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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Impact of LDL carotenoid and α-tocopherol content on LDL oxidation by endothelial cells in culture显示文摘 | Dugas T R Morel D W Harrison E H | 1998 | J Lipid Res1998，39，5： | 1 |
| 3 | Dietary supplementation with β-carotene, but not with lycopene,inhibits endothelial cell-mediated oxidation of low-density lipoprotein显示文摘 | Dugas T R Morel D W Harrison E H | 1999 | Free Radic Biol Med1999，26，910： | 1 |
| 4 | Carbon dioxide fluxes over bermudagrass, native prairie and sorghum显示文摘 | Dugas W A Heuer M L Mayeux H S | 1999 | A gricultural and Forest Meteorology1999，93，： | 1 |
| 5 | Tillage-induced soil carbon dioxide loss from different cropping systems 显示文摘 | Reicosky DC Dugas W A Torbert H A | 1997 | Soil and Tillage Research1997，41，： | 1 |
| 6 | Tillage-induced soil carbon dioxide loss from different cropping systems 显示文摘 | Reicosky D C Dugas W A Torbert H A | 1997 | Soil and Tillage Research1997，41，： | 1 |
| 7 | Carbon dioxide capture with concentrated, aqueous piperazine显示文摘 | Freeman S A Dugas R Wagener D H V | 2010 | International JournalofGreenhouse Gas Control2010，4，2： | 1 |
| 8 | Tillage-induced soil carbon dioxide loss from different cropping systems显示文摘 | Reicosky D C Dugas W A Torbert H A | 1997 | Soil and Tillage Research1997，41，12： | 1 |
| 9 | Intolerance of uncertainty and problem orientation in worry显示文摘 | Michel J Dugas Mark H Freeston Robert Ladouceur | 1997 | Cognitive Therapy and Research1997，21，6： | 1 |
| 10 | Race and the insulin re-sistance syndrome显示文摘 | KRAMER H DUGAS L ROSAS SE | 2013 | Semin Nephrol2013，33，5： | 1 |
| 11 | Rate-based process modeling study of CO2 capture withaqueous monoethanolamine solution显示文摘 | ZHANG Y CHEN H CHEN C C PLAZA J M DUGAS R ROCHELLE G T | 2009 | Ind Eng Chem Res2009，48，20： | 1 |
| 12 | Tillage-inducedsoil carbon dioxide loss from different cropping systems 显示文摘 | Reicosky D G Dugas W A Torbert H A | 1997 | Soil and Tillage Research1997，41，： | 1 |
| 13 | Carbon dioxide fluxes over Bermuda grass,native prairie and sorghum显示文摘 | Dugas W A Heuer M L Mayeux H S | 1999 | Agricultural and Forest Meteorology1999，93，2： | 1 |
| 14 | Rate-based process modeling study of CO2 capture with aqueous monoethanolamine solution显示文摘 | ZHANG Y CHEN H CHEN C PLAZA J M DUGAS R ROCHELLE G T | 2009 | Ind Eng Chem Res2009，48，20： | 1 |
| 15 | The Alu- minum-Strontium Phase Diagram显示文摘 | CLOSSET B DUGAS H PEKGULERYUZ M | 1986 | METALLURGICAL TRANSACTION S A1986，，17： | 1 |
| 16 | Biooranic Chemistry Fomtiers显示文摘 | | 1991 | Berlin HeidelHerg:Springer-Verlarg1991，，2： | 1 |
| 17 | Dietary supplementation with β-carotene, but not with lycopene inhibits endothelial cell-mediated oxidation of low-density lipoprotein显示文摘 | Dugas T R Moml D W Harrison E H | 1999 | Free Radio Biol Med1999，26，： | 1 |
| 18 | Carbon dioxide fluxes over Bermudagrass, native prairie and sorghum 显示文摘 | Dugas W A Heuer M L Myeux H S | 1999 | Agricultural and Forest Meteorology1999，93，21： | 1 |
| 19 | Direct and indirect effects of elevated CO2 on transpiration from Quercusmyrtifolia in a scrub-oak ecosystem显示文摘 | Dugas W A Hymus G J | 2003 | International Journal of Dairy Technology2003，，9： | 1 |
| 20 | International lournal of Fraeture显示文摘 | Duga J J Fisher W H Baxbdum R W | 1998 | 94:33-491998，94，： | 1 |
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