|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 2 | Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase?显示文摘 | Yasser H Shaib Jessica A Davila Kathryn McGlynn Hashem B El-Serag | 2003 | Journal of Hepatology2003，，3： | 3 |
| 3 | Comparison of the utility of covered metal stents versus uncovered metal stents in the management of malignant biliary strictures in 749 patients显示文摘 | Jeffrey H. Lee Somashekar G. Krishna Amanpal Singh Harshad S. Ladha Rebecca S. Slack Srinivas Ramireddy Gottumukkala S. Raju Marta Davila William A. Ross | 2013 | Gastrointestinal Endoscopy2013，，2： | 3 |
| 4 | ASGE guideline: the role of endoscopy in the surveillance of premalignant conditions of the upper GI tract显示文摘 | William K. Hirota Marc J. Zuckerman Douglas G. Adler Raquel E. Davila James Egan Jonathan A. Leighton Waqar A. Qureshi Elizabeth Rajan Robert Fanelli Jo Wheeler-Harbaugh Todd H. Baron Douglas O. Faigel | 2006 | Gastrointestinal Endoscopy2006，，4： | 2 |
| 5 | Acute exacerbation and reactivation of chronic hepatitis C virus infection in cancer patients显示文摘 | Parag Mahale Dimitrios P. Kontoyiannis Roy F. Chemaly Ying Jiang Jessica P. Hwang Marta Davila Harrys A. Torres | 2012 | Journal of Hepatology2012，，6： | 2 |
| 6 | Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: A population-based study显示文摘 | Jessica A. Davila Robert O. Morgan Yasser Shaib Katherine A. McGlynn Hashem B. El–Serag | 2004 | Gastroenterology2004，，5： | 2 |
| 7 | ASGE Guideline: the role of endoscopy in the patient with lower-GI bleeding显示文摘 | Raquel E. Davila Elizabeth Rajan Douglas G. Adler James Egan William K. Hirota Jonathan A. Leighton Waqar Qureshi Marc J. Zuckerman Robert Fanelli Jo Wheeler-Harbaugh Todd H. Baron Douglas O. Faigel | 2005 | Gastrointestinal Endoscopy2005，，： | 2 |
| 8 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 9 | EUS评估上皮下病变组织取样的诊断效率:钳夹活检与内镜黏膜下切除的比较 | Cantor M.J. Davila R.E. Faigel D.O. 王晓君 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，11： | 2 |
| 10 | ASGE guideline: the role of ERCP in diseases of the biliary tract and the pancreas显示文摘 | Douglas G. Adler Todd H. Baron Raquel E. Davila James Egan William K. Hirota Jonathan A. Leighton Waqar Qureshi Elizabeth Rajan Marc J. Zuckerman Robert Fanelli Jo Wheeler-Harbaugh Douglas O. Faigel | 2005 | Gastrointestinal Endoscopy2005，，1： | 2 |
| 11 | Yield of tissue sampling for subepithelial lesions evaluated by EUS: a comparison between forceps biopsies and endoscopic submucosal resection 显示文摘 | Michael J. Cantor Raquel E. Davila Douglas O. Faigel | 2006 | Gastrointestinal Endoscopy2006，，1： | 2 |
| 12 | Extended iliufemoral versus triradiate approaches in management of associated acetabular fractures显示文摘 | Alonso JE Davila R Bradley E | 1994 | Clin Orthop Relat Res1994，305，： | 1 |
| 13 | Neurotrophic effects of L-dopa in postnatal midbrain dopamine/cortical astrocyte co-cultures 显示文摘 | Mena MA Davila V Sulzer D | 1997 | J Neurochem1997，69，： | 1 |
| 14 | Chromoendoscopy显示文摘 | Davila RE | 2009 | Gastrointest Endosc Clin N Am2009，19，2： | 1 |
| 15 | Epicardial catheter ablation of ventricular tachycardia显示文摘 | DAvila A | 2008 | Heart Rhythm2008，5，6： | 1 |
| 16 | Evaluation of os- seous metastasis in bone scintigraphy显示文摘 | Davila D Antoniou A Chaudhry MA | 2015 | Semin Nucl Med2015，45，1： | 1 |
| 17 | Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease显示文摘 | Khor CC Davila S Breunis WB | 2011 | Nat Genet2011，43，12： | 1 |
| 18 | A positive feedback mechanism that regulates expression of miR-9 during neurogenesis显示文摘 | Davila JL Goff LA Ricupero CL | 2014 | PLo S One2014，9，94： | 1 |
| 19 | ASGE guideline:Colorectal cancer screening and surveillance显示文摘 | Davila R E Rajan E Baron T H | 2006 | Gastrointest Endosc2006，63，4： | 1 |
| 20 | GI Stromal tumors显示文摘 | DAVILA RE FAIGEL D | 2003 | Gastrointest Endose2003，58，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员