase independent pathways显示文摘 | Sanchez-Aldazar JA Bradbury DA Pang L | 2003 | Lung Cancer2003，40，1： | 1 |
| 13 | Decomposing the roles of perse- veration and expected value representation in models of the Io- wa gambling task显示文摘 | Worthy DA Pang B Byrne KA | 2013 | Front Psychol2013，4，4： | 1 |
| 14 | Cyclooxygenase (COX) inhlbltors induce apoptosis in non-small cell lung cancer through cyclooxygenase in-dependent pathways显示文摘 | Sanchez-Alcazar JA Bradbury DA Pang L | 2003 | Lung Cancer2003，40，： | 1 |
| 15 | Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways显示文摘 | Sanchez-Alcazar JA Bradbury DA Pang L | 2003 | Lung Cancer2003，，： | 1 |
| 16 | Diagnosis of foregut and tailgut cysts by endosonographically guided fine-needle aspiration显示文摘 | HALL DA PU RT PANG Y | 2007 | Di- agn Cytopathol2007，35，1： | 1 |
| 17 | Identification of cross-reactive CD8^(+)T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants显示文摘Despite the growing knowledge of T cell responses in COVID-19 patients,there is a lack of detailed characterizations for T cell-antigen interactions and T cell functions.Here,with a predicted peptide library from SARS-CoV-2 S and N proteins,we found that specific CD8+T cell responses were identified in over 75%of COVID-19 convalescent patients(15/20)and an epitope from the N protein,N361-369(KTFPPTEPK),was the most dominant epitope from our selected peptide library.Importantly,we discovered 2 N361-369-specific T cell receptors(TCRs)with high functional avidity that were independent of the CD8 co-receptor.These TCRs exhibited complementary cross-reactivity to several presently reported N361-369 mutant variants,as to the wild-type epitope.Further,the natural functions of these TCRs in the cytotoxic immunity against SARS-CoV-2 were determined with dendritic cells(DCs)and the lung organoid model.We found that the N361-369 epitope could be normally processed and endogenously presented by these different types of antigen presenting cells,to elicit successful activation and effective cytotoxicity of CD8+T cells ex vivo.Our study evidenced potential mechanisms of cellular immunity to SARS-CoV-2,and illuminated potential ways of viral clearance in COVID-19 patients.These results indicate that utilizing CD8-independent TCRs against SARS-CoV-2-associated antigens may provide functional superiority that is beneficial for the adoptive cell immunotherapies based on natural or genetically engineered T cells.Additionally,this information is highly relevant for the development of the next-generation vaccines with protections against continuously emerged SARS-CoV-2 mutant strains. | Chao Hu Meiying Shen Xiaojian Han Qian Chen Luo Li Siyin Chen Jing Zhang Fengxia Gao Wang Wang Yingming Wang Tingting Li Shenglong Li Jingjing Huang Jianwei Wang Ju Zhu Dan Chen Qingchen Wu Kun Tao Da Pang Aishun Jin | 2022 | Genes & Diseases2022，9，1： | 0 |
| 18 | HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province,China,2014–2020显示文摘Objective This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance(HIVDR)in patients with ART failure from 2014 to 2020 in Hainan,China.Methods A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in Hainan.We used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with pol sequences.Drug resistance mutations(DRMs)were analyzed using the Stanford University HIV Drug Resistance Database.Results A total of 307 HIV-infected patients with ART failure were included,and 241 available pol sequences were obtained.Among 241 patients,CRF01_AE accounted for 68.88%,followed by CRF07_BC(17.00%)and eight other subtypes(14.12%).The overall prevalence of HIVDR was 61.41%,and the HIVDR against non-nucleoside reverse transcriptase inhibitors(NNRTIs),nucleotide reverse transcriptase inhibitors(NRTIs),and protease inhibitors(PIs)were 59.75%,45.64%,and 2.49%,respectively.Unemployed patients,hypoimmunity or opportunistic infections in individuals,and samples from 2017 to 2020 increased the odd ratios of HIVDR.Also,HIVDR was less likely to affect female patients.The common DRMs to NNRTIs were K103N(21.99%)and Y181C(20.33%),and M184V(28.21%)and K65R(19.09%)were the main DRMs against NRTIs.Conclusion The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period. | YU De E XU Yu Jun LI Mu YANG Yuan LIANG Hua Yue ZHONG Shan Mei QIN Cai LAN Ya Nan LI Da Wei YU Ji Peng PANG Yuan QIN Xue Qiu LIANG Hao ZHU Kao Kao YE Li LIANG Bing Yu | 2023 | Biomedical and Environmental Sciences2023，36，9： | 0 |
| 19 | Single-phase white-emitting and tunable color phosphor Na_(3)Sc_(2)(PO_(4))_(3):Eu^(2+),Dy^(3+): Synthesis, luminescence and energy transfer显示文摘A series of Eu^(2+)/Dy^(3+) single doped and co-doped Na_(3)Sc_(2)(PO_(4))_(3) phosphors were synthesized by the high-temperature solid-state method,and their phase,morphology,and luminescence properties were characterized.Under the excitation of 370 nm,the Na_(3)Sc_(2)(PO_(4))_(3):Eu^(2+),Dy^(3+) phosphor can emit white light whose spectrum is composed of a broad emission band centered at 460 nm and the other three peaks at 483,577,and 672 nm,respectively.There is energy transfer from Eu^(2+)to Dy^(3+)ion in Na_(3)Sc_(2)(PO_(4))_(3):Eu^(2+),Dy^(3+) phosphor due to the good overlap between the emission spectrum of Na_(3)Sc_(2)(PO_(4))_(3):Eu^(2+) and the excitation spectrum of Na_(3)Sc_(2)(PO_(4))_(3):Dy^(3+),which is further confirmed by the fluorescence lifetime decrease of Eu^(2+)ion with the increase of Dy^(3+) concentration.The process of energy transfer is via dipole–quadruple interaction which is confirmed by applying Dexter's theory.By increasing the Dy^(3+)concentration,the color coordinates of the Na_(3)Sc_(2)(PO_(4))_(3):0.01Eu^(2+),xDy^(3+)phosphors can be adjusted from blue to white,and then to yellow.The optimized concentration of Dy^(3+)ions is 4.0 mol%,beyond which the concentration quenching will take place.The Na_(3)Sc_(2)(PO_(4))_(3):Eu^(2+),Dy^(3+)phosphor shows fairly good resistance to thermal quenching behavior,of which the emission intensity at 423 K can maintain 90.3%of the initial value(298 K).These results suggest that the Na_(3)Sc_(2)(PO_(4))_(3):0.01Eu^(2+),xDy^(3+)phosphors have potential applications as the color-tunable or a single-phase white emitting phosphor in white LEDs. | Sen Wang Haiyan Wu Xin Wen Yanqing Luo Tao Tan Shengjian Jiao Ran Pang Lihong jiang Su Zhang Da Li Guanyu Liu Chengyu Li Hongjie Zhang | 2022 | Journal of Rare Earths2022，40，4： | 0 |
| 20 | Noncoding RNAs:the shot callers in tumor immune escape显示文摘Immunotherapy,designed to exploit the functions of the host immune system against tumors,has shown considerable potential against several malignancies.However,the utility of immunotherapy is heavily limited due to the low response rate and various side effects in the clinical setting.Immune escape of tumor cells may be a critical reason for such low response rates.Noncoding RNAs(ncRNAs)have been identified as key regulatory factors in tumors and the immune system.Consequently,ncRNAs show promise as targets to improve the efficacy of immunotherapy in tumors.However,the relationship between ncRNAs and tumor immune escape(TIE)has not yet been comprehensively summarized.In this review,we provide a detailed account of the current knowledge on ncRNAs associated with TIE and their potential roles in tumor growth and survival mechanisms.This review bridges the gap between ncRNAs and TIE and broadens our understanding of their relationship,providing new insights and strategies to improve immunotherapy response rates by specifically targeting the ncRNAs involved in TIE. | Lei Liu Qin Wang Zhilin Qiu Yujuan Kang Jiena Liu Shipeng Ning Yanling Yin Da Pang Shouping Xu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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