维普期刊资源整合服务平台（V6.5）

191篇 您的检索式：作者名="Kepp"

选中清除导出查看参考文献查看引证文献引用追踪共10页首页上一页第1页下一页末页 /10 跳转

	题名	作者	年代	出处	被引量
1	MLKL regulates necrotic plasma membrane permeabilization显示文摘	Lorenzo Galluzzi	2014	Cell Research2014，24，2：	12
2	Immunogenic Cell Death in Cancer Therapy显示文摘	Guido Kroemer Lorenzo Galluzzi Oliver Kepp Laurence Zitvogel	2013	Annual Review of Immunology2013，，：	2
3	FADD: an endogenous inhibitor of RIP3-driven regulated necrosis显示文摘	Lorenzo Galluzzi Oliver Kepp Guido Kroemei	2011	Cell Research2011，21，10：	2
4	AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer.	Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger	2019	Cell Research2019，29，7：	2
5	Molecular characteristics of immunogenic cancer cell death显示文摘	Tesniere A Panaretakis T Kepp O	2008	Cell Death Differ2008，15，1：	1
6	Immunogenic death of colon cancer cells treated with oxaliplatin显示文摘	Tesniere A Schlemmer F Boige V Kepp O Martins I Ghiringhelli F	2010	Oncogene2010，29，：	1
7	Enhanced stabilization of sewage sludge through thermal hydrolysis-three years of experience with full scale plant 显示文摘	Kepp U Machenbach L Weisz N	2000	Water Science and Technology2000，42，9：	1
8	Caspase-3 and prostaglandinssignal for tumor regrowth in cancer therapy显示文摘	Galluzzi L Kepp O Kroemer G	2012	Oncogene2012，31，23：	1
9	Mitochondrial liaisons of p53显示文摘	Galluzzi L Morselli E Kepp O		0，，06：	1
10	Bioinorganic chemistry of Alzheimer's disease显示文摘	Kepp KP	2012	Chem Rev2012，112，10：	1
11	Inflammasomes in carcinogenesis and anticancer immune responses 显示文摘	Zitvogel L Kepp O Galluzzi L	2012	Nat Immunol2012，13，4：	1
12	Mechanisms of pre-apoptotic ealreticulin exposure in immunogenic cell death显示文摘	Panaretakis T Kepp O Brockmeier U	2009	EMBO J2009，28，5：	1
13	Targeting post- mitochondrial effectors of apoptosis for neuroprotection 显示文摘	Gal\|uzzi L Morselli E Kepp O	2009	Biochim Biophys Acta2009，1787，5：	1
14	Disruption of the PP1/GADD34 complex induces calreticulin exposure 显示文摘	Kepp O Galluzzi L Giordanetto F	2009	Cell Cycle2009，8，23：	1
15	Anti-and pro-tumor functions of autophagy显示文摘	Eugenia Morselli Lorenzo Galluzzi Oliver Kepp	2009	Biochim Biophys Acta2009，10，：	1
16	Immune parameters affecting the efficacy of chemotherapeutic regimens显示文摘	Zitvogel L Kepp O Kroemer G	2011	Nat Rev Clin Oncol2011，8，3：	1
17	Mechanisms of pre- apoptotic calreticulin exposure in immunogenic cell death 显示文摘	Panaretakis T Kepp O Bmckmeier U	2009	EMBO J2009，28，5：	1
18	Anti- and pro-tumor functions of autophagy显示文摘	Morselli E Galluzzi L Kepp O	2009	Biochim Biophys Acta2009，1793，9：	1
19	Adenine nucleotide translocase: a component of the phylogen- etically conserved cell death machinery显示文摘	Zhivotovsky B Galluzzi L Kepp O	2009	Cell Death Differ2009，16，11：	1
20	Inflammasomes in carcinogenesis and anticancer immune responses显示文摘	Zitvogel L Kepp O Galluzzi L	2012	Nat Immunol2012，13，4：	1

返回顶部每页显示：

共10页首页上一页第1页下一页末页 /10 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示