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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | DuaISPHysics:A numerical tool to simulate real breakwaters显示文摘The open-source code DualSPHysics is used in this work to compute the wave run-up in an existing dike in the Chinese coast using realistic dimensions, bathymetry and wave conditions. The GPU computing power of the DualSPHysics allows simulating real-engineering problems that involve complex geometries with a high resolution in a reasonable computational time. The code is first validated by comparing the numerical free-surface elevation, the wave orbital velocities and the time series of the run-up with physical data in a wave flume. Those experiments include a smooth dike and an armored dike with two layers of cubic blocks. After validation,the code is applied to a real case to obtain the wave run-up under different incident wave conditions. In order to simulate the real open sea, the spurious reflections from the wavemaker are removed by using an active wave absorption technique. | 张峰 Alejandro Crespo Corrado Altomare José Domínguez Andrea Marzeddu 商少平 Moncho Gómez-Gesteira | 2018 | Journal of Hydrodynamics2018，30，1： | 2 |
| 3 | Hydrothermal processing of lignccellulosic materials显示文摘 | GARROTE G DOM(I)NGUEZ H PARAJ(O) J | 1999 | Holzals Rohund Werkstoff1999，57，3： | 1 |
| 4 | Orbitalcavernoushemangioma : findings on sequential Gd-enhanced MRI 显示文摘 | Wilms G Raat H Dom R | 1995 | J Comput Assist Tomogr1995，19，： | 1 |
| 5 | Orbital cavernous hemangioma: find- ings on sequential Gd-enhanced MRI 显示文摘 | Wilms G Raat H Dom R | 1995 | J Comput Assist Tomogr1995，19，4： | 1 |
| 6 | Substance use disorders and the orbitofrontal cortex: systematic review of behavioural decision-making and neuroimaging studies 显示文摘 | Dom G Sabbe B HuIstijn W | 2005 | Br J Psychiatry2005，187，： | 1 |
| 7 | Hydrothermal processing of lignocellulosic materials显示文摘 | Garrote G Dom?? nguez H Parajo JC | 1999 | Holz als Roh- und Werk- stoff1999，57，3： | 1 |
| 8 | The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infection 显示文摘 | Vink C Van Dom J G | 1998 | J Virol1998，72，： | 1 |
| 9 | Critically I11 patients with 2009 influenza A(H1N1) in Mexico显示文摘 | Domínguez-Cherit G Lapinsky SE Macias AE | 2009 | JAMA2009，302，17： | 1 |
| 10 | Effect of different cooking methods on lipid oxidation and formation of volatile compounds in foal meat显示文摘 | Domínguez M Gómez M Fonseca S | 2014 | Meat Science2014，97，2： | 1 |
| 11 | A review of the environmental fate, effects and exposures of Bisphenol A 显示文摘 | Staples C A Dom P B Klecka G M | 1998 | Chemosphere1998，36，10： | 1 |
| 12 | Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extraeellular matrix proteins 显示文摘 | Vanier G Sekizaki T Dom nguez-Punaro M C | 2008 | Vet Microbiol2008，12，： | 1 |
| 13 | Xylooligosaccharides:properties and production technologies显示文摘 | Alonso J L Domínguez H Garrote G | 2003 | Electronic Journal of Evironmental Agricultural and Food Chemistry2003，2，1： | 1 |
| 14 | et al: Impulsivity in abstinent early-and late-onset alcoholics: differences in self- report measures and a discounting task显示文摘 | DOM G D HAENE P HULSTIJN W | 2006 | Addiction2006，101，1： | 1 |
| 15 | Differences in impulsivity and sensation seeking between early- and late-onset alcoholics 显示文摘 | Dom G Hulstijn W Sabbe B | 2006 | Addict Behav2006，31，2： | 1 |
| 16 | Decision-making deficits in alcohol-dependent patients with and without comorbid personality disorder显示文摘 | Dom G De Wilde B Hulstijn W | | 0，，： | 1 |
| 17 | Host cell-catalyzed Spalmitoylation mediates Golgi targeting of the legionella ubiquitin ligase Gob X显示文摘 | LIN Y H DOMS A G CHENG E | 2015 | J Biol Chem2015，290，25： | 1 |
| 18 | 2007 ESH-ESC Guidelines for the management of arterial hypertension:the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Mansia G De Backer G Dom In Iczak A | | 0，，： | 1 |
| 19 | Barriers Perceived by Teachers at Work, Coping Strategies, Self-efficacy and Burnout 显示文摘 | Betoret Femando Dom e nech Artiga Amparo G 6 mez | 2010 | The Spanish Journal of Psychology2010，13，2： | 1 |
| 20 | Critically ill patients with 2009 influenza A(H1N1)in Mexico显示文摘 | Domínguez-Cherit G Lapinsky SE Macias AE | 2009 | JAMA2009，302，17： | 1 |
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