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| 1 | Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery: a retrospective study显示文摘Background:Following combat-related,extensive soft tissue injury from gunshot wounds or blasts,prolonged duration from injury to full wound closure is associated with infection,increased morbidity and mortality,failure to mobilize,poor functional outcome and increased cost.The purpose of this study was to evaluate a novel treatment enabling early primary closure of combat wounds.Methods:This was a retrospective study of 10 soldiers and civilians with extensive combat-related soft tissue limb injuries(5 gunshot wounds,5 blasts)treated using the TopClosure^(■)Tension Relief System(TRS)with simultaneous administration of regulated oxygen-enriched and irrigation negative pressure-assisted wound therapy(ROINPT)via the Vcareα^(■)device.Results:Nine patients were treated during the acute phase of injury and one was treated following removal of a flap due to deep infection 20 years after injury and flap reconstruction.Two patients had upper limb injury and the rest lower limb injury.With the aid of the TRS and/or ROINPT,immediate primary closure during reconstruction was achieved in 6 patients and delayed primary closure in three.Only one patient required a skin graft to close a small area of the wound after most of the wound had been closed by delayed primary closure.Wound closure was achieved within 0–37 days(median:12.5 days,interquartile range:2.75–19.75)from injury.Conclusions:The TRS is a novel device for effective,early skin stretching and secure wound closure through the application of stress relaxation and mechanical creep,achieving primary closure of large defects using a simplified surgical technique and reducing the need for closure using skin grafts and flaps and the use of tissue expanders.Delivering supplemental oxygen to the wound by ROINPT reverses the reduced oxygen levels inherent in conventional negative pressure-assisted wound therapy,mitigating anaerobic contamination and reducing infection.Irrigation may accelerate the evacuation of infectious material from the wound and provide a novel method for antibiotic administration.The combination of TRS and ROINPT devices allow for early primary closure with improved functionality of combat-related limb injuries. | Moris Topaz Itamar Ashkenazi Oren Barzel Seema Biswas Dan Atar Nurit Shadmi Itzhak Siev-Ner | 2021 | Burns & Trauma2021，9，1： | 7 |
| 2 | Monitoring platelet inhibition after clopidogrel with the Verify Now -P2Y12? rapid analyzer: The VERIfy Thrombosis risk ASsessment (VERITAS) study显示文摘 | Alex Malinin Alex Pokov Malcolm Spergling Anthony Defranco Kenneth Schwartz Dianne Schwartz Ehtisham Mahmud Dan Atar Victor Serebruany | 2006 | Thrombosis Research2006，，： | 1 |
| 3 | The association between meteorological events and acute heart failure: New insights from ASCEND-HF显示文摘 | Debraj Das Jeffery A. Bakal Cynthia M. Westerhout Adrian F. Hernandez Christopher M. O’Connor Dan Atar John J.V. McMurray Paul W. Armstrong Justin A. Ezekowitz | 2014 | International Journal of Cardiology2014，，3： | 1 |
| 4 | CODE-EHR:临床研究中运用结构化电子医疗记录的最佳实践框架显示文摘改善患者生存质量是全球临床医学的发展目标,大数据是实现其发展的关键所在。技术进步使结构化电子医疗记录得以常规化,也可能会改善缺失重要临床证据的问题。虽然大数据及其相关分析在新冠大流行期间发挥了重要作用,但也存在严重的缺陷。证实、核验、数据隐私以及对科学研究社会责任的践行是一项重要挑战。欧洲心脏病协会和BigData@Heart联盟已经收集了包括患者代表、临床医生、科研人员、监管机构、期刊编辑和企业代表在内的多元化国际参与者,提出了CODE-EHR的最低标准框架。为改进研究设计、提高信息透明度提供方法手段,同时为实现医疗保健数据的稳健并能够有效运用制定了技术路线图。 | Dipak Kotecha Folkert W Asselbergs Stephan Achenbach Stefan DAnker Dan Atars Colin Baigent Amitava Banerjee Birgit Beger Cunnar Brobert Barbara Casadei Cinzia Ceccarelli Martin R Cowie Filippo Crea Maureen Cronin Spiros Denaxas Andrea Derix Donna Fitzsimons Martin Fredriksson Chris PGale Georgios V Ckoutos Wim Goettsch Harry Hemingway Martin Ingvaris Adrian Jonas's Robert Kazmierski Susanne Logstrup R Thomas Lumbers Thomas F Lischer Paul McGreavy leana L Pina Lothar Roesiga Carl Steinbeisser Mats Sundgren Benoit Tyl Chislaine van Thiel Kees van Bochove Panos EVardas Tiago Villanueva Marilena Vrana Wim Weber Franz Weidinger Stephan Windecker Angela Wood Diederick E Grobbee 创新药物计划BigData@Heart联盟 欧洲心脏病协会 CODE-EHR国际共识小组 宋奇繁(译) 汪奕名(译) | 2022 | 英国医学杂志中文版2022，25，12： | 0 |
| 5 | 心肌梗死患者应当吸氧吗?根据生理机制并且没有吸氧有害的证据:应该吸氧显示文摘近期发表的一篇系统性综述显示,吸氧不能减轻急性心肌梗死患者的胸痛症状或改善其生存率,反而可能有害。毫无疑问,这一结论会引起医学界的关注,但这篇文章的研究结果是否可靠,它对临床实践又有何意义,值得深入分析。 | Dan Atar 杜昕(译) | 2010 | 英国医学杂志中文版2010，13，6： | 0 |
| 6 | 心肌梗死的新定义——心肌梗死新亚型特征和诊断检测的高要求显示文摘急性心肌梗死定义的演变是医学发展史的一个精彩故事。从1979年世界卫生组织公布最初分类到2000年美国心脏病学会、美国心脏病协会和欧洲心脏病学会重新定义委员会公布了新的分类,诊断理念发生很大改变。现在,生物化学占据了这个舞台的中心,心肌肌钙蛋白的检测明显地增强了诊断敏感性。 | Dan Atar 杨镓宁(译) 戴耕武(校) 乔树宾(校) | 2009 | 英国医学杂志中文版2009，12，2： | 0 |
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