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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A review of the environmental fate, effects and exposures of Bisphenol A 显示文摘 | Staples C A Dom P B Klecka G M | 1998 | Chemosphere1998，36，10： | 1 |
| 3 | Host cell-catalyzed Spalmitoylation mediates Golgi targeting of the legionella ubiquitin ligase Gob X显示文摘 | LIN Y H DOMS A G CHENG E | 2015 | J Biol Chem2015，290，25： | 1 |
| 4 | 2007 ESH-ESC Guidelines for the management of arterial hypertension:the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Mansia G De Backer G Dom In Iczak A | | 0，，： | 1 |
| 5 | Automated solid-phaseextraction for sample preparation followed by high-performance liquid chro-matography with diode array and mass spectrometric detection for the anal-ysis of resveratrol derivatives in wine显示文摘 | DOMNGUEZ C GUILLN D A BARROSO C G | 2001 | Journal of Chromatography A2001，918，： | 1 |
| 6 | Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes显示文摘 | RUIZ-HURTADO G DOMNGUEZ-RODRGUEZ A PEREIRA L | 2012 | J Mol Cell Cardiol2012，53，： | 1 |
| 7 | Epac in cardiac calcium signaling显示文摘 | RUIZ-HURTADO G MOREL E DOMNGUEZRODRGUEZ A | 2013 | Journal of Molecular and Cellular Cardiology2013，58，： | 1 |
| 8 | Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes显示文摘 | RUIZ-HURTADO G DOMNGUEZ-RODRGUEZ A PEREIRA L | 2012 | J Mol Cell Cardiol2012，53，： | 1 |
| 9 | Pathogenicity islands and virulence evolution in Listeria 显示文摘 | Va'zquez-Boland J A G Dom'nguez-Bernal B Gonza'lez-Zorn | 2001 | Microb Infect2001，3，： | 1 |
| 10 | Diversity of receptors binding HIV on dendritic cell subsets显示文摘 | Turville SG Cameron PU Handley A Lin G Pohlmann S Doms RW Cunningham AL | 2002 | Nat Immunol2002，3，10： | 1 |
| 11 | A review of the environmental fate,effects,and exposures of bisphenol A显示文摘 | Staples C A Dom P B Klecka G M | 1998 | Chemosphere1998，36，10： | 1 |
| 12 | IL-1beta,TNF-alpha,total antioxidative status and microbiological findings in chronic periodontitis treated with fluorescencecontrolled Er:YAG laser radiation显示文摘 | Domínguez A Gómez C García-Kass AI | 2010 | Lasers Surg Med2010，42，1： | 1 |
| 13 | Cancer‐associated fibroblast and M 2 macrophage markers together predict outcome in colorectal cancer patients显示文摘 | Mercedes Herrera Alberto Herrera Gemma Domínguez Javier Silva Vanesa García José M. García Irene Gómez Beatriz Soldevilla Concepción Mu?oz Mariano Provencio Yolanda Campos‐Martin Antonio García de Herreros Ignacio Casal Félix Bonilla Cristina Pe?a | 2013 | Cancer Sci2013，，4： | 1 |
| 14 | Loss of E-cad- herin expression in melanoma ceils involves up-regulation of the transcriptional repressor Snail显示文摘 | Poser I Dom i nguez D de Herreros A G | 2001 | J Biol Chem2001，276，24： | 1 |
| 15 | The Spanish Pancreatic Club recommendations for the diagnosis and treatment of chronic pancreatitis: Part 1 (diagnosis)显示文摘 | J. Martínez A. Abad-González J.R. Aparicio L. Aparisi J. Boadas E. Boix G. de las Heras E. Domínguez-Mu?oz A. Farré L. Fernández-Cruz L. Gómez J. Iglesias-García K. García-Malpartida L. Guarner J. Lari?o-Noia F. Lluís A. López X. Molero O. Moreno-Pérez S. | 2013 | Pancreatology2013，，1： | 1 |
| 16 | A review of the environmental fate,effects,and exposures of bisphenol A显示文摘 | Staples C A Dom P B Klecka G M | 1998 | Chemosphere1998，36，10： | 1 |
| 17 | Therapeutic targets in dry eye syndrome显示文摘 | Peral A Domínguez-Godínez CO Carracedo G | 2008 | Drug NewsPerspect2008，21，3： | 1 |
| 18 | 2007 guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Mancia G de Backer G Dom iniczak A | 2007 | Eur Heart J2007，28，14： | 1 |
| 19 | Insulin stimulates sodiumpotassium activated ATPase from rat hippocampus显示文摘 | Bernstein HG Poeggel G Dom A | 1981 | Experientia1981，37，4： | 1 |
| 20 | Flame ionization detection relative response factors of some polycyclic aromatic compounds: Determination of the main components of the coal tar pitch volatile fraction 显示文摘 | BLANCO C G CANGA J S DOM~NGUEZ A | 1992 | Journal of Chromatography1992，607，： | 1 |
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