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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | Calibration of near infrared reflectance spectroscopy to estimate nitrogen concentration in potato tissues显示文摘 | YOUNG M W MACKRRON D K L DAVIES H V | 1997 | PotatoResearch1997，，40： | 1 |
| 5 | Effect of variety,nitrogen fertilizer and various agronomic factors on the nutritive value of husked and naked oats grain显示文摘 | T W Davies R M Laverick | 2004 | Animal Feed Science and Technology2004，113，： | 1 |
| 6 | Calibration of a calorimeter for thermal resisitance measurements of advanced insulation panels显示文摘 | Ellis M W Davis A H | 2000 | HVACR research2000，6，3： | 1 |
| 7 | Quantitativemonitoring of gene expression patterns with a complementary DNA microarray显示文摘 | Schena M Shalon D Davis R W Brown P O | 1995 | Science1995，270，： | 1 |
| 8 | Quantitative monitoring of gene expressionpatterns with a complementary DNA microarray显示文摘 | Schena M Shalon D Davis R W | 1999 | Science1999，270，5235： | 1 |
| 9 | An electrophoretic karyotype of Neurospora crassa显示文摘 | Orbach M J Vollrath D Davis R W | 1988 | Mol Cell Biol1988，，8： | 1 |
| 10 | Hollow metal microneedles for insulin delivery to diabetic rats 显示文摘 | Davis S P Martanto W Allen M G | 2005 | IEEE Transactions on Biomedical Engineering2005，52，5： | 1 |
| 11 | Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarmy 显示文摘 | SCHENA M SHALQN D DAVIS R W | 1995 | Sclence1995，270，5235： | 1 |
| 12 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray显示文摘 | SCHENA M SHALON D DAVIS R W | 1995 | Science1995，270，5235： | 1 |
| 13 | Nonlinear wavelet transforms for image coding via lifting显示文摘 | Roger L C Davis G M Sweldens W | 2003 | IEEE Transactions on Image Process2003，12，12： | 1 |
| 14 | Universal amplification and analysis of pathogen 16S rRNA for classification and identification of mycoplasmalike organisms 显示文摘 | Lee I M Hammond R W Davis R E | 1993 | Phytopathology1993，83，8： | 1 |
| 15 | A new thermal rating approach:The realtime thermal rating system for strategic overheadconductor transmission lines-Part II : Steady statethermal rating program 显示文摘 | Davis M W | 1977 | IEEE Trans on PowerApparatus and Systems1977，96，3： | 1 |
| 16 | Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer显示文摘 | SCHENA M SHALON D DAVIS R W | 1995 | Science1995，270，5235： | 1 |
| 17 | A numerical investiga- tion of the effects of cas-phase particle formation on silicon film depo- sition from silane显示文摘 | Kremer D M Davis R W Moore E F | 2003 | J Cryst Growth2003，247，333： | 1 |
| 18 | Determinationof the sedimentary microbial biomass by extractible lipidphosphate显示文摘 | White D C Davis W M Nickels J S | 1979 | Oecologia1979，40，1： | 1 |
| 19 | A point and line source model of laser key hole welding显示文摘 | Steen W M Dowden J Davis M | 1988 | Journal of Physics D: Applied Physics1988，21，8： | 1 |
| 20 | Quantitative monitoring of gene expression patterns with acomplementary DNA microarray显示文摘 | Schena M Shalon D Davis R W | 1995 | Science1995，270，5235： | 1 |
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