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| 1 | The Rice RMR1 Associates with a Distinct Prevacuolar Compartment for the Protein Storage Vacuole Pathway显示文摘从到液泡的 Golgi 仪器或 trans-Golgi 网络(TGN ) 的 vacuolar 蛋白质的运输在植物房间是经由中间的膜界限 prevacuolar 分隔空间(PVC ) 的一个调停受体的过程。排序受体(VSR ) 和受体相同 region-transmembrane domain-RING-H2 (RMR ) 蛋白质的两 vacuolar 被显示了在把存储蛋白质搬运到蛋白质存储液泡(PSV ) 工作,但是很少为 PSV 小径对 PVC 的性质被知道。这里,我们把米饭 RMR1 (OsRMR1 ) 用作一根探针在植物学习 PSV 小径。有特定的 OsRMR1 抗体的 Immunogold 电子显微镜学(他们)证明 OsRMR1 蛋白质在两个大米文化房间和发展中的大米种子与 PVC 的特征在 Golgi 仪器, TGN ,和一个不同细胞器被发现,象蛋白质身体类型 II ( PBII )或在开发大米种子的 PSV 一样。这个细胞器,也在烟草 BY-2 和 Arabidopsis 暂停发现有教养的房间,从 VSR 积极的 multivesicular 是词法上不同的 lysin 的 PVC 或 multivesicular 身体(MVB ) 并且因此为我们说出存储 PVC (sPVC ) 的 PSV 小径代表 PVC。进一步,在 vivo 并且在 vitro,相互作用用蛋白质分泌了进暂停房间表明了的转基因的 BY-2 的文化媒介的截断的 OsRMR1 学习那 OsRMR1 在搬运象 vicilin 一样存储蛋白质作为排序的受体工作。 | Yun Shen Junqi Wang Yu Ding Sze Wan Lo Guillaume Gouzerh Jean-Marc Neuhau Liwen Jiang | 2011 | Molecular Plant2011，4，5： | 5 |
| 2 | Research and pro- gress of cluster algorithms based on granular computing显示文摘 | Ding Shifei Xu Li Zhu Hong Zhang Liwen | 2010 | Inter- national Journal of Digital Content Technology and its Applications2010，4，5： | 1 |
| 3 | Highly sensitive luminescent lanthanide metal-organic framework sensor for L-kynurenine显示文摘L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide metal-organic frameworks([Ln(CHO_(2))_(3)]_(n),Ln=Eu,Gd,and Tb)were designed and obtained,and detailly characterized by single crystal X-ray diffraction(SCXRD),powder X-ray diffraction(PXRD),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),and luminescence spectroscopy.Further study reveals that[Tb(CHO_(2))_(3)]_(n)is a highly selective,ultra-sensitive,of strong anti-interference,highly stable,and non-expensive sensor for prostate cancer marker L-kyn.The limit of detection(LOD)for L-kyn sensing is a highly sensitive value of 1.0×10^(−9)mol/L.Furthermore,the sensing mechanism is discussed in detail. | Ting Tang Min Liu Zhao Chen Xingxiang Wang Chunguang Lai Liwen Ding Chenghui Zeng | 2022 | Journal of Rare Earths2022，40，3： | 1 |
| 4 | Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance显示文摘 | Liwu Fu Yongju Liang Liwen Deng Yan Ding Liming Chen Yanli Ye Xiaoping Yang Qichao Pan | 2004 | Cancer Chemotherapy and Pharmacology2004，，4： | 1 |
| 5 | A Killer-Protector System Regulates Both Hybrid Sterility and Segregation Distortion in Rice显示文摘 | Jiangyi Yang Xiaobo Zhao Ke Cheng Hongyi Du Yidan Ouyang Jiongjiong Chen Shuqing Qiu Jianyan Huang Yunhe Jiang Liwen Jiang Jihua Ding Jia Wang Caiguo Xu Xianghua Li Qifa Zhang | 2012 | Science2012，，6100： | 1 |
| 6 | Effect of longitudinal lift distribution on sonic boom of a canard-wing-stabilator-body configuration显示文摘After the last flight of the Concorde in 2003,sonic boom has been one of the obstacles to the return of a supersonic transport aircraft to service.To reduce the sonic boom intensity to an acceptable level,it is of great significance to study the effect of lift distribution on far-field sonic boom,since lift is one of the most important contributors to an intense sonic boom.Existing studies on the longitudinal lift distribution used low-fidelity methods,such as Whitham theory,and in turn,only preliminary conclusions were obtained,such as that extending the lift distribution can reduce sonic boom.This paper uses a newly developed high-fidelity prediction method to quantitatively study the effect of longitudinal lift distribution on the sonic boom of a Canard-Wing-Stabilator-Body(CWSB)configuration.This high-fidelity prediction method combines near-feld CFD simulation with far-field propagation by solving the augmented Burgers equation.A multipole analysis method is employed for the extraction of near-field waveform in order to reduce computational cost.Seven configurations with the same total lift but different distributions are studied,and the quantitative relationship between the longitudinal lift distribution and far-field sonic boom intensity is investigated.It is observed that a small lift generated by the stabilator can prevent aft-stabilator and aft-fuselage shocks from merging,while the balanced lift generated by the canard and wing can effectively keep the corresponding shocks further apart,which is beneficial for reducing both the on-track and off-track sonic boom.In turn,the acoustic level perceived at the ground can be reduced by 5.9 PLdB on-track and 5.4 PLdB off-track,on average. | Liwen ZHANG Zhonghua HAN Jianling QIAO Wenping SONG Yulin DING Xuehe WANG | 2023 | Chinese Journal of Aeronautics2023，36，6： | 1 |
| 7 | Preparation and Electrical Transport Properties of Perovskite Oxide Ln0.5Sr0.5CoO3显示文摘 | Zhu Zhiqiang Ding Tiezhu Zhao Qian Zhang Liwen Wang Qiang | 2006 | Journal of Rare Earths2006，24，4： | 0 |
| 8 | Porous Y_2O_3 microcubes:synthesis and characterization显示文摘In this work,a facile route using a simple solvothermal reaction and sequential heat treatment process to prepare porous Y2O3 microcubes is presented.The as-synthesized products were characterized by X-ray powder diffraction(XRD) ,scanning electronic microscope(SEM) ,en-ergy dispersive spectrometer(EDS) ,thermogravimetric analysis(TG) ,and differential thermal analysis(DTA) .The thermal decomposition process of the Y2O3 precursor was investigated.SEM results demonstrated that the as-prepared porous Y2O3 microcubes were with an aver-age width of about 20 μm and thickness of about 8 μm.It was found that the morphology of the Y2O3 precursor could be readily tuned by varying the molar ratio of S 2 O 82-to Y3+.Y2O3:Eu3+(6.6%) microcubes were also prepared and their photoluminescence properties were investigated. | DENG Bin DING Liwen CHEN Jianjun ZHONG Shengliang | 2011 | Rare Metals2011，30，6： | 0 |
| 9 | Applications of bioinspired approaches and challenges inmedical devices显示文摘Urgent requirements of medical devices Precision medicine has gradually become a development strategy in many countries and attracted worldwide attention in recent years due to the increasing concerns in public health.Although the definition of precision medicine has less or more difference from the viewpoints of different fields,the demands on the properties of medical devices or medical materials involving biocompatibility and anti-thrombosis are gradually growingmuch more diverse and much more urgent than ever[1].This trend brings up many new research topics about materials,mechanical systems and sensors to develop advanced medical devices.How to design and on-demand fabricate the bio-materials,bio-interface and bio-systems to meet the urgent demands of medical devices is still a challenge for us. | Huawei Chen Yi Zhang Liwen Zhang Xilun Ding Deyuan Zhang | 2021 | Bio-Design and Manufacturing2021，4，1： | 0 |
| 10 | Mitochondrial sensitive probe with aggregation-induced emission characteristics for early brain diagnosis of Parkinson’s disease显示文摘The early diagnosis of Parkinson’s disease(PD)provides opportunities for early intervention to slow the progression of neurological degeneration in patients,particularly as the aging population increases in our society.Among a series of pathological features of PD,mitochondria abnormalities have been identified as central event that occurs at the early stage of PD.However,the method for detecting mitochondrial abnormalities-associated early PD has not been fully developed.We herein report a specifically mitochondrial targeting probe(named TPA-BT-SCP)that is able to characterize mitochondria abnormalities for early diagnosis of PD and monitor PD neurodegenerative progress.The probe is an aggregation-induced emission(AIE)probe with a strong positive charge,a 3D distorted molecular structure,and a separated HOMO-LUMO distribution,designed with unique molecular design guidelines.Our research demonstrated that TPA-BT-SCP could emit stable and strong fluorescence,and rapidly accumulate in mitochondria due to the negative charge.After intranasal administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mice,TPA-BT-SCP successfully bypassed the blood−brain barrier to light up the brain,allowing the grading of PD severity based on its high sensitivity.Taken together,this work develops a novel AIE probe that exhibits dramatically high sensitivity to mitochondrial changes and enables noninvasive diagnosis of early PD in the brain. | Liwen Huang Yutong Zhou Di Jiao Jing Ren Yilin Qi Heping Wang Yang Shi Dan Ding Xue Xue | 2024 | Aggregate2024，5，1： | 0 |
| 11 | Methylprednisolone intrathecal injections suppress neuronal apoptosis following acute spinal cord injury显示文摘High dose methylprednisolone intravenous injections are effective in treating acute spinal cord injury but can have severe side effects.In this study,we investigated intrathecal delivery of methylprednisolone for the treatment of spinal cord injury.In particular,we examined the effects of varying doses of methylprednisolone intrathecal injections on neuronal apoptosis induced by secondary damage.The results demonstrate that intrathecal injections inhibit the expression of interleukin-1β,significantly lower expression of caspase-3,and reduce the number of apoptotic neurons.High dose methylprednisolone (0.75mg/μL) was much more effective at reducing neuronal apoptosis than low dose methylprednisolone (0.01mg/μL). | Xinghua Song Jianjun Zhang Liwen Ding Li Cao Xiaoxiong Xu Hao Wen | 2011 | Neural Regeneration Research2011，6，17： | 0 |
| 12 | Integrated Transcriptome and Small RNA Sequencing Analyses Reveals Insights into the Molecular Mechanism of Seed Germination in Mung Bean显示文摘During the life cycle of a plant,seed germination is crucial.Upon ingestion of water,the dry seeds resumed energy metabolism and cellular repair.To dissect the complex mechanisms at the very beginning of seed germination,two approaches including transcriptome and small RNA sequencing were conducted during the water imbibition process of mung bean seeds compared with dry seed.The transcriptome sequencing analysis identified 10,108 differentially expressed genes(DEGs)between dry and imbibed mung bean seeds.KEGG enrichment analyses demonstrated numerous DEGs involved in hormone signaling pathways,carbohydrate,and energy metabolism.Out of the total DEGs,129 genes were investigated to involve in abscisic acid,gibberellin,and ethylene pathways,with 56 genes involved in glycolysis and TCA cycle.Through the analysis of small RNA sequencing among different samples,there were 284 miRNAs found in the imbibed and dried seeds of mung bean containing 213 known and 71 novel miRNAs.From comparison between the two types of seeds,51 miRNAs were differentially expressed.The integrated analyses of transcriptome and miRNAome data showed that 23 DEGs are the putative target genes of 8 miRNAs including miR156,miR171b-3p,miR166e-3p,miR169-1,etc.QRT-PCR was used to validate several DEGs and miRNAs.The data suggested that the seed imbibition process is regulated by a variety of DEGs and microRNAs.Meanwhile,we hope to gain a deeper insight into how mung bean seeds germinate in order to optimize seed growth. | Yanyan Pu Liwen Wang Leilei Li Yujun Si Shubin Xie Yunzhe Cong Dong Wang Yongchao Gong Rumei Tian Xue Chen Xiaoyan Zhang Min Liu Hanfeng Ding Nana Li | 2023 | Phyton-International Journal of Experimental Botany2023，92，6： | 0 |
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