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| 1 | Discovery of a pterodactylid pterosaur from the Yixian Formation of western Liaoning,China显示文摘A well-preserved pterosaur with nearly complete skull is described from the Lower Cretaceous Yixian Formation at Sihetun in western Liaoning. It is characterized by a low and long crestless skull, slender and pointed teeth, long metacarpal, nearly equal length of metatarsals I -III and short pedal digit V. It is referred to a new genus and species of the family Pterodactylidae: Haopterus gracilis gen. et sp. nov. This is the first pterosaur with a nearly complete skull from the Jehol Biota; it also represents the first non-controversial fossil record of Pterodactylidae in Asia. Haopterus is more derived than Pterodactylus from the Late Jurassic Solnhofen in Germany. This discovery extends the distribution of the family Pterodactylidae from Europe and Africa to Asia and its latest occurrence from the Late Jurassic to the Early Cretaceous. The discovery of Haopterus gracilis provides further evidence for the study of the originand radiation of the Jehol Biota; it also sheds new light on the evolution and | WANG Xiaolin & LU Junchang1. Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China 2. College of Earth Sciences and Resources, China University of Geo-sciences, Beijing 100083, China 3. Department of Geological Sciences, Southern Methodist University, Dallas, TX 75275, USA | 2001 | Chinese Science Bulletin2001，46，13： | 17 |
| 2 | Mitochondrial uncoupling protein 2 and pancreatic cancer:A new potential target therapy显示文摘Overall 5-years survival of pancreatic cancer patients is nearly 5%,making this cancer type one of the most lethal neoplasia.Furthermore,the incidence rate of pancreatic cancer has a growing trend that determines a constant increase in the number of deceases caused by this pathology.The poor prognosis of pancreatic cancer is mainly caused by delayed diagnosis,early metastasis of tumor,and resistance to almost all tested cytotoxic drugs.In this respect,the identification of novel potential targets for new and efficient therapies should be strongly encouraged in order to improve the clinical management of pancreatic cancer.Some studies have shown that the mitochondrial uncoupling protein 2(UCP2) is over-expressed in pancreatic cancer as compared to adjacent normal tissues.In addition,recent discoveries established a key role of UCP2 in protecting cancer cells from an excessive production of mitochondrial superoxide ions and in the promotion of cancer cell metabolic reprogramming,including aerobic glycolysis stimulation,promotion of cancer progression.These observations together with the demonstration that UCP2 repression can synergize with standard chemotherapy to inhibit pancreatic cancer cell growth provide the molecular rationale to consider UCP2 as a potential therapeutic target for pancreatic cancer.In this editorial,recent advances describing the relationship between cancer development and mitochondrial UCP2 activity are critically provided. | Massimo Donadelli Ilaria Dando Elisa Dalla Pozza Marta Palmieri | 2015 | World Journal of Gastroenterology2015，21，11： | 9 |
| 3 | 基于微观力学模型的沥青混合料水损坏研究显示文摘水-荷载的耦合作用是沥青路面早期破坏的主要原因。该文提出了沥青混合料水损坏的微观力学模型,该模型可以用来量化分析在水-荷载的耦合作用下沥青混合料的损伤过程。同时,考虑到材料的力学性能是含水量的函数,利用内聚力模型对集料-沥青结合料间界面的粘结破坏进行了模拟,并通过沥青混合料内部应力、应变的变化研究了集料-沥青界面间裂缝发生的位置、时间和裂缝扩展过程。结果证明:微观力学模型可以用来揭示沥青混合料水损坏机理,并对连续损伤模型的建立具有一定指导意义。 | 张静 马士宾 魏连雨 孙敬福 Silvia Caro Eyad Masad Amit Bhasin Dallas Little | 2015 | 中外公路2015，35，6： | 8 |
| 4 | Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine显示文摘Erysiphe necator is the causal agent of powdery mildew(PM),one of the most destructive diseases of grapevine.PM is controlled by sulfur-based and synthetic fungicides,which every year are dispersed into the environment.This is why PM-resistant varieties should become a priority for sustainable grapevine and wine production.PM resistance can be achieved in other crops by knocking out susceptibility S-genes,such as those residing at genetic loci known as MLO(Mildew Locus O).All MLO S-genes of dicots belong to the phylogenetic clade V,including grapevine genes VvMLO7,11 and 13,which are upregulated during PM infection,and VvMLO6,which is not upregulated.Before adopting a gene-editing approach to knockout candidate S-genes,the evidence that loss of function of MLO genes can reduce PM susceptibility is necessary.This paper reports the knockdown through RNA interference of VvMLO6,7,11 and 13.The knockdown of VvMLO6,11 and 13 did not decrease PM severity,whereas the knockdown of VvMLO7 in combination with VvMLO6 and VvMLO11 reduced PM severity up to 77%.The knockdown of VvMLO7 and VvMLO6 seemed to be important for PM resistance,whereas a role for VvMLO11 does not seem likely.Cell wall appositions(papillae)were present in both resistant and susceptible lines in response to PM attack.Thirteen genes involved in defense were less upregulated in infected mlo plants,highlighting the early mlo-dependent disruption of PM invasion. | Stefano Pessina Luisa Lenzi Michele Perazzolli Manuela Campa Lorenza Dalla Costa Simona Urso Giampiero Valè Francesco Salamini Riccardo Velasco Mickael Malnoy | 2016 | Horticulture Research2016，3，1： | 7 |
| 5 | Neoadjuvant therapy in the treatment of hilar cholangiocarcinoma:Review of the literature显示文摘Cholangiocarcinoma(CCA)is a malignant tumor of the biliary system and includes,according to the anatomical classification,intra hepatic CCA(iCCA),hilar CCA(hCCA)and distal CCA(dCCA).Hilar CCA is the most challenging type in terms of diagnosis,treatment and prognosis.Surgery is the only treatment possibly providing long-term survival,but only few patients are considered resectable at the time of diagnosis.In fact,tumor’s extension to segmentary or subsegmentary biliary ducts,along with large lymph node involvement or intrahepatic metastases,precludes the surgical approach.To achieve R0 margins is mandatory for the disease-free survival and overall survival.In case of unresectable locally advanced hCCA,radiochemotherapy(RCT)as neoadjuvant treatment demonstrated to be a therapeutic option before either hepatic resection or liver transplantation.Before liver surgery,RCT is believed to enhance the R0 margins rate.For patients meeting the Mayo Clinic criteria,RCT prior to orthotopic liver transplant(OLT)has proved to produce acceptable 5-years survivals.In this review,we analyze the current role of neoadjuvant RCT before resection as well as before OLT. | Fabio Frosio Federico Mocchegiani Grazia Conte Enrico Dalla Bona ANDrea Vecchi Daniele Nicolini Marco Vivarelli | 2019 | World Journal of Gastrointestinal Surgery2019，11，6： | 7 |
| 6 | Herbicide resistance: Development of wheat production systems and current status of resistant weeds in wheat cropping systems显示文摘Herbicide resistance in crops has extended the scope of herbicide applications to control weeds. The introduction of herbicide resistant crops resulted in a major shift in the way that herbicides are used in many crops, but not necessarily increased the prevalence of herbicide use, especially in wheat. Wheat is one of the most widely grown crops in the world and currently only two major herbicide-resistant wheat groups have been commercialized to manage weeds in a cost-effective manner. However, sustainable wheat production is threatened by the expanding occurrence of herbicide-resistant weed populations with limited efforts to discover new herbicide molecules. Selective control of certain problematic weeds in wheat was impossible until development and introduction of the technologies, Clearfield and Co AXium Production Systems. However, the current limitations of reliance on specific herbicides and evolution of resistant weeds mandate precautions and considerations when using these systems to prevent the loss of existing herbicide resources and continue sustainable wheat production. The focus of this review is to provide an overview of natural pre-existing herbicide resistance and development of herbicide-resistant technologies in wheat. The mechanisms of resistance to herbicides in wheat as well as the weed populations in wheat cropping systems, and implications for weed management are discussed. | Sridevi Nakka Mithila Jugulam Dallas Peterson Mohammad Asif | 2019 | The Crop Journal2019，7，6： | 6 |
| 7 | COVID-19 Mortality and Vaccine Coverage——Hong Kong Special Administrative Region,China,January 6,2022-March 21,2022显示文摘Summary What is already known about this topic?COVID-19 vaccines are important tools to protect populations from severe disease and death.What is added by this report?Among persons aged≥60 years in Hong Kong,49%,had received≥2 doses of a COVID-19 vaccine,and vaccination coverage declined with age.During January-March 2022,reported COVID-19-associated deaths rose rapidly in Hong Kong.Among these deaths,96%occurred in persons aged≥60 years;within this age group,the risk for death was 20 times lower among those who were fully vaccinated compared with those who were unvaccinated. | Dallas J.Smith Avi J.Hakim Gabriel M.Leung Wenbo Xu WWilliam Schluter Ryan T.Novak Barbara Marston Bradley S.Hersh | 2022 | China CDC weekly2022，4，14： | 6 |
| 8 | pregnane X receptor and constitutive androstane receptor modulate differently CYp3A-mediated metabolism in earlyand late-stage cholestasis显示文摘AIM To ascertain whether cholestasis affects the expression of two CYP3 A isoforms(CYP3 A1 and CYP3 A2) and of pregnane X receptor(PXR) and constitutive androstane receptor(CAR).METHODS Cholestasis was induced by bile duct ligation in 16 male Wistar rats; whereas 8 sham-operated rats were used as controls. Severity of cholestasis was assessed on histological examination of liver sections, and serum concentrations of albumin, AST, ALT, GGT, ALPK and bilirubin. Gene and protein expressions of PXR, CAR, CYP3 A1 and CYP3 A2 were assessed by means of q RT-PCR and Western blot, respectively. Alterations in CYP3 A activity were measured by calculating the kinetic parameters of 4-OH and 1'-OH-midazolam hydroxylation, marker reactions for CYP3 A enzymes.RESULTS The m RNA and protein expression of CYP3 A1 increased significantly in mild cholestasis(P < 0.01). At variance, m RNA and protein expression of CYP3 A2 didn't change in mild cholestasis, whereas the expression and activity of both CYP3 A1 and CYP3 A2 decreased dramatically when cholestasis became severe. Consistently with these observations, the nuclear expression of both PXR and CAR, which was measured because they both translocate into the cell nucleus after their activation, virtually disappeared in the late stage of cholestatic injury, after an initial increase. These results indicate that early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently, probably as consequence of the different activation of PXR and CAR.CONCLUSION Early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently. PXR and CAR might be targeted therapeutically to promote CYP3 Amediated liver detoxification. | Daniela Gabbia Arianna Dalla Pozza Laura Albertoni Roberta Lazzari Giorgia Zigiotto Maria Carrara Vincenzo Baldo Tatjana Baldovin Annarosa Floreani Sara De Martin | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 9 | Scientific development of smart farming technologies and their application in Brazil显示文摘Smart farming(SF)involves the incorporation of information and communication technologies into machinery,equipment,and sensors for use in agricultural production systems.New technologies such as the internet of things and cloud computing are expected to advance this development,introducing more robots and artificial intelligence into farming.Therefore,the aims of this paper are twofold:(i)to characterize the scientific knowledge about SF that is available in the worldwide scientific literature based on the main factors of development by country and over time and(ii)to describe current SF prospects in Brazil from the perspective of experts in this field.The research involved conducting semi-structured interviews with market and researcher experts in Brazil and using a bibliometric survey by means of data mining software.Integration between the different available systems on the market was identified as one of the main limiting factors to SF evolution.Another limiting factor is the education,ability,and skills of farmers to understand and handle SF tools.These limitations revealed a market opportunity for enterprises to explore and help solve these problems,and science can contribute to this process.China,the United States,South Korea,Germany,and Japan contribute the largest number of scientific studies to the field.Countries that invest more in R&D generate the most publications;this could indicate which countries will be leaders in smart farming.The use of both research methods in a complementary manner allowed to understand how science frame the SF and the mains barriers to adopt it in Brazil. | Dieisson Pivoto Paulo Dabdab Waquil Edson Talamini Caroline Pauletto Spanhol Finocchio Vitor Francisco Dalla Corte Giana de Vargas Mores | 2018 | Information Processing in Agriculture2018，5，1： | 5 |
| 10 | The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells显示文摘 | Alice Cristina RODRIGUES Rui CURI Fabiana Dalla Vecchia GENVIGIR Mario Hiroyuki HIRATA Rosario Dominguez Crespo HIRATA | 2009 | Acta Pharmacologica Sinica2009，30，7： | 4 |
| 11 | Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial显示文摘 | Guglielmo Ronco Paolo Giorgi-Rossi Francesca Carozzi Massimo Confortini Paolo Dalla Palma Annarosa Del Mistro Bruno Ghiringhello Salvatore Girlando Anna Gillio-Tos Laura De Marco Carlo Naldoni Paola Pierotti Raffaella Rizzolo Patrizia Schincaglia Manuel Z | 2010 | Lancet Oncology2010，，3： | 3 |
| 12 | Use of a Laser/TIG Combination for Surface Modification of Ti-6Al-4V Alloy显示文摘The surface modification of materials such as Ti-6Al-4V is necessary to improve their wear resistant properties for use in tribological applications. In this paper it is shown that a laser with low power and tungsten inert gas (TIG) can be combined together for surface modification of Ti-6Al-4V alloy, and when performed in a controlled atmosphere of pure nitrogen or a mixture of nitrogen and argon, can produce a wear-resistant surface alloy. Compared with laser processing, a cheaper surface modification process has been developed involving a shorter processing time, which is free of stringent requirements such as a vacuum system. | M.Labudovic and R.Kovacevic Southern Methodist University, Dept. of Mechanical Engineering, Dallas, Texas, U.S.A. | 2001 | Journal of Materials Science & Technology2001，17，2： | 2 |
| 13 | Non-contact mechanical and chemical analysis of single living cells by microspectroscopic techniques显示文摘Innovative label-free microspectroscopy,which can simultaneously collect Brillouin and Raman signals,is used to characterize the viscoelastic properties and chemical composition of living cells with sub-micrometric resolution.The unprecedented statistical accuracy of the data combined with the high-frequency resolution and the high contrast of the recently built experimental setup permits the study of single living cells immersed in their buffer solution by contactless measurements.The Brillouin signal is deconvoluted in the buffer and the cell components,thereby revealing the mechanical heterogeneity inside the cell.In particular,a 20%increase is observed in the elastic modulus passing from the plasmatic membrane to the nucleus as distinguished by comparison with the Raman spectroscopic marker.Brillouin line shape analysis is even more relevant for the comparison of cells under physiological and pathological conditions.Following oncogene expression,cells show an overall reduction in the elastic modulus(15%)and apparent viscosity(50%).In a proof-of-principle experiment,the ability of this spectroscopic technique to characterize subcellular compartments and distinguish cell status was successfully tested.The results strongly support the future application of this technique for fundamental issues in the biomedical field. | Sara Mattana Maurizio Mattarelli Lorena Urbanelli Krizia Sagini Carla Emiliani Mauro Dalla Serra Daniele Fioretto Silvia Caponi | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 14 | Development of a sensitive and quantitative diagnostic assay for fish nervous necrosis virus based on two-target real-time PCR显示文摘 | L. Dalla Valle V. Toffolo M. Lamprecht C. Maltese G. Bovo P. Belvedere L. Colombo | 2005 | Veterinary Microbiology2005，，： | 2 |
| 15 | Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis显示文摘 | Lynne E. Vinall Marie King Marco Novelli Carole A. Green Geoff Daniels John Hilkens Martin Sarner Dallas M. Swallow | 2002 | Gastroenterology2002，，1： | 2 |
| 16 | UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells显示文摘 | Ilaria Dando Claudia Fiorini Elisa Dalla Pozza Chiara Padroni Chiara Costanzo Marta Palmieri Massimo Donadelli | 2013 | BBA - Molecular Cell Research2013，，3： | 2 |
| 17 | The maximum reservoir capacity of soils for persistent organic pollutants: implication for global cycling 显示文摘 | Dalla Valle M Jurado E Dachs J | 2005 | Environmental Pollution2005，134，1： | 1 |
| 18 | Acute - phase markers of inflammation and glomerular structure in patients with type 2 diabetes 显示文摘 | Dalla Vestra M Mussap M Gallina P | 2005 | J Am Soc Nephrol2005，16，1： | 1 |
| 19 | Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabtes显示文摘 | Dalla Vestra M Masiero A Roiter AM | 2003 | Diabetes2003，52，4： | 1 |
| 20 | Is podocyte injury relevantin diabetic nephropathy? Studies in patients with type 2 diabetes显示文摘 | DALLA M MASIERO A ROITER AM | 2003 | Diabetes2003，52，： | 1 |
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