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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | Psychosocial determinants of irritable bowel syndrome显示文摘From a pure motor disorder of the bowel,in the past few years,irritable bowel syndrome (IBS) has become a multifactorial disease that implies visceral hypersensitivity,alterations at the level of nervous and humoral communications between the enteric nervous system and the central nervous system,alteration of the gut microflora,an increased intestinal permeability and minimum intestinal inflammation.Psychological and social factors can interfere with the communication between the central and enteric nervous systems,and there is proof that they are involved in the onset of IBS and influence the response to treatment and outcome.There is evidence that abuse history and stressful life events are involved in the onset of functional gastrointestinal disorders.In order to explain clustering of IBS in families,genetic factors and social learning mechanisms have been proposed.The psychological features,such as anxiety,depression as well as the comorbid psychiatric disorders,health beliefs and coping of patients with IBS are discussed in relation to the symptoms and outcome. | Teodora Surdea-Blaga Adriana Bban Dan L Dumitrascu | 2012 | World Journal of Gastroenterology2012，18，7： | 34 |
| 3 | Corrigendum to “Properties improvement of SPEEK based proton exchange membranes by doping of ionic liquids and Y_2O_3”[Prog. Nat. Sci.: Mater. Int. 22 (1) (2012) 26-30] | Jianbin Chen a, Qiang Guo a, Dan Li a, Juying Tong a,b, Xia Li a a School of Materials Science and Engineering, Shanghai University, Shanghai 201800, China b School of Wenling, Zhejiang TV University, Wenling 317500, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 33 |
| 4 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 5 | Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies显示文摘Gastrointestinal cancers represent a major cause of morbidity and mortality,with incomplete response to chemotherapy in the advanced stages and poor prognosis.Angiogenesis plays a crucial part in tumor growth and metastasis,with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary network.Confocal laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast agents.Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination(immunoendoscopy),as a future challenge,will add functional analysis to the morphological aspect of the neoplastic process.This review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization,resulting in a broad spectrum of potential clinical applications,and also preclinical research that could be translated to human studies. | Dan Ionut Gheonea Tatiana Crtnǎ Tudorel Ciurea Carmen Popescu Anca Bǎdǎrǎu Adrian Sǎftoiu | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 6 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 7 | 考虑振动响应的刚柔耦合悬臂梁动力学建模与数值仿真显示文摘建立合理的刚柔耦合系统动力学模型是实现碰撞冲击动态响应分析的基础。利用假设模态法描述了悬臂梁的振动位移响应,在此基础上基于广义坐标建立了系统的运动链。同时考虑悬臂梁的横向振动与纵向振动响应,在计入柔性杆横向弯曲变形引起轴向拉伸变形的2阶耦合量的条件下,分别基于Kane方法和Lagrange方法推导了刚柔耦合悬臂梁系统动力学方程,通过数值仿真揭示了系统广义坐标或速度的时变规律。仿真结果表明:两种方法下具有相同意义广义坐标的时变规律完全吻合。采用3D高速摄像机用于捕获悬臂梁的运动以验证构建模型的有效性。试验测试结果表明:试验测试值与仿真模拟值的误差值均小于5%,试验结果与模拟结果相符,说明动力学模型与计算方法均有效可行。研究结果可为接触面碰撞冲击理论计算及试验验证提供参考。 | 王尧 孟文俊 Dan B Marghitu 李淑君 | 2018 | 机械设计2018，35，9： | 2 |
| 8 | The Information of Historical Cost Earnings Relative to Supplemental Reserve-Based Accounting Data in the Extractive Petroleum Industry显示文摘 | B Michael Doran Daniel W Collins Dan S Dhaliwal | 1988 | The Accounting Review1988，63，3： | 1 |
| 9 | Collusion-secure fingerprinting for digital data显示文摘 | Dan B Janes S | 1995 | IEEE Transactions on Information Theory1995，44，5： | 1 |
| 10 | Nitrogen managemen strategies to nitrate leaching in tile-drained Mid- western soils 显示文摘 | Dana L D Douglas L K Dan B J | 2002 | Agronomy Journal2002，94，： | 1 |
| 11 | Free Trade, Growth, and Convergence 显示文摘 | Ben-David Dan & Loewy Michael B | 1998 | Economic Growth1998，3，2： | 1 |
| 12 | Expression in Eseheriehia coli and purification of bioactive antibacterial peptide ABP-CM4 from the Chinese silk worm, Bombyx mori 显示文摘 | Li B C Zhang S Q Dan W B | 2007 | Biotechnol Lett2007，29，7： | 1 |
| 13 | Coordinating a dual-channel supply chain with risk-averse under a two-way revenue sharing contract显示文摘 | Xu G Dan B Zhang X | 2014 | Int J of Production Economics2014，147，1： | 1 |
| 14 | Pricing policies in a dual-channel supply chain with retail services 显示文摘 | Dan B Xu G Liu C | 2012 | International Journal of Production Economies2012，139，1： | 1 |
| 15 | Quantitative immunohistochemistry by measuring cumulative signal strength using commercially available software photoshop and matlab 显示文摘 | Kristina A Matkowskyja B Dan Schonfeldc SA | 2000 | J Histochem Cytochem2000，48，5： | 1 |
| 16 | Angelman syndrome:Current understanding and research prospects显示文摘 | Dan B | | 0，，11： | 1 |
| 17 | Improved assessment of mass concrete dams using acoustic travel time tomography :part Ⅰ -theory 显示文摘 | LEONARD J B WILLIAM F K DAN M F | 2000 | Construction and Building Materials2000，14，3： | 1 |
| 18 | Different neutralization efficiency of neutralizing monoelonal antibodies against avian influenza H5Nl virus to virus strains from different hosts显示文摘 | HUANG H L DAN H B ZHOU Y J | 2007 | Molecular Immunology2007，44，： | 1 |
| 19 | Paediatric neurology: a year of DNA technology显示文摘 | Dan B Baxter P | 2014 | Lancet Neurol2014，13，： | 1 |
| 20 | 查看详情显示文摘 | Zhang J Chu T S Dong S L Yuan S P Fu A E Dan Y B | | 0，，： | 1 |
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