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| 1 | The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges显示文摘The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory strategies.Synthetic and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric carbon.The participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,Richard J.Roberts,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and adaptation.These include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed. | Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly Richard J.Roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang | 2020 | BioDesign Research2020，，1： | 2 |
| 2 | 全球尺度过量氮元素输入的土壤功能响应显示文摘很少证据显示南半球大陆高度风化、低磷、酸性土壤中氮(N)循环与北美和欧洲有很大的差别。来自南半球的证据表明:不同的土地利用方式中,氮损失的形态和时间模式有相似性;不同大陆林地地表/枯枝落叶层的碳氮比(C:N)对于全球尺度上一系列过程有强烈的预示性;根据北半球增施氮对'受磷制约'的生态系统影响的归纳很可能不适用于南半球生态系统,当地植物结构上和生理上对低磷土壤的适应使得磷制约概念变得可疑;大大地增加了氮的输入和周转的土地利用变化很可能是南半球生态系统的最大威胁;局部氮施入的增加很可能与北半球观测到的效果相似。 | Mark Adams Phil Ineson Dan Binkley Georg Cadisch Naoko Tokuchi Mary Scholes Kevin Hicks 孙会首(译) | 2004 | AMBIO-人类环境杂志2004，33，B12： | 2 |
| 3 | Understanding Uncontrolled Hypertension: Is It the Patient or the Provider?显示文摘 | Adam J.Rose Dan R.Berlowitz Michelle B.Orner Nancy R.Kressin | 2007 | The Journal of Clinical Hypertension2007，，： | 1 |
| 4 | Client perceptions of the MUSCSEL project: a community-based physical activity programme for patients with mental heahh problems 显示文摘 | Ron Butterly Dan Adams Andy Brown Jim Golby | 2006 | Journal of Public Mental Health2006，8，： | 1 |
| 5 | Blind deconvolution of ultrasound sequences using nonparametric local polynomial estimates of the pulse显示文摘 | Dan Adam Oleg Michailovich | 2002 | IEEE Transactions on Biomedical Engineering2002，49，2： | 1 |
| 6 | Soilless media: Practices make profit显示文摘 | Shannen Ferry Ron Adams Dan Jacques | 1998 | Greenhouse Grower1998，，9： | 1 |
| 7 | Soilless media: Pracrices make profit显示文摘 | Shannen Ferry Ron Adams Dan Jacques | 1998 | Greenhouse grower1998，，9： | 1 |
| 8 | The influence of isoflurane on the synaptic activity of 5-hydroxytryptamine显示文摘 | Dan C. Martin Robert J. Adams Robert S. Aronstam | 1990 | Neurochemical Research1990，，10： | 1 |
| 9 | Characterizing Alzheimer’s disease using a hypometabolic convergence index显示文摘 | Kewei Chen Napatkamon Ayutyanont Jessica B.S. Langbaum Adam S. Fleisher Cole Reschke Wendy Lee Xiaofen Liu Dan Bandy Gene E. Alexander Paul M. Thompson Leslie Shaw John Q. Trojanowski Clifford R. Jack Susan M. Landau Norman L. Foster Danielle J. Harvey Mi | 2011 | Neuroimage2011，，1： | 1 |
| 10 | 异丙酚降低帕金森病患者丘脑下核神经元放电活动显示文摘背景治疗帕金森病患者时,通常采用微电极记录仪(microelectrode recording,MER)记录丘脑下核(subthalamic nucleus,STN)神经元峰电位活动来指导实施在STN植入深部脑刺激(deep brain stimulation,DBS)电极。镇静药物对丘脑下核的微电极记录干扰程度如何目前仍不清楚。本研究监测了异丙酚镇静期间丘脑下核神经元放电活动,及对神经元电活动的影响。方法选择需要进行深部脑电刺激手术的帕金森病患者,固定电极定位于丘脑下核部位,给患者静脉输注异丙酚50μg·kg^-1·mm^-1,直到患者处于稳定镇静期。记录神经元电活动,计算异丙酚输注前、中、后神经元电活动的均方根(root mean square,RMS)。结果16例患者中记录了24次电极轨迹的活动,异丙酚注射后其中18次出现明显的丘脑下核电活动的均方根降低。异丙酚输注期间,平均均方根降低23.2%±9.1%(均数±标准差)(P〈0.001),停止输注后回到基线时间为(9.3±4.0)分钟。结论异丙酚输注导致丘脑下核神经峰电活动显著降低,说明它可能干扰丘脑下核边缘微电极记录电活动的识别。停止异丙酚输注后,神经元电活动很快恢复到基线,因此,异丙酚在微电极记录仪指导DBS前可安全地使用。 | Aeyal Raz, MD, PhD Dan Eimerl, MD Adam Zaidel, MSc Hagai Bergman, MD, PhD Zvi Israel, MD 吴德华(译) 曹晖(校) 徐美英(校) | 2012 | 麻醉与镇痛2012，8，3： | 1 |
| 11 | Dreict RNA sequencing 显示文摘 | Fatih O Adam R P Dan R J | 2009 | Nature2009，461，： | 1 |
| 12 | Biodiversity conser- vation and eradication of poverty 显示文摘 | Adams W M Ros A Dan D | 2004 | Science2004，306，： | 1 |
| 13 | Markdown Pricing with Unknown Fraction of Strategic Customers显示文摘 | Adam J. Mersereau Dan Zhang | 2012 | Manufacturing & Service Operations Management2012，，3： | 1 |
| 14 | Robotic-Assisted Laparoscopic Intracorporeal Urinary Diversion显示文摘 | Raj S. Pruthi Jeff Nix Dan McRackan Adam Hickerson Matthew E. Nielsen Matthew Raynor Eric M. Wallen | 2010 | European Urology2010，，6： | 1 |
| 15 | Regulation of cardiac myocyte contractile function by inducible nitric oxide synthase (iNOS):mechanisms of contractile depression by nitric oxide显示文摘 | Edwin K J Adam ES Dan L | 1998 | Mol Cell Cardiaol1998，30，： | 1 |
| 16 | 多样性的群体空间设计——纽约韦登迪+肯尼迪办公室显示文摘设计理念
WORKac在设计韦登迪+肯尼迪公司的纽约办公室时,把都市人口的密度作为首要参考因素,即最大限度地压缩个人的工作空间,而将设计重点转向扩充多样性的群体空间。由于在韦登迪+肯尼迪公司工作需要高度协作,所以WORKac设计的会议空间尽可能宽广,以容纳各种规模的会议和聚会。 | Amale Andraos Dan Wood Sam Dufaux Bruce Damonte Raymond Adams | 2014 | 设计家2014，，4： | 0 |
| 17 | 时尚成衣店显示文摘“时装的消费者是为设计买单而不是为材料。“设计师GuyZucker说。决定消费者购买欲的是时装是否流行和符含季节变化,而非质量。因此.对于时装设计师来说.对设计的投入和经历远远超过对质量和材料的研究。然而.在建筑领域,情况恰好相反-设计的投资远远小于材料的投资。因此.Z-A设计事务所在Delicatessen时装店的设计中表达了与建筑设计相反的逻辑——设计师将时装设计中的元素可自由拼接组合的材料和不密封材料.引入空间的设计里.服装设计中被考虑的因素被应用到室内空间设计里。 | Dan Affleck Adam Hostetler Leo Mulvehill Assaf Pinchuk | 2012 | 中国建筑装饰装修2012，，1： | 0 |
| 18 | Anatomic Correlates of Mitral Systolic Anterior Motion in Transposition of the Great Arteries Following Atrial Switch Operation显示文摘Introduction:We sought to investigate whether the development of sub-pulmonic systolic anterior motion(SAM)may be inherent to the anatomy of the the mitral valve(MV)or affected by external factors,such as a dilated right ventricle or chest abnormalities in d-looped transposition of the great arteries post atrial switch operation(d-TGA/AtS).Methods:Analysis was performed of clinical and cardiac imaging studies acquired on 19 adult patients with d-TGA/AtS(age 42±6 years old,56%male)between 2015–2019.Echocardiography data included mitral apparatus anatomy,and CT/MRI data included biventricular dimensions,function,and Haller index(HI)for pectus deformity.Results:Patients with leaflet SAM(n=6)compared to patients without SAM(n=13)had higher MV protrusion height(2.3±0.5 vs.1.5±0.4 cm,p≤0.01)and longer anterior MV leaflet length(3.1±0.4 cm vs.2.6±0.3 cm p≤0.05),when compared to those without.CT/MRI showed higher sub-pulmonic left ventricular ejection fraction(LVEF)in the SAM group(71%±8%vs.54%±7%,respectively).RV size and function,significant chest deformity(HI>3.5),presence of a ventricular lead pacemaker,and septal thickness did not play a role in development of SAM.Conclusions:An elongated mitral apparatus is associated with the development of SAM,and the development of left ventricular outflow tract obstruction(LVOTO),in d-TGA/AtS.LV hyperkinesia is associated with SAM.Systemic RV dimensions,septal thickness,and degree of chest deformity did not differ significantly between subjects with SAM and those without. | Norman Aiad Mark V.Sherrid Adam J.Small Youssef Elnabawi Jodi Feinberg Leon Axel Ralph Mosca T.K.Susheel Kumar Michael Argilla Dan G.Halpern | 2023 | Congenital Heart Disease2023，18，3： | 0 |
| 19 | SOA须应时而动——IBM专家解析中间件之道显示文摘随着中间件概念的不断更新,SOA已成为了一项事实标准。抱着这种观念,IBM高级管理人员和很多其他供应商、分析师和软件开发人员都开始重新定义SOA,并总结出了一些非常鲜明的观点。专家认为:SOA促进了服务流程的可用性,并将业务需求与IT功能真正意义上结合起来。如何部署SOA,选用SOA应遵循何种原因与何种时机,如何当前竞争激烈且快速变化的业务环境中具备快速的应变能力。一些专家分别根据他们与IBM内外开发先驱合作的实践经验提供了一些新颖的看法。而这些看法将帮助关注中间件发展的人们了解SOA在何时何地(甚至何种情况下)在新一代IT体系结构和开发计划中使用。 | Holt Adams Ali Arsanjani Sanjay Bose David K.Jackson ChristinaLau Calvin Lawrence Dan Wolfson Grady Booch Andras Szakal | 2006 | 软件世界2006，，8： | 0 |
| 20 | Emotions,Perceptions and Health Behaviors of Adult Congenital Heart Disease Patients during COVID-19 in New York City显示文摘Background:Adults with congenital heart disease(ACHD)have increased prevalence of mood and anxiety disorders.There are limited data regarding the influence of the COVID-19 pandemic on the mental health and health behaviors of these patients.Objective:The purpose is to evaluate the perceptions,emotions,and health behaviors of ACHD patients during the COVID-19 pandemic.Methods:In this cross-sectional study of ACHD patients,we administered surveys evaluating self-reported emotions,perceptions and health behaviors.Logistic regressions were performed to determine the adjusted odds of displaying each perception,emotion and health behavior based on predictor variables.Results:Ninety-seven patients(mean age 38.3 years,46.4%female,85.6%moderate or complex lesion)completed the survey.The majority of patients reported feeling moderately or very sad(63.1%),and 48.4%of patients identified themselves as feeling moderately or very anxious.The majority of patients perceived their risk of COVID-19 as moderate or high.Females were more likely to report feeling sad and anxious(95%CI 1.06–10.96,p-value 0.039,and 95%CI 1.44–15.30,p-value=0.012,respectively),and were associated with higher odds of having a perceived increased risk of COVID-19(95%CI 1.33–10.59,p-value 0.012).There was no association between ACHD anatomic or physiologic classification and perceptions,emotions and health behaviors.Conclusions:Females were more likely to report feeling sad,anxious and an increased risk of COVID-19 in comparison to males.These findings indicate the need for mental health support and promotion of health behaviors during the pandemic amongst all ACHD patients,regardless of underlying condition. | Jodi L.Feinberg Peter Sheng Stephanie Pena Adam J.Small Susanna Wendelboe Katlyn Nemani Vikram Agrawal Dan G.Halpern | 2022 | Congenital Heart Disease2022，17，5： | 0 |
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