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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 4 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 5 | The Use of Simvastatin for the Prevention of Gallstones in the Lithogenic Prairie Dog Model显示文摘 | Kurt G Davis MD Thomas M Wertin MD John P Schriver MD FACS | 2003 | Obesity Surgery2003，，6： | 2 |
| 6 | Calcium intake and body weight显示文摘 | DAVIES K M HEANEY R P RECKER R R | 2000 | Journal of Clinical Endocrinology and Metabolism2000，85，： | 2 |
| 7 | Relation of cerebral vasospasm to subaraclmoid hemorrhage visualized by computerized to mographic scanning显示文摘 | FISHER C M KISTLER J P DAVIS J M | 1980 | Neurosurgery1980，6，： | 1 |
| 8 | Quantitativemonitoring of gene expression patterns with a complementary DNA microarray显示文摘 | Schena M Shalon D Davis R W Brown P O | 1995 | Science1995，270，： | 1 |
| 9 | Differentiating infection from vaccination in foot-and-mouth disease by the detection of antibodies to the non-structural protein 3D,3AB and 3ABC in ELISA using antigens expressed in baculovirus显示文摘 | Mackey D K J Forsyth M A Davies P R | 1998 | Arch Virol1998，143，： | 1 |
| 10 | Fluctuating resources in plant communities: a general theory of invisibility显示文摘 | Davis M A Grime J P Thompson K | 2000 | Journal of Ecology2000，88，： | 1 |
| 11 | Hollow metal microneedles for insulin delivery to diabetic rats 显示文摘 | Davis S P Martanto W Allen M G | 2005 | IEEE Transactions on Biomedical Engineering2005，52，5： | 1 |
| 12 | TFE3 fusions activate METsignaling by transcriptional upregulation,defining another class oftumors as candidates for therapeutic MET inhibition显示文摘 | Tsuda M Davis IJ Argani P | 2007 | CancerRes2007，67，3： | 1 |
| 13 | Absence of radius and ulna in mice lacking Hoxa-11 and Hoxd-11显示文摘 | Davis A P Witte D P Hsieh-Li H M | 1995 | Nature1995，375，6534： | 1 |
| 14 | Operations of an airborne bistatic adjunct to space based radar显示文摘 | Hartnett M P Davis M E | 2003 | IEEE Radar Conference2003，，5： | 1 |
| 15 | Transmeno- pausal changes in the trabecular bone structure显示文摘 | AKHTER M P LAPPE J M DAVIES K M | 2007 | Bone2007，41，1： | 1 |
| 16 | Hydroperoxidase Activities o Ferrihemes: Heine Analogs of Peroxidase Enzyme Intermediate显示文摘 | Jones P Mantle D Davies D M | 1977 | Biochemistry1977，16，18： | 1 |
| 17 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 18 | Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression显示文摘 | Paoloni M Davis S Lana S Withrow S Sangiorgi L Picci P Hewitt S Triche T Meltzer P Khanna C | | 0，，： | 1 |
| 19 | Rotating leadership and collabora- tive innovation recombination processes in symbiotic relationships 显示文摘 | DAVIS J P EISENHARDT K M | 2011 | Administrative Science Quarterly2011，56，2： | 1 |
| 20 | A computer simulation of multi-ship encounters显示文摘 | DAVIS P V DOVE M J STOCKEL C T | 1982 | Journal of Navigation1982，35，： | 1 |
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