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| 1 | Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach显示文摘Lingguizhugan Decoction(LGZG)has been investigated in basic studies,with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease(NAFLD).This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting.A randomized,double-blinded,placebo-controlled trial was performed.A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG(two groups:standard dose and low dose)or placebo for 12 weeks on the basis of lifestyle modifications.The primary efficacy variable was homeostasis model assessment of insulin resistance(HOMA-IR).Analyses were performed in two populations in accordance with body mass index(BMI;overweight/obese,BMI 24 kg/m^(2);lean,BMI<24 kg/m^(2)).For overweight/obese participants,low-dose LGZG significantly decreased their HOMA-IR level compared with placebo(0.19(1.47)versus 0.08(1.99),P=0.038).For lean subjects,neither dose of LGZG showed a superior effect compared with placebo.Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A(PPP1R3A)and autophagy related 3(ATG3)significantly increased after LGZG intervention in overweight/obese population.Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3.Lean subjects may not be a targeted population for LGZG. | Liang Dai Jingjuan Xu Baocheng Liu Yanqi Dang Ruirui Wang Lijie Zhuang Dong Li Lulu Jiao Jianying Wang Lei Zhang Linda LDZhong Wenjun Zhou Guang Ji | 2022 | Frontiers of Medicine2022，16，5： | 7 |
| 2 | Three Cases of COVID-19 Variant Delta With and Without Vaccination——Chengdu City,Sichuan Province,April-May,2021显示文摘On April 26,2021,a 33-year-old male Chinese sailor returning from India via Kathmandu,Nepal,tested positive for the coronavirus disease 2019(COVID-19)by Chengdu Customs and was confirmed positive by Chengdu CDC(Case A).On May 2,2021,a housewife in the same flight tested positive for COVID-19 by Pengzhou CDC in Sichuan Province during her quarantine period and was confirmed positive by Chengdu CDC the next day(Case B). | Heng Chen Yi Mao Zhenhua Duan Liang Wang Yue Cheng Yingxue Dai Haixia Luo Wenjun Xie Shuangfeng Fan Yuzhen Zhou Jingpei Xu Lan Feng Liwen Hu Zhu Liu Xian Liang Liangshuang Jiang Xiaoli Tuo | 2021 | China CDC weekly2021，3，25： | 5 |
| 3 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 4 | A graphene rheostat for highly durable and stretchable strain sensor显示文摘Strain sensors for human health monitoring are of paramount importance in wearable medical diagnostics and personal health monitoring.Despite extensive studies,strain sensors with both high durability and stretchability are still desired,particularly with the stability for different environmental conditions.Here,we report a series of strain sensors possessing the graphene network with a high density of intermittent physical interconnections,which produces the relative resistance change by varying the overlap area between the neighboring graphene sheets under stretching and releasing,analogous to the slide rheostat working in electronics.Our in-situ transmission electron microscope observation reveals the full recoverability of the structure from large deformation upon unloading for ensuring the exceptional cycle stability of our material on monitoring full-range body movements.The stable response is also demonstrated over wide temperature range and frequency range,because the peculiar dynamic structure can be maintained through the self-adjustment to the thermal expansion of the bulk material.Based on the working mechanism of graphene“slide rheostat,”the sensing properties of the strain sensor are tailored by tuning the graphene network structure with different mass densities using different concentrations of graphene oxide dispersion,while the stretchability and sensitivity can be separately optimized for different application requirements. | Jing Ren Wenjun Zhang Yubo Wang Yaxiong Wang Jun Zhou Liming Dai Ming Xu | 2019 | InfoMat2019，1，3： | 4 |
| 5 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 6 | Battlefield dynamic scanning and staring imaging system based on fast steering mirror显示文摘This paper presents the design of an experimental battlefield dynamic scanning and staring imaging system based on a fast steering mirror(FSM), which is capable of real-time monitoring of hot targets and wide-area reconnaissance of hot regions. First,the working principle and working sequence of the FSM are briefly analyzed. The mathematical model of the FSM system is built by modeling its dynamic and electrical properties, and the rationality of the model is validated by means of model identification. Second,the influence of external sources of disturbance such as the carrier and moment on the control precision of the FSM is effectively suppressed by the jointly controlling of proportional integral(PI)and disturbance observer(DOB), thus realizing a high precision and strong robustness control of the FSM system. Then, this paper designs an experimental prototype and introduces a special optical structure to enable the infrared camera to share the FSM with the visible light camera. Finally, the influence of the velocity difference between the mirror of the FSM and the rotating platform on the imaging quality of the system is experimentally analyzed by using the image sharpness evaluation method based on point sharpness. A good dynamic scanning and staring imaging result is achieved when the velocity of these two components correspond. | CHANG Tianqing WANG Quandong ZHANG Lei HAO Na DAI Wenjun | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 3 |
| 7 | Semantic information processing in industrial networks显示文摘The industrial Internet of things(industrial IoT, IIoT) aims at connecting everything, which poses severe challenges to existing wireless communication. To handle the demand for massive access in future industrial networks, semantic information processing is integrated into communication systems so as to improve the effectiveness and efficiency of data transmission. The semantic paradigm is particularly suitable for the purpose-oriented information exchanging scheme in industrial networks. To illustrate its applicability, typical industrial data are investigated, i.e., time series and images. Simulation results demonstrate the superiority of semantic information processing, which achieves a better rate-utility tradeoff than conventional signal processing. | Yao Shengshi Wang Sixian Dai Jincheng Niu Kai Xu Wenjun Zhang Ping | 2022 | The Journal of China Universities of Posts and Telecommunications2022，29，1： | 2 |
| 8 | Study on Cryopreservation of Porphyra yezoensis Conchocelis显示文摘Cryopreservation of Porphyra yezoensis conchocelis was conducted with cryoprotectants and a proposed pretreatment procedure and thawing methods explored. Six cryoprotectants combined by DMSO with ethylene glycol(EG),propylene glycol(PEG),sorbitol and sucrose were developed. The effect of prefreezing at - 40℃ or -20℃ for different time durations was compared and the thawing methods were screened. It was shown that the cryoprotectant including 10% DMSO with 0.5 molL-1 sorbitol exhib-ited the optimal effect. The ideal pretreatment was that conchocelis segments were stayed for 20 min at - 40℃ before stored in liquid nitrogen,and 40℃ water bath was proper for quick thawing. The highest recovery rate of cryopreserved P. yezoensis conchocelis reached 89.41%. | ZHOU Wenjun LI Yun DAI Jixun | 2007 | Journal of Ocean University of China2007，6，3： | 2 |
| 9 | Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules. | Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao | 2022 | Zoological Systematics2022，47，3： | 2 |
| 10 | Boron difluoride formazanate dye for high-efficiency NIR-Ⅱ fluorescence imaging-guided cancer photothermal therapy显示文摘The small molecular second near-infrared(NIR-Ⅱ, 1000–1700 nm) dye-based nanotheranostics can concurrently combine deep-tissue photodiagnosis with in situ phototherapy, which occupies a vital position in the early detection and precise treatment of tumors. However, the development of small molecular NIR-Ⅱ dyes is still challenging due to the limited electron acceptors and cumbersome synthetic routes.Herein, we report a novel molecular electron acceptor, boron difluoride formazanate(BDF). Based on BDF, a new small molecular NIR-Ⅱ dye BDF1005 is designed and synthesized with strong NIR-I absorption at 768 nm and bright NIR-Ⅱ peak emission at 1034 nm. In vitro and in vivo experiments demonstrate that BDF1005-based nanotheranostics can be applied for NIR-Ⅱ fluorescence imaging-guided photothermal therapy of 4T1 tumor-bearing mice. Under 808 nm laser irradiation, tumor growth can be effectively inhibited. This work opens up a new road for the exploitation of NIR-Ⅱ small molecular dyes for cancer phototheranostics. | Hanming Dai Zijin Cheng Tian Zhang Weili Wang Jinjun Shao Wenjun Wang Yongxiang Zhao Xiaochen Dong Liping Zhong | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 11 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 12 | Influence of functionalized polyolefin on interfacial adhesion of glass fiber reinforced polypropylene显示文摘 | Zhou Xiaodong Dai Gance Guo Wenjun | 2000 | J Appl Polym Sci2000，76，8： | 1 |
| 13 | Hydrogen-Bonded Dopant-Free Hole Transport Material Enables Efficient and Stable Inverted Perovskite Solar Cells显示文摘Although many dopant-free hole transport materials(HTMs)for perovskite solar cells(PSCs)have been investigated in the literature,novel and useful molecular designs for high-performance HTMs are still needed.In this work,a hydrogen-bonding association system(NH⋯CO)between amide and carbonyl is introduced into the pure HTM layer. | Rui Li Chongwen Li Maning Liu Paola Vivo Meng Zheng Zhicheng Dai Jingbo Zhan Benlin He Haiyan Li Wenjun Yang Zhongmin Zhou Haichang Zhang | 2022 | CCS Chemistry2022，4，9： | 1 |
| 14 | Transformation of inert PbSO4 deposit on the neg- ative electrode of a lead-acid battery into its active state 显示文摘 | Zhang Bo Zhong Juhua Li Wenjun Dai Zhongyi Zhang Bo Cheng Zhenmin | 2010 | Jour- nal of Power Sources2010，195，13： | 1 |
| 15 | DTMB application in shanghai SFN transmission network显示文摘 | GUAN Yunfeng DAI Yihe ZHANG Wenjun | 2013 | IEEE Transactions on Broadcasting2013，59，1： | 1 |
| 16 | Application of Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) in Screening of High Risk Children with Inherited Metabolic Diseases in Northern China显示文摘 | Wenjun Tu Xiaotao Song Fang Dai James Jian Ho | 2010 | Journal of Pediatric Endocrinology and Metabolism2010，，12： | 1 |
| 17 | Influence of Functionalized Polylefin on Interracial Adhesion of Glass Fiber Reinforced Polypropylene显示文摘 | Xiaodong Zhou Gance Dai Wenjun Guo Qunfang Lin | 2000 | Journal of Applied Polymer Science2000，76，8： | 1 |
| 18 | Maternal genetic structure of a neolithic population of the Yangshao culture显示文摘The Yangshao culture is one of the most influential Neolithic cultures in East Asia.The populations associated with the Yangshao culture were widely distributed along the Yellow River basin and were suggested to play a profound role in the present-day East Asians.To date,the population of the Yangshao culture is largely investigated through archaeological studies. | Bo Miao Yichen Liu Wanfa Gu Qingli Wei Qian Wu Wenjun Wang Ming Zhang Manyu Ding Tianyi Wang Juncen Liu Feng Liu Peng Cao Qingyan Dai Ruowei Yang Xiaotian Feng Wanjing Ping Weihong Hou Haibing Yuan Qiaomei Fu | 2021 | Journal of Genetics and Genomics2021，48，8： | 0 |
| 19 | Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique显示文摘Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic' that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19. | Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang | 2023 | National Science Review2023，10，4： | 0 |
| 20 | Phytoplankton Structure and Evaluation of Water Quality in Spring in the Moats of Dinghai District,Zhoushan City显示文摘Phytoplankton structure in spring in the moats of Dinghai District,Zhoushan City was investigated in April 2016. Firstly,the species composition and dominant species of phytoplankton were analyzed,and then the water quality of the moats was evaluated by cell density,water-quality indicator species,biodiversity index method,and saprobic index method. The results show that there were 114 species of phytoplankton in the moats of Dinghai District in spring,belonging to 70 genera,38 families,and 7 phyla,of which Bacillarophyta,Chlorophyta and Cyanophyta were dominant; the main dominant species were Synedra acus,Aphanizomenon flosaquae,Microcytis flos-aquae,etc. The cell density of phytoplankton in the moats ranged from 1.07 million to 13.7 million cells/L. Shannon-Wiener diversity index,Margalef richness index,Pielou evenness index,and saprobic index averaged 0.93,2.53,0.12,and 2.61 respectively. On the whole,river water in the moats of Dinghai District was polluted seriously,but there was no obvious difference between the four rivers in water pollution. | Wu Yanmei Wu Jiameng Hu Fanglu Dai Jiawei Zhang Shaoqiu Zhang Wenjun Zhu Mingdong Xu Nana | 2016 | Meteorological and Environmental Research2016，7，6： | 0 |
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