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| 1 | Experimental and numerical study of failure behavior and mechanism of coal under dynamic compressive loads显示文摘A comprehensive understanding of the failure behavior and mechanism of coal is a prerequisite for dealing with dynamic problems in mining space.In this study,the failure behavior and mechanism of coal under uniaxial dynamic compressive loads were experimentally and numerically investigated.The experiments were conducted using a split Hopkinson pressure bar(SHPB)system.The results indicated that the typical failure of coal is lateral and axial at lower loading rates and totally smashed at higher loading rates.The further fractography analysis of lateral and axial fracture fragments indicated that the coal failure under dynamic compressive load is caused by tensile brittle fracture.In addition,the typical failure modes of coal under dynamic load were numerically reproduced.The numerical results indicated that the axial fracture is caused directly by the incident compressive stress wave and the lateral fracture is caused by the tensile stress wave reflected from the interface between coal specimen and transmitted bar.Potential application was further conducted to interpret dynamic problems in underground coal mine and it manifested that the lateral and axial fractures of coal constitute the parallel cracks in the coal mass under roof fall and blasting in mining space. | Junjun Feng Enyuan Wang Qisong Huang Houcheng Ding Xiangyang Zhang | 2020 | International Journal of Mining Science and Technology2020，30，5： | 13 |
| 2 | Influence of Vehicle Parameters on Critical Hunting Speed Based on Ruzicka Model显示文摘While introducing foreign advanced technology and cooperating with Chinese famous research institutes,the high-speed vehicles are designed and take the major task of passenger transport in China.In high-speed vehicle,the characteristic of shock absorber is an important parameter which determines overall behavior of the vehicle.The most existing researches neglect the influence of the series stiffness of the shock absorber on the vehicle dynamic behavior and have one-sided views on the equivalent conicity of wheel tread.In this paper,a high speed passenger vehicle in China is modeled to investigate the effect of the parameters taking series hydraulic shock absorber stiffness into consideration on Ruzicka model.Using the vehicle dynamic model,the effect of main suspension parameters on critical speed is studied.In order to verify the reasonableness of shock absorber parameter settings,vibration isolation characteristics are calculated and the relationship between suspension parameters and the vehicle critical hunting speed is studied.To study the influence of equivalent conicity on vehicle dynamic behavior,a series of wheel treads with different conicities are set and the vehicle critical hunting speeds with different wheel treads are calculated.The discipline between the equivalent conicity of wheel tread and critical speed are obtained in vehicle nonlinear system.The research results show that the critical speed of vehicle much depends on wheelset positioning stiffness and anti-hunting motion damper,and the series stiffness produces notable effect on the vehicle dynamic behavior.The critical speed has a peak value with the equivalent conicity increasing,which is different from the traditional opinion in which the critical speed will decrease with the conicity increasing.The relationship between critical speed and conicity of wheel tread is effected by the suspension parameters of the vehicle.The study results obtained offer a method and useful data to designing the parameters of the high speed vehicle and simulation study. | CUI Dabin LI Li JIN Xuesong XIAO Xinbiao DING Junjun | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 12 |
| 3 | Energy dissipation rate: An indicator of coal deformation and failure under static and dynamic compressive loads显示文摘Dynamic disasters in Chinese coal mines pose a significant threat to coal productivity. Thus, a thorough understanding of the deformation and failure processes of coal is necessary. In this study, the energy dissipation rate is proposed as a novel indicator of coal deformation and failure under static and dynamic compressive loads. The relationship between stress-strain, uniaxial compressive strength, displacement rate, loading rate, fractal dimension, and energy dissipation rate was investigated through experiments conducted using the MTS C60 tests(static loads) and split Hopkinson pressure bar system(dynamic loads). The results show that the energy dissipation rate peaks are associated with stress drop during coal deformation, and also positively related to the uniaxial compressive strength. A higher displacement rate of quasi-static loads leads to an initial increase and then a decrease in energy dissipation rate, whereas a higher loading rate of dynamic loads results in larger energy dissipation rate. Theoretical analysis indicates that a sudden increase in energy dissipation rate suggests partial fracture occurring within coal under both quasi-static and dynamic loads. Hence, the energy dissipation rate is an essential indicator of partial fracture and final failure within coal, as well as a prospective precursor for catastrophic failure in coal mine. | Feng Junjun Wang Enyuan Chen Xia Ding Houcheng | 2018 | International Journal of Mining Science and Technology2018，28，3： | 12 |
| 4 | Oct4 links multiple epigenetic pathways to the pluripotency network显示文摘Oct4 是在干细胞自强, pluripotency,和体的房间 reprogramming 起基本作用的一个著名抄写因素。然而,有限信息在联系 Oct4 的蛋白质建筑群和他们支配 Oct4 的批评规章的活动的内在的蛋白质蛋白质相互作用上是可得到的。这里,我们采用了与集体 spectrometry 相结合在老鼠净化 Oct4 蛋白质建筑群的一条改进亲密关系纯化途径胚胎的干细胞(mESCs ) ,并且发现了为 mESCs 的自强和 pluripotency 重要的许多新奇 Oct4 搭挡。尤其是,我们发现那 Oct4 与多重修改染色质的建筑群被联系与记录以及最新在干细胞维护和体的房间 reprogramming 证明意义功能。我们的学习建立一个稳固的生物化学的基础为基因并且干细胞 pluripotency 的 epigenetic 规定并且为探索其他的基于因素的 reprogramming 策略提供一个框架。 | Junjun Ding HuileiXu Francesco Faiola Avi Ma'ayan Jianlong Wang | 2012 | Cell Research2012，22，1： | 6 |
| 5 | Sialylation is involved in cell fate decision during development, reprogramming and cancer progression显示文摘Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a biologically important modification that is involved in embryonic development, neurodevelopment, reprogramming, oncogenesis and immune responses. In this review, we have given a comprehensive overview of the current literature on the involvement of sialylation in cell fate decision during development, reprogramming and cancer progressionSialylation is essential for early embryonic development and the deletion of UDP-GIcNAc 2-epimerase, a rate-limiting enzyme in sialic acid biosynthesis, is embryonically lethal. Furthermore, the sialyltransferase ST6GAL1 is required for somatic cell reprogramming, and its downregulation is associated with decreased reprogramming efficiency. In addition, sialylation levels and patterns are altered during cancer progression, indicating the potential of sialylated molecules as cancer biomarkers. Taken together, the current evidences demonstrate that sialylation is involved in crucial cell fate decision. | Fenjie Li Junjun Ding | 2019 | Protein & Cell2019，10，8： | 4 |
| 6 | The influence of Mozart’s sonata K.448 on visual attention: An ERPs study显示文摘 | Weina Zhu Lun Zhao Junjun Zhang Xiaojun Ding Haiwei Liu Enzhi Ni Yuanye Ma Changle Zhou | 2008 | Neuroscience Letters2008，，1： | 1 |
| 7 | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase显示文摘DNA methylation 和 demethylation 在哺乳动物调整许多关键生物过程并且被连接到许多疾病。活跃 DNA demethylation 被相信被 TET 蛋白质和可以与在真菌催化 5caU 的去碳酸基到 U 的 isoorotate decarboxylase (IDCase ) 在顺序,结构和催化机制分享一些类似的通常认为的 DNA decarboxylase 催化。我们这里与 5caU, U,和禁止者 5-nitro-uracil 在 apo 形式或在建筑群从 Cordyceps militaris 和 Metarhizium anisopliae 报导野类型、变异的 IDCases 的结构。IDCases 采用一典型(β /α) amidohydrolase 总科和功能的 8 桶褶层作为 dimers。Zn 2+ 在活跃地点被绑并且由四严格地保存的残余协调了,一条毒蛇并且三他的。底层被几严格地保存的残余认出。在活跃地点的关键残余的功能的角色被 mutagenesis 和生物化学的研究验证。基于结构、生物化学的数据,我们在场第一次为 IDCases 的去碳酸基的新奇催化机制,它可能也适用于 amidohydrolase 总科的另外的成员。另外,我们 IDCases 能催化的生物化学的数据表演到有弱活动的 C 虽然的 5caC 的去碳酸基,它在为到由酶的 C 的 5caC 的直接去碳酸基的 vitro 证据是第一。这些调查结果在在哺乳动物的潜在的 DNA decarboxylase 的鉴定是珍贵的。 | Shutong Xu Wenjing Li Junjun Zhu Rong Wang Zheng Li Guo-Liang Xu Jianping Ding | 2013 | Cell Research2013，23，11： | 1 |
| 8 | Effects of oestrogen on long noncoding RNA expression in oestrogen receptor alpha-positive ovarian cancer cells显示文摘 | Junjun Qiu Lechi Ye Jingxin Ding Weiwei Feng Ying Zhang Tianjiao Lv Jiajia Wang Keqin Hua | 2013 | Journal of Steroid Biochemistry and Molecular Biology2013，，： | 1 |
| 9 | Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation显示文摘Understanding the regulatory networks for germ cell fate specification is necessary to developing strategies for improving the efficiency of germ cell production in vitro.In this study,we developed a coupled screening strategy that took advantage of an arrayed bi-molecular fluorescence complementation(BiFC)platform for protein-protein interaction screens and epiblast-like cell(EpiLC)-induction assays using reporter mouse embryonic stem cells(mESCs).Investigation of candidate interaction partners of core human pluripotent factors OCT4,NANOG,KLF4 and SOX2 in EpiLC differentiation assays identified novel primordial germ cell(PGC)-inducing factors including BEN-domain(BEND/Bend)family members.Through RNA-seq,ChIP-seq,and ATAC-seq analyses,we showed that Bend5 worked together with Bend4 and helped mark chromatin boundaries to promote EpiLC induction in vitro.Our findings suggest that BEND/Bend proteins represent a new family of transcriptional modulators and chromatin boundary factors that participate in gene expression regulation during early germline development. | Guang Shi Yaofu Bai Xiya Zhang Junfeng Su Junjie Pang Quanyuan He Pengguihang Zeng Junjun Ding Yuanyan Xiong Jingran Zhang Jingwen Wang Dan Liu Wenbin Ma Junjiu Huang Zhou Songyang | 2022 | Protein & Cell2022，13，10： | 1 |
| 10 | The dynamics of three-dimensional chromatin organization and phase separation in cell fate transitions and diseases显示文摘Cell fate transition is a fascinating process involving complex dynamics of three-dimensional(3D)chromatin organization and phase separation,which play an essential role in cell fate decision by regulating gene expression.Phase separation is increasingly being considered a driving force of chromatin folding.In this review,we have summarized the dynamic features of 3D chromatin and phase separation during physiological and pathological cell fate transitions and systematically analyzed recent evidence of phase separation facilitating the chromatin structure.In addition,we discuss current advances in understanding how phase separation contributes to physical and functional enhancerpromoter contacts.We highlight the functional roles of 3D chromatin organization and phase separation in cell fate transitions,and more explorations are required to study the regulatory relationship between 3D chromatin organization and phase separation. | Xiaoru Ling Xinyi Liu Shaoshuai Jiang Lili Fan Junjun Ding | 2022 | Cell Regeneration2022，11，1： | 0 |
| 11 | An Efficient Webpage Classification Algorithm Based on LSH显示文摘With the explosive growth of Internet information, it is more and more important to fetch real-time and related information. And it puts forward higher requirement on the speed of webpage classification which is one of common methods to retrieve and manage information. To get a more efficient classifier, this paper proposes a webpage classification method based on locality sensitive hash function. In which, three innovative modules including building feature dictionary, mapping feature vectors to fingerprints using Localitysensitive hashing, and extending webpage features are contained. The compare results show that the proposed algorithm has better performance in lower time than the naive bayes one. | Junjun Liu Haichun Sun Zhijun Ding | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 0 |
| 12 | Tet酶调控端粒和基因组稳定性的作用和机制显示文摘Tets家族催化5-甲基胞嘧啶转变为5-羟甲基胞嘧啶。在小鼠胚胎干细胞中单独干扰Tet1或/和Tet2,伴随着端粒重组下降,导致端粒长度缩短和基因组稳定性异常。 | Jiao Yang Renpeng Guo Hua Wang Xiaoying Ye Zhongcheng Zhou Jiameng Dan Haiying Wang Peng Gong Wei Deng Yu Yin Shi Qing Mao Lingbo Wang Junjun Ding Jinsong Li David L.Keefe Meelad M.Dawlaty Jianlong Wang Guo Liang Xu 刘林 | 2017 | 科学新闻2017，19，4： | 0 |
| 13 | Influence of Curve Geometric Parameters on Curving Performance of Sub-frame Radial Bogie显示文摘Based on the theory of vehicle-track coupling dynamics,the coupling dynamic model of the freight car mounted with the sub-frame bogies and the numerical model of curved track were established,utilizing the fast numerical integration method,the curving performance of the vehicle was simulated to study the influence of the curve geometric parameters such as curve radius,transition curve length and superelevation of outer rail on the wheel-rail dynamic interaction.The simulation results indicate that:(1)Increasing the curve radius can decrease the wheel-rail wear,but the effect will weaken while the curve radius is greater than 800m.(2)If the transition curve length is less than 30m,vibrations will appear at the transition-circle connecting point,and the smaller the transition length,the bigger the vibrations,the worse the wheel-rail wear,but when the length is bigger than 50m,its further variation has very little effect on wheel-rail wear.(3)The superelevation of outer rail can affect the distribution and difference of the inner and outer wheel-rail forces,and too large deficient or excessive superelevation will worsen the wheel-rail wear either.However,an appropriate deficient superelevation of outer rail(e.g.<20mm)is helpful to reduce the wheel-rail wear,which is consistent with the engineering practice of settling a certain deficient superelevation value. | Chunlei YANG Yunhua HUANG Junjun DING | 2021 | Mechanical Engineering Science2021，3，1： | 0 |
| 14 | Predicting single-phase solid solutions in as-sputtered high entropy alloys:High-throughput screening with machine-learning model显示文摘Searching for single-phase solid solutions(SPSSs)in high-entropy alloys(HEAs)is a prerequisite for the intentional design and manipulation of microstructures of alloys in vast composition space.However,to date,reported SPSS HEAs are still rare due to the lack of reliable guiding principles for the synthesis of new SPSS HEAs.Here,we demonstrate an ensemble machine-learning method capable of discovering SPSS HEAs by directly predicting quinary phase diagrams based only on atomic composition.A total of 2198 experimental structure data are extracted from as-sputtered quinary HEAs in the literature and used to train a random forest classifier(termed AS-RF)utilizing bagging,achieving a prediction accuracy of 94.6%compared with experimental results.The AS-RF model is then utilized to predict 224 quinary phase diagrams including∼32,000 SPSS HEAs in Cr-Co-Fe-Ni-Mn-Cu-Al composition space.The extrapolation capability of the AS-RF model is then validated by performing first-principle calculations using density functional theory as a benchmark for the predicted phase transition of newly predicted HEAs.Finally,interpretation of the AS-RF model weighting of the input parameters also sheds light on the driving forces behind HEA formation in sputtered systems with the main contributors being:valance electron concentration,work function,atomic radius difference and elementary symmetries. | Ji-Chang Ren Junjun Zhou Christopher J.Butch Zhigang Ding Shuang Li Yonghao Zhao Wei Liu | 2023 | Journal of Materials Science & Technology2023，，7： | 0 |
| 15 | CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation显示文摘Chromatin is spatially organized into three-dimensional structures at different levels including A/B compartments, topologically associating domains and loops. The canonical CTCF-mediated loop extrusion model can explain the formation of loops. However, the organization mechanisms underlying long-range chromatin interactions such as interactions between A–A compartments are still poorly understood. Here we show that different from the canonical loop extrusion model, RYBP-mediated phase separation of CTCF organizes inter-A compartment interactions. Based on this model, we designed and verified an induced CTCF phase separation system in embryonic stem cells (ESCs), which facilitated inter-A compartment interactions, improved self-renewal of ESCs and inhibited their differentiation toward neural progenitor cells. These findings support a novel and non-canonical role of CTCF in organizing long-range chromatin interactions via phase separation. | Chao Wei Lumeng Jia Xiaona Huang Jin Tan Mulan Wang Jing Niu Yingping Hou Jun Sun Pengguihang Zeng Jia Wang Li Qing Lin Ma Xinyi Liu Xiuxiao Tang Fenjie Li Shaoshuai Jiang Jingxin Liu Tingting Li Lili Fan Yujie Sun Juntao Gao Cheng Li Junjun Ding | 2022 | Cell Research2022，32，8： | 0 |
| 16 | PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions显示文摘Polycomb group(PcG)ring finger protein 6(PCGF6),though known as a member of the transcription-re-pressing complexes,PcG,also has activation function in regulating pluripotency gene expression.However,the mechanism underlying the activation function of PCGF6 is poorly understood.Here,we found that PCGF6 co-localizes to gene activation regions along with pluripotency factors such as OCT4.In addition,PCGF6 was recruited to a subset of the super-enhancer(SE)regions upstream of cell cycle-associated genes by OCT4,and increased their expression.By combining with promoter capture Hi-C data,we found that PCGF6 activates cell cycle genes by regulating SE-promoter interactions via 3D chromatin.Our fin dings highlight a novel mechanism of PcG protein in regulating pluripotency,and provide a research basis for the therapeutic application of pluripotent stem cells. | Xiaona Huang Chao Wei Fenjie Li Lumeng Jia Pengguihang Zeng Jiahe Li Jin Tan Tuanfeng Sun Shaoshuai Jiang Jia Wang Xiuxiao Tang Bin Liu Limin Rong Cheng Li Junjun Ding | 2019 | Protein & Cell2019，10，10： | 0 |
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