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| 1 | Inverse heat conduction analysis of quenching process using finiteelement and optimization method显示文摘 | Li Huiping Zhao Guoqun Niu Shanting | 2006 | Finite Elements in Analysis and Design2006，42，12： | 1 |
| 2 | FEM simulation of quenching process and experimental verification of simulation results显示文摘 | Li Huiping Zhao Guoqun Niu Shanting | 2007 | Materials Science and Engineering A2007，，： | 1 |
| 3 | Inverse heat conduction analysis of quenching process using finite-element and optimization method 显示文摘 | Li Huiping Zhao Guoqun Niu Shanting | 2006 | Finite Element in Analysis and Design2006，42，： | 1 |
| 4 | FEM simulation of quenching process and experimental verification of simulation results显示文摘 | Li Huiping Zhao Guoqun Niu Shanting | 2007 | Materials Science and Engineering2007，，： | 1 |
| 5 | Inverse Heat Conduction Analysis of Quenching Process Using Finite-element and Optimization Method显示文摘 | Li Huiping Zhao Guoqun Niu Shanting | 2006 | Finite Elements in Analysis and Design2006，42，12： | 1 |
| 6 | FEM simula- tion of quenching process and experimental verification of simulation results显示文摘 | Li Huiping Zhao Guoqun Niu Shanting | 2007 | Materials Science and Engineering A2007，，452453： | 1 |
| 7 | Influence of superior cervical ganglionectomy on hippocampal neurogenesis and learning and memory in adult rats显示文摘BACKGROUND:Studies have shown that neurogenesis in the dentate gyrus plays an important role in learning and memory.However,studies have not determined whether the superior cervical ganglion or the sympathetic nerve system influences hippocampal neurogenesis or learning and memory in adult rats. OBJECTIVE:To observe differences in dentate gyrus neurogenesis,as well as learning and memory,in adult rats following superior cervical ganglionectomy. DESIGN,TIME AND SETTING:A randomized,controlled,animal study was performed at the Immunohistochemistry Laboratory of the School of Life Sciences in Lanzhou University from July 2006 to July 2007. MATERIALS:Doublecortin polyclonal antibody was provided by Santa Cruz Biotechnology,USA; avidin-biotin-peroxidase complex was purchased from Zhongshan Goldenbride Biotechnology, China;Morris water maze was bought from Taimeng Technology,China. METHODS:A total of 20 adult,male,Wistar rats were randomly divided into surgery and control groups,with 10 rats in each group.In the surgery group,the bilateral superior cervical ganglions were transected.In the control group,the superior cervical ganglions were only exposed,but no ganglionectomy was performed. MAIN OUTCOME MEASURES:To examine distribution,morphology,and number of newborn neurons in the dentate gyrus using doublecortin immunohistochemistry at 36 days following surgical procedures.To examine ability of learning and memory in adult rats using the Morris water maze at 30 days following surgical procedures. RESULTS:Doublecortin immunohistochemical results showed that a reduction in the number of doublecortin-positive neurons in the surgery group compared to the control group(P<0.05),while the distribution of doublecortin-positive neurons was identical in the two groups.The surgery group exhibited significantly worse performance in learning and spatial memory tasks compared to the control group(P<0.05). CONCLUSION:Superior cervical ganglionectomy inhibited neurogenesis in the dentate gyrus and decreased learning and memory abilities in adult rats. | Yanping Ding Baoping Shao Shiyuan Yu Shanting Zhao Jianlin Wang | 2009 | Neural Regeneration Research2009，4，9： | 1 |
| 8 | FEM simulation of quenching process and experimental verification of simulation results 显示文摘 | Li Huiping Zhao Guoqun Niu Shanting | 2007 | Materials Science and Engineering A2007，，4： | 1 |
| 9 | Reelin stabilizes the actin cytoskeleton of neuronal processes by Inducing n-cofilin phosphorylation at serine3显示文摘 | Chai Xuejun Forster E Zhao Shanting | 2009 | J Neurosci2009，29，1： | 1 |
| 10 | β‑Hydroxybutyric acid improves cognitive function in a model of heat stress by promoting adult hippocampal neurogenesis显示文摘Heat stress has multiple potential effects on the brain,such as neuroinflammation,neurogenesis defects,and cog-nitive impairment.β-hydroxybutyric acid(BHBA)has been demonstrated to play neuroprotective roles in various models of neurological diseases.In the present study,we investigated the efficacy of BHBA in alleviating heat stress-induced impairments of adult hippocampal neurogenesis and cognitive function,as well as the underlying mecha-nisms.Mice were exposed to 43℃for 15 min for 14 days after administration with saline,BHBA,or minocycline.Here,we showed for the first time that BHBA normalized memory ability in the heat stress-treated mice and attenuated heat stress-impaired hippocampal neurogenesis.Consistently,BHBA noticeably improved the synaptic plasticity in the heat stress-treated hippocampal neurons by inhibiting the decrease of synapse-associated proteins and the density of dendritic spines.Moreover,BHBA inhibited the expression of cleaved caspase-3 by suppressing endoplasmic reticu-lum(ER)stress,and increased the expression of brain-derived neurotrophic factor(BDNF)in the heat stress-treated hippocampus by activating the protein kinase B(Akt)/cAMP response element binding protein(CREB)and methyl-CpG binding protein 2(MeCP2)pathways.These findings indicate that BHBA is a potential agent for improving cogni-tive functions in heat stress-treated mice.The action may be mediated by ER stress,and Akt-CREB-BDNF and MeCP2 pathways to improve adult hippocampal neurogenesis and synaptic plasticity. | Jian Huang Yongji Wu Xuejun Chai Shuai Wang Yongkang Zhao Yan Hou Yue Ma Shulin Chen Shanting Zhao Xiaoyan Zhu | 2022 | Stress Biology2022，2，1： | 0 |
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