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| 1 | Co-delivery of doxorubicin and quercetin via mPEG-PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity显示文摘橡黄素(Que ) 是自然多功能的 bioflavonoid,并且为减少不利副作用并且提高化学疗法的药的反肿瘤功效显示出大潜力。然而,它的临床的申请在生理的系统由于很低的溶解度和结构的不稳定性被限制。此处,我们共同交付由开发 amphiphilic 聚合物包括的 biocompatible nanocarrier 的恐水病的橡黄素和吸水的 doxorubicin (纪录影片) , methoxy poly (乙烯乙二醇) 并且 poly (D, L-lactide-co-glycolide ) 分别地。反肿瘤和这个系统的预防功效被评估在细胞并且动物模型。我们说明的调查结果 Dox-Que nanoparticulate 明确的表达保护了正常脉管的 endothelial 房间免受免费的任何一个或 nanoparticulate 的伤害导致 doxorubicin 的 cytotoxicity 和增加的癌症房间死亡。与免费 doxorubicin 和它的 nanoformulation 相比,用我们的 nanosystem 的橡黄素和 doxorubicin 的合作交货 synergistically 禁止了肿瘤生长,当在浆液维持心脏的功能指示物的正常层次并且在心织物恢复组织病理学说的损坏时。这研究为提高反癌症药功效并且减少 nanoparticulate 表明有希望的策略正常纸巾上的导致化疗的毒性。 | Waseem Akhtar Qureshi Ruifang Zhao Hai Wang Tianjiao Ji Yanping Ding Ayesha Ihsan Ayeesha Mujeeb Guangjun Nie Yuliang Zhao | 2016 | Science Bulletin2016，61，21： | 9 |
| 2 | Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling显示文摘Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury,but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes(CMs) for driving the differentiation of cardiac stem cells(CSCs).Forced hypoxia-inducible factor 1α(HIF-1α) expression and physical hypoxia(5% O_2) treatment could induce Jagged1 expression in neonatal rat CMs. Pharmacological inhibition of HIF-1α by YC-1 attenuated hypoxia-promoted Jagged1 expression in CMs. An ERK inhibitor(PD98059), but not inhibitors of JNK(SP600125), Notch(DAPT), NF-κB(PTDC), JAK(AG490), or STAT3(Stattic) suppressed hypoxiainduced Jagged1 protein expression in CMs. c-Kit^+ CSCs isolated from neonatal rat hearts using a magnetic-activated cell sorting method expressed GATA4, SM22α or vWF, but not Nkx2.5 and cTnI.Moreover, 87.3% of freshly isolated CSCs displayed Notch1 receptor expression. Direct co-culture of CMs with BrdU-labeled CSCs enhanced CSCs differentiation, as evidenced by an increased number of BrdU^+/Nkx2.5^+ cells, while intermittent hypoxia for 21 days promoted co-culture-triggered differentiation of CSCs into CM-like cells. Notably, YC-1 and DAPT attenuated hypoxia-induced differentiation.Our results suggest that hypoxia induces Jagged1 expression in CMs primarily through ERK signaling,and facilitates early cardiac lineage differentiation of CSCs in CM/CSC co-cultures via HIF-1α/Jagged1/Notch signaling. | Keke Wang Ranran Ding Yanping Ha Yanan Jia Xiaomin Liao Sisi Wang Rujia Li Zhihua Shen Hui Xiong Junli Guo Wei Jie | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 7 |
| 3 | On the viscosity of magnetic fluid with low and moderate solid fraction显示文摘The design of a pressurized capillary rheometer operating at prescribed temperature is described to measure the viscosity of magnetic fluids(MFs) containing Fe3O4 magnetic nanoparticles(MNPs).The equipment constant of the rheometer was obtained using liquids with predetermined viscosities.Experimentally measured viscosities were used to evaluate different equations for suspension viscosities.Deviation of measured suspension viscosities from the Einstein equation was found to be basically due to the influence of spatial distribution and aggregation of Fe3O4 MNPs.By taking account of the coating layer on MNPs and the aggregation of MNPs in MFs,a modified Einstein equation was proposed to fit the experimental data.Moreover,the influence of external magnetic field on viscosity was also taken into account.Viscosities thus predicted are in good agreement with experimental data.Temperature effect on suspension viscosity was shown experimentally to be due to the shear-thinning behavior of the MFs. | Zhiqiang Ren Yanping Han Ruoyu Hong Jianmin Ding Hongzhong Li | 2008 | Particuology2008，6，3： | 5 |
| 4 | Commutators of Littlewood-Paley operators显示文摘Let b ∈ Lloc(Rn) and L denote the Littlewood-Paley operators including the LittlewoodPaley g function,Lusin area integral and gλ* function. In this paper,the authors prove that the Lp boundedness of commutators [b,L] implies that b ∈ BMO(Rn) . The authors therefore get a characterization of the Lp-boundedness of the commutators [b,L]. Notice that the condition of kernel function of L is weaker than the Lipshitz condition and the Littlewood-Paley operators L is only sublinear,so the results obtained in the present paper are essential improvement and extension of Uchiyama's famous result. | CHEN YanPing DING Yong | 2009 | Science China Mathematics2009，52，11： | 4 |
| 5 | Nestedness of snake assemblages on islands of an inundated lake显示文摘 | Yanping WANG Xi WANG Ping DING | 2012 | Current Zoology2012，58，6： | 4 |
| 6 | High-performance polarization-sensitive photodetector based on a few-layered PdSe2 nanosheet显示文摘The extraordinary optical and electronic properties of anisotropic two-dimensional materials,such as black phosphorus,ReS2,and GeSe,enable them a promising component of polarization-sensitive photodetectors.However,these applications are significantly limited by the challenges of air-stability,response time,and linearly dichroic ratio.Interestingly,palladium diselenide(PdSe2)with high air stability is an emerging material that has robust in-plane anisotropy induced by its asymmetric pentagonal lattice structure.We have successfully prepared a few-layer PdSe2 using micromechanical exfoliation,and here we demonstrate the strong linear dichroism behavior of PdSe2 by polarization-resolved absorption spectra measurements.Such unique linear dichroism,endows the PdSe2 photodetector powerful ability to detect polarized light.The photodetector based on 5L PdSe2,as tested with polarization-dependent photocurrent mapping,exhibited competitive capability to detect polarized light,achieving a significant photocurrent on/off ratio(>10^2),the quite fast response time(<11 ms)and robust linearly dichroic ratios(/max//min≈1.9 at 532 nm).These results are essential advance in the development of polarization-sensitive photodetector,a crucial step towards opening up a new avenue for the application of 2D optoelectronic devices. | Jiahong Zhong Juan Yu Lingkai Cao Cheng Zeng Junnan Ding Chunxiao Cong Zongwen Liu Yanping Liu | 2020 | Nano Research2020，13，6： | 4 |
| 7 | Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis显示文摘The plant aluminum(Al)-activated malate transporter ALMT1 mediates the efflux of malate to chelate the Al in acidic soils and underlies the plant Al resistance.Here we present cryo-electron microscopy(cryo-EM)structures of Arabidopsis thaliana ALMT1(AtALMT1)in the apo,malate-bound,and Al-bound states at neutral and/or acidic pH at up to 3.0Åresolution.The AtALMT1 dimer assembles an anion channel and each subunit contains six transmembrane helices(TMs)and six cytosolicα-helices.Two pairs of Arg residues are located in the center of the channel pore and contribute to malate recognition.Al binds at the extracellular side of AtALMT1 and induces conformational changes of the TM1-2 loop and the TM5-6 loop,resulting in the opening of the extracellular gate.These structures,along with electrophysiological measurements,molecular dynamic simulations,and mutagenesis study in Arabidopsis,elucidate the structural basis for Al-activated malate transport by ALMT1. | Jiangqin Wang Xiafei Yu Zhong Jie Ding Xiaokang Zhang Yanping Luo Ximing Xu Yuan Xie Xiaoxiao Li Tian Yuan Shao Jian Zheng Wei Yang Jiangtao Guo | 2022 | Cell Research2022，32，1： | 3 |
| 8 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 9 | Self-assembled transparent conductive composite films of carboxylated multi-walled carbon nanotubes/poly(vinyl alcohol) electrospun nanofiber mats显示文摘 | Zhaoqiang Ding Yanping Zhu Christopher Branford-White Kan Sun Syeda Um-i-Zahra Jing Quan Huali Nie Limin Zhu | 2014 | Materials Letters2014，，： | 1 |
| 10 | L p Bounds for the Commutator of Parabolic Singular Integral with Rough Kernels显示文摘 | Yanping Chen Yong Ding | 2007 | Potential Analysis2007，，4： | 1 |
| 11 | Effect of solid-solution treatments on the microstructure and mechanical properties of AM60B+xRE and AZ91D+xRE magnesium alloy(固溶处理对AM60B+xRE及AZ91D+xRE镁合金性能的影响)显示文摘 | PENG Liming(彭立明),ZENG Xiaoqin(曾小勤),ZHU Yanping(朱燕萍),DING Wenjiang(丁文江) | 2003 | Chinese Journal of Materials Research(材料研究学报)2003，，1： | 1 |
| 12 | Effects of rare earths on the microstructure, properties and fracture behavior of Mg-Al alloys 显示文摘 | Lu Yizhen Wang Qudong Zeng Xiaoqin Ding Wenjiang Zhai Chunquan Zhu Yanping | 2000 | Materials Science and Engineering A2000，278，： | 1 |
| 13 | Spintronics in Two-Dimensional Materials显示文摘Spintronics,exploiting the spin degree of electrons as the information vector,is an attractive field for implementing the beyond Complemetary metal-oxide-semiconductor(CMOS)devices.Recently,two-dimensional(2D)materials have been drawing tremendous attention in spintronics owing to their distinctive spin-dependent properties,such as the ultralong spin relaxation time of graphene and the spin-valley locking of transition metal dichalcogenides.Moreover,the related heterostructures provide an unprecedented probability of combining the di erent characteristics via proximity e ect,which could remedy the limitation of individual 2D materials.Hence,the proximity engineering has been growing extremely fast and has made significant achievements in the spin injection and manipulation.Nevertheless,there are still challenges toward practical application;for example,the mechanism of spin relaxation in 2D materials is unclear,and the high-effciency spin gating is not yet achieved.In this review,we focus on 2D materials and related heterostructures to systematically summarize the progress of the spin injection,transport,manipulation,and application for information storage and processing.We also highlight the current challenges and future perspectives on the studies of spintronic devices based on 2D materials. | Yanping Liu Cheng Zeng Jiahong Zhong Junnan Ding Zhiming MWang Zongwen Liu | 2020 | Nano-Micro Letters2020，12，7： | 1 |
| 14 | Coupling mechanism of mathematical models for sediment transport based on characteristic theory显示文摘This paper aims to explore the coupling mechanism between flow movement, sediment transport and riverbed evolution in currently widely used mathematical models for sediment transport. Based on characteristic theory, analytic forms of eigenvalues,eigenvectors and characteristic relationships of total-sediment transport model, bed-load transport model and suspenedload transport model were derived, respectively. The singular perturbation technology was implemented to obtain the asymptotic solutions to different families of eigenvalues. The results indicate that, interactions between motion variables were explicitly coupled in the characteristics of total-sediment transport model and bed-load transport model. Further qualitative and quantitative analysis demonstrates that high sediment transport intensity and significant riverbed change will inevitably affect the property of flow movement. In the process of deposition, sediment-laden flow will move faster when sediment transport intensity becomes stronger. In contrast, the wave of flow will propagate at slower speed as erosion intensity becomes stronger.For most existing suspended-load transport models, however, the characteristics are decoupled as the interactions between motion variables cannot be integrally illustrated in eigenvalues, eigenvectors and characteristic relationship. | DING Yun LI ZuiSen ZHONG DeYu KANG YanPing | 2016 | Science China(Technological Sciences)2016，59，11： | 1 |
| 15 | The small-island effect in amphibian assemblages on subtropical land-bridge islands of an inundated lake显示文摘 | Yanping WANG Xi WANG Qiang Wu Cangsong CHEN Aichun Xu Ping DING | 2018 | Current Zoology2018，64，3： | 1 |
| 16 | A 21--GHz 8-modulus prescaler and a 20--GHz phase-locked loop fabricated in 130--nm CMOS 显示文摘 | Yanping Ding Kenneth K O | 2007 | IEEE J So[ Sta Circ2007，42，6： | 1 |
| 17 | Effect of cerium on microstructures and mechanical properties of AZ61 wrought magnesium alloy显示文摘 | Haitao Zhou Xiaoqin Zeng Liufa Liu Ya Zhang Yanping Zhu Wenjiang Ding | 2004 | Journal of Materials Science2004，，23： | 1 |
| 18 | Tensile properties of extruded ZK60–RE alloys显示文摘 | Chunjiang Ma Manping Liu Guohua Wu Wenjiang Ding Yanping Zhu | 2002 | Materials Science & Engineering A2002，，1： | 1 |
| 19 | The boundedness for commutators of maximal hypersingular integrals with rough kernels显示文摘In this paper,we prove that the commutators of maximal hypersingular integrals with rough kernels are bounded from the Sobolev space Lpγ(Rn) to the Lebesgue space Lp(Rn),which is a substantial improvement and an extension of some known results. | CHEN YanPing DING Yong LI Ran | 2013 | Science China Mathematics2013，56，4： | 1 |
| 20 | Influence of superior cervical ganglionectomy on hippocampal neurogenesis and learning and memory in adult rats显示文摘BACKGROUND:Studies have shown that neurogenesis in the dentate gyrus plays an important role in learning and memory.However,studies have not determined whether the superior cervical ganglion or the sympathetic nerve system influences hippocampal neurogenesis or learning and memory in adult rats. OBJECTIVE:To observe differences in dentate gyrus neurogenesis,as well as learning and memory,in adult rats following superior cervical ganglionectomy. DESIGN,TIME AND SETTING:A randomized,controlled,animal study was performed at the Immunohistochemistry Laboratory of the School of Life Sciences in Lanzhou University from July 2006 to July 2007. MATERIALS:Doublecortin polyclonal antibody was provided by Santa Cruz Biotechnology,USA; avidin-biotin-peroxidase complex was purchased from Zhongshan Goldenbride Biotechnology, China;Morris water maze was bought from Taimeng Technology,China. METHODS:A total of 20 adult,male,Wistar rats were randomly divided into surgery and control groups,with 10 rats in each group.In the surgery group,the bilateral superior cervical ganglions were transected.In the control group,the superior cervical ganglions were only exposed,but no ganglionectomy was performed. MAIN OUTCOME MEASURES:To examine distribution,morphology,and number of newborn neurons in the dentate gyrus using doublecortin immunohistochemistry at 36 days following surgical procedures.To examine ability of learning and memory in adult rats using the Morris water maze at 30 days following surgical procedures. RESULTS:Doublecortin immunohistochemical results showed that a reduction in the number of doublecortin-positive neurons in the surgery group compared to the control group(P<0.05),while the distribution of doublecortin-positive neurons was identical in the two groups.The surgery group exhibited significantly worse performance in learning and spatial memory tasks compared to the control group(P<0.05). CONCLUSION:Superior cervical ganglionectomy inhibited neurogenesis in the dentate gyrus and decreased learning and memory abilities in adult rats. | Yanping Ding Baoping Shao Shiyuan Yu Shanting Zhao Jianlin Wang | 2009 | Neural Regeneration Research2009，4，9： | 1 |
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