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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Di- and triorganotin derivatives of 3S, 4S-3 -4--2-azetidinone: Synthesis, characterization and in vitro antitumour activity显示文摘 | GIELEN M DALIL H BIESEMANS M | 1999 | Appl Organomet Chem1999，13，： | 1 |
| 3 | Coke promoters improve acrolein selectivity in the gas-phase dehydration of glycerol to acrolein显示文摘 | Dalil M Edake M Sudeau C | 2016 | Appl Catal A2016，522，： | 1 |
| 4 | Dibutyltin perfluoroalkane-carboxylates:synthesis,NMR characterization and in vitro antitumour activity显示文摘 | KEMMER M DALIL H BIESEMANS M | 2000 | J Organomet Chem2000，608，： | 1 |
| 5 | Low polydispersity novolak resins for i-line resists显示文摘 | Wanat S Dalil Rahman M et al | 1999 | SPIE Proceedings1999，，3678： | 1 |
| 6 | Effect of structural differences in speed enhancers on positive photoresist composition显示文摘 | Cook M M Dalil Rahman M Lu P H | 1998 | SPIE Proceedings1998，，3333： | 1 |
| 7 | Meta-analysis of the p53 mutation database for mutant p53 biological activity reveals a methodologic bias in mutation detection显示文摘 | Thierry S Bernard A Dalil H | | 0，，： | 1 |
| 8 | Dibutyltin perfluoroalkanecarboxylates:synthesis,NMR characterization and in vitro antitumour activity显示文摘 | KEMMER M DALIL H BIESEMANS M | 2000 | J Organomet Chem2000，608，： | 1 |
| 9 | On finding most uniform spanning trees显示文摘 | DALIL Z SCHIEBER B | 1988 | Discrete Applied Mathematics1988，20，2： | 1 |
| 10 | On finding most uniform spanning trees显示文摘 | Dalil Z Schieber B | 1988 | Discrete Applied Mathematics1988，20，2： | 1 |
| 11 | Harnessing γδ T cells in anticancer immunotherapy显示文摘 | Dalil Hannani Yuting Ma Takahiro Yamazaki Julie Déchanet-Merville Guido Kroemer Laurence Zitvogel | 2012 | Trends in Immunology2012，，5： | 1 |
| 12 | Meta analysis of the p53 mutation database for mutant p53 biological activity reveals a methodologic bias in mutation detection显示文摘 | Thierry S Bernard A Dalil H | 2006 | Clin Cancer Res2006，12，1： | 1 |
| 13 | Isolation of novolak resin at low temperature显示文摘 | Dalil R M Aubin D P Khanna D N | 1996 | SPIE Proceedings1996，，2724： | 1 |
| 14 | Synthesis of novolak resin by acid removal after condensation(ARAC) process显示文摘 | Cook M M Dalil R M Khanna D N | 1997 | SPIE Proceedings1997，，3049： | 1 |
| 15 | On finding most uniform spanning trees显示文摘 | Dalil Z Schieber B | 1988 | Discrete Applied Mathematics1988，20，2： | 1 |
| 16 | Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells显示文摘 | Yuting Ma Sandy Adjemian Stephen R. Mattarollo Takahiro Yamazaki Laetitia Aymeric Heng Yang Jo?o Paulo Portela Catani Dalil Hannani Helene Duret Kim Steegh Isabelle Martins Frederic Schlemmer Micka?l Michaud Oliver Kepp Abdul Qader Sukkurwala Laurie Menge | 2013 | Immunity2013，，4： | 1 |
| 17 | Evaluation of antifungal activity of free fatty acids methyl esters fraction isolated from Algerian Linum usitatissimum L.seeds against toxigenic Aspergillus显示文摘Objective:The aim of this study was to evaluate the anlilungal activity of the major fraction of fatty acids methyl esters(FAMEs)isolated from Linum usitatissimum L.seeds oil collected from Bechar department(Algeria).Methods:The assessment ol antifungal activity was carried out in terms of percentage of radial growth on solid medium potatoes dextrose agar PDA)and biomass growth inhibition on liquid medium(potatoes dextrose broth PDB)against two fungi.Results:The FAMEs was found to be effective in inhibiting the radial mycelial growth of Aspergillus fluctis more than Aspergillus ochraceus on all tested concentrations.The highest antifungal index was found to be(54.19%]compared to Aspergillus ochraeeus(40.48%).The results of the antifungal activity of the FAMEs inhibition of bioniass on liquid medium gave no discounted results,but this does not exclude the antifungal activity.Conclusions:We can assume that the observed antifungal potency may be due to the abundance of linoleic andα-linolenic acids in linseed oil which appears to be promising to treat fungal infections,storage fungi and food spoilage in food industry field. | Amrouche Abdelillah Benmehdi Houcine Dalile Halima Chabane sari Meriem Zaaboub Imane Smahi Djamal Eddine Moussaoui Abdallah Chabane sari Daoudi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，6： | 0 |
| 18 | Acute kidney injury following autoimmune hemolytic anemia due to simultaneous use of ciprofloxacin and hydrochlorothiazide:A case report and review of the literature显示文摘Introduction:Rare cases of autoimmune hemolytic anemia(AHA)associated with using ciprofloxacin or hydrochlorothiazide(HCTZ)alone have been reported before.However,simultaneous use of both drugs could lead to a severe clinical condition.This study presents the combination of acute kidney injury(AKI)and AHA following the simultaneous use of ciprofloxacin and HCTZ for three days.Case Description:A 42-year-old Iranian woman presented to the emergency department with symptoms of fatigue,lethargy,nausea and vomiting,ataxia,oliguria,dark urine,and jaundice.The patient reported using HCTZ due to high blood pressure and ciprofloxacin for a urinary tract infection three days before presentation.Early laboratory findings revealed hemolytic anemia with a hemoglobin of 7 g/dl,the strongly positive direct and indirect Coombs test,high level of lactate dehydrogenase(820 IU/L),and hyperbilirubinemia(total:3 mg/dL and direct:1.2 mg/dL).Furthermore,hyperkalemia(5.2 mEq/L),hyperphosphatemia(6.2 mg/dL),high levels of BUN(100 mg/dL),and creatinine rise(6.8 mg/dL)were found.Urine analysis showed 2+blood,4-6 red blood cells,and cola-colored urine.Based on the findings,druginduced AHA,followed by AKI,was diagnosed.Following,the drugs were stopped and steroid therapy was initiated.The patient underwent four sessions of hemodialysis to improve the AKI.Conclusion:Healthcare providers should be aware of the life-threatening adverse effects of commonly used drugs such as ciprofloxacin or HCTZ.The timely diagnosis of the offending drugs leads to avoiding the persistence of the risk factor and the deterioration of the patient's clinical condition. | Fatemeh Yaghoubi Farnaz Tavakoli Davood Dalil Hoda Jamaloo | 2023 | Rheumatology & Autoimmunity2023，3，1： | 0 |
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