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| 1 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 2 | 'Step-up'or'step-down'in small stente d vessels does not adversely impact clin ical outcome显示文摘 | Kim MH Ziada K Defranco A et a l | 1997 | J Am Coll Cardiol1997，，： | 1 |
| 3 | Assessment of oral implant mobility显示文摘 | Chavez H Ortman LF DeFranco RL | 1993 | J Prosthet Dent1993，70，5： | 1 |
| 4 | Chinese cultural values: Their implications for travel and tourism marketing 显示文摘 | Mok C Defranco A | 2000 | Journal of Travel & Tourism Marketing2000，8，2： | 1 |
| 5 | Photolithographic patterning of organic electronic materials显示文摘 | Schmidt Bradley S Lipson Michal | 2006 | Organic Electronics2006，7，： | 1 |
| 6 | Improving the screening accu-racy for preterm labor:is the combination of fetal fibronectin and cervical length in symptomatic patients a useful predictor of preterm birth? A systematic review 显示文摘 | DeFranco EA Lewis DF Odibo AO | 2013 | Am J Obstet Gynecol2013，208，3： | 1 |
| 7 | The role of tyrosine ki nases and map kinases in LPS-induced signaling显示文摘 | DeFranco AL Crowley MT Finn A | 1998 | Prog Clin Biol Res1998，397，： | 1 |
| 8 | Lipid rafts and B cell signaling显示文摘 | Gupta N Defranco AL | 2007 | Semin Cell Dev Biol2007，18，5： | 1 |
| 9 | Short interpregnancy in- terval: Risk of uterine rupture and complications of vaginal birth after Cesarean delivery 显示文摘 | Stamilio D DeFranco E Para E | 2007 | Obstet Gynecol2007，110，： | 1 |
| 10 | The relative proportion of preterm births complicated by premature rupture of membranes in mul- tifetal gestations : a population-based study 显示文摘 | Pakrashi T Defranco EA | 2013 | Am J Peri- natol2013，30，1： | 1 |
| 11 | Serum PBDEs and age at menarche in adolescent girls:analysis of the national health and nutrition examination survey 2003-2004 显示文摘 | Chen A Chung E DeFranco EA | 2011 | Environ Res2011，111，： | 1 |
| 12 | Cell adhesion regulates platelet-defived growth factor-induced MAP kinase and PI-3 kinase activation in stellate cells 显示文摘 | Carloni V Defranco RM Caligiuri A | 2002 | Hepatology2002，36，3： | 1 |
| 13 | Evaluation and management of valgus impacted four - part proximal humerus fractures 显示文摘 | DeFranco M J Brems JJ Williams GR Jr | 2006 | Clin Orthop Relat Res2006，，442： | 1 |
| 14 | Vaginal progesterone is associat- ed with a decrease in risk for early preterm birth and improved neo- natal outcome in women with a short cervix: a secondary analysis from a randomized, double - blind, placebo - controlle trial 显示文摘 | DEFRANCO E A O BRIEN J M | 2007 | Ultrasound Obstet Gynecol2007，30，5： | 1 |
| 15 | Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages显示文摘 | WEINSTEIN S L GOLD M R DEFRANCO A L | 1991 | Proc Natl Acad Sci USA1991，88，10： | 1 |
| 16 | Association between blood glucose and long-term mortality in patients with acute coronary syndromes in the OPUS-TIMI 16 trial 显示文摘 | BHADRIRAJU S RAY K K DEFRANCO A C | 2006 | Am J Cardiol2006，97，： | 1 |
| 17 | Association between blood glucose and long-term mortality in patients with acute coronary syndromes in the OPUS-TIMI 16 trial显示文摘 | Bhadriraju S Ray KK DeFranco AC | 2006 | Am J Cardiol2006，97，11： | 1 |
| 18 | Photolithographic patterning of highly conductive PEDOT∶PSS and its application in organic lightemitting diodes显示文摘 | Ouyang S Xie Y Wang D Zhu D Xu X Tan T DeFranco J Fong H H | 2014 | Journal of Polymer Science Part B:Polymer Physics2014，52，18： | 1 |
| 19 | Defective function of Fas in T cells from paediatric patients with autoimmune thyroid diseases显示文摘 | Defranco S Cliocchetti A | 2003 | Clin Exp Immunol2003，133，3： | 1 |
| 20 | Cooperativity and complementarity: synergies in non-classical and classical glucocorticoid signaling显示文摘 | Samarasinghe RA Witchell SF DeFranco DB | 2012 | Cell Cycle2012，11，15： | 1 |
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