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| 1 | Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal crohn's disease显示文摘AIM To examine the relationship between elevated granulocyte-macrophage colony-stimulating factor(GMCSF) auto-antibodies(Ab) level and time to surgical recurrence after initial surgery for Crohn's disease(CD). METHODS We reviewed 412 charts from a clinical database at tertiary academic hospital. Patients included in the study had ileal or ileocolonic CD and surgical resection of small bowel or ileocecal region for management of disease. Serum samples were analyzed for serological assays including GM-CSF cytokine, GM-CSF Ab, ASCA Ig G and Ig A, and genetic markers including SNPs rs2066843, rs2066844, rs2066845, rs2076756 and rs2066847 in NOD2, rs2241880 in ATG16 L1, and rs13361189 in IRGM. Cox proportional-hazards models were used to assess the predictors of surgical recurrence.RESULTS Ninety six percent of patients underwent initial ileocecal resection(ICR) or ileal resection(IR) and subsequently 40% of patients required a second ICR/IR for CD. GMCSF Ab level was elevated at a median of 3.81 mcg/mL. Factors predicting faster time to a second surgery included elevated GM-CSF Ab [hazard ratio(HR) 3.52, 95%CI: 1.45-8.53, P = 0.005] and elevated GM-CSF cytokine(HR = 2.48, 95%CI: 1.31-4.70, P = 0.005). Factors predicting longer duration between first and second surgery included use of Immunomodulators(HR = 0.49, 95%CI: 0.31-0.77, P = 0.002), the interaction effect of low GM-CSF Ab levels and smoking(HR = 0.60, 95%CI: 0.45-0.81, P = 0.001) and the interaction effect of low GM-CSF cytokine levels and ATG16 L1(HR = 0.65, 95%CI: 0.49-0.88, P = 0.006).CONCLUSION GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive CD behavior. | Grace Gathungu Yuanhao Zhang Xinyu Tian Erin Bonkowski Leahana Rowehl Julia Krumsiek Billy Nix Claudia Chalk Bruce Trapnell Wei Zhu Rodney Newberry Lee Denson Ellen Li | 2018 | World Journal of Gastroenterology2018，24，5： | 5 |
| 2 | Nuclear Ground-State Masses and Deformations显示文摘 | P. Moller J.R. Nix W.D. Myers W.J. Swiatecki | 1995 | Atomic Data and Nuclear Data Tables1995，，2： | 2 |
| 3 | Mechanism-based strain gradient plasticity— I. Theory显示文摘 | H. Gao Y. Huang W.D. Nix J.W. Hutchinson | 1999 | Journal of the Mechanics and Physics of Solids1999，，6： | 2 |
| 4 | Fast Track Program in Patients Undergoing Radical Cystectomy: Results in 362 Consecutive Patients显示文摘 | Raj S. Pruthi Matthew Nielsen Angela Smith Jeff Nix Heather Schultz Eric M. Wallen | 2010 | Journal of the American College of Surgeons2010，，1： | 2 |
| 5 | Robotic-assisted laparoscopic intracorporeal urinary diversion显示文摘 | Pruthi RS Nix J McRackan D | 2010 | European Urology2010，，06： | 2 |
| 6 | Formulat ion and efficacy of liposome encap sulated ant ibiotlcs for therapy of int racellular mycobacterium avium infection 显示文摘 | OH YK NIX DE ST RAUBINGER RM | 1995 | Antimicrob Agents Chemother1995，39，9： | 1 |
| 7 | Oatecne of the carvent management of sptenie injuries显示文摘 | Nix JA Cestanza M Daley BJ | 2001 | J Trauma2001，50，1： | 1 |
| 8 | Thyroid cancer reviewl: presentation and investigation of thyroid cancer 显示文摘 | Nix P Nieolaides A Coatesworth AP | 2005 | lnt J Clin Pract2005，59，： | 1 |
| 9 | Assessing the representativeness of the wet tropics of Queensland World heritage property显示文摘 | Mackey B G Nix H A Stein J A | 1989 | Biological Conservation1989，50，： | 1 |
| 10 | Is anticoagulation indicated for asymptomatic postoperative calf vein thrombosis? 显示文摘 | SOLIS MM RANVAL TJ NIX ML | 1992 | J Vase Surg1992，16，3： | 1 |
| 11 | Indentation size effects in crystalline materials: a law for strain gradient plasticity 显示文摘 | NIX W D GAO Huajian | 1998 | Journal of the Mechanics and Physics of Solids1998，46，3： | 1 |
| 12 | Indentation size effects in crystalline materials: a law for strain gradient plasticity显示文摘 | Nix W D Gao H J | 1998 | J Mech Phys Solids1998，46，3： | 1 |
| 13 | Vibrationbased structural damage identification显示文摘 | Farrar C R Doebling S W and Nix D A | 2001 | Philosophical Transactions of the Royal Society A:Physical Mathematical and Engineering Sciences2001，359，： | 1 |
| 14 | Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular显示文摘 | Oh YK Nix DE Straubinger RM | 1995 | Antimicro Agents Chemother1995，39，9： | 1 |
| 15 | Cognitive behaviors therapy of acute stress disorder: a four-year follow up 显示文摘 | Bryant RA Moulds ML Nix on RVD | 2003 | Behaviors Research and Therapy2003，41，4： | 1 |
| 16 | Size Dependence of Mechan- ical Properties of Gold at the Micron Scale in the Absence of Strain Gradients显示文摘 | Greer J R Oliver W C Nix W D | 2005 | Acta Materialia2005，53，6： | 1 |
| 17 | Strategies for assessing and managing organizational stakeholders显示文摘 | Savage G T Nix T W Whitehead C J | 1991 | The Executive1991，5，2： | 1 |
| 18 | Prospective randomized controlled trial of robotic versus open radical cystectomy for bladder cancer: perioperative and pathologic results显示文摘 | Nix J Smith A Kurpad R | 2010 | Eur Urol2010，57，2： | 1 |
| 19 | Indenter tip radius effect on the Nix-Gao relation in micro and nanoindentation hardness experiments显示文摘 | Qu S Huang Y Nix W D | 2004 | J Mater Res2004，19，11： | 1 |
| 20 | Phar-macodynamic interactions of antibiotics alone and in combination显示文摘 | Schentag JJ Strenkoski-Nix LC Nix DE | 1998 | Clin Infect Dis1998，27，1： | 1 |
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