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| 1 | 西藏高原上地幔的精细结构与构造——地震层析成像给出的启示显示文摘利用布置在亚东—格尔木的 1 6 4个流动地震台站记录的 92 6个远震事件的 2 4 2 4 1条射线 ,进行远震P波层析成像处理 ,高分辨率的西藏高原上地幔的速度结构图 ,显示了印度巨厚地幔岩石圈在向高原之下推进的过程中 ,在高喜马拉雅之下拆分成上、下两层 ,这是发生的第一次拆沉 .下层从高喜马拉雅以下约以 2 2°的角度向高原北部插入到 35 0km深 ;而其上层则向北伸展直到雁石坪 ,并构成了高原薄的地幔岩石圈 .在雁石坪北 (33.7°N) ,当其与亚洲大陆岩石圈地幔相遇后发生断离并下沉 .再次证实了五道梁 (35 .2 7°N)深部低速体的存在 ,本区内地壳内低速物质可能与上述运动有联系 。 | 赵文津 薛光琦 吴珍汉 赵逊 刘葵 史大年 J.Mechie D.Nelson L.Brown T.Hearn | 2004 | 地球物理学报2004，47，3： | 39 |
| 2 | Patient-derived orthotopic xenograft models for cancer of unknown primary precisely distinguish chemotherapy,and tumor-targeting S.typhimurium A1-R is superior to first-line chemotherapy显示文摘Cancer of unknown primary(CUP)is a recalcitrant disease with poor prognosis because it lacks standard first-line therapy.CUP consists of diverse malignancy groups,making personalized precision therapy essential.The present study aimed to identify an effective therapy for a CUP patient using a patient-derived orthotopic xenograft(PDOX)model.This paper reports the usefulness of the PDOX model to precisely identify effective and ineffective chemotherapy and to compare the efficacy of S.typhimurium A1-R with first-line chemotherapy using the CUP PDOX model.The present study is the first to use a CUP PDOX model,which was able to precisely distinguish the chemotherapeutic course.We found that a carboplatinum(CAR)-based regimen was effective for this CUP patient.We also demonstrated that S.typhimurium A1-R was more effective against the CUP tumor than first-line chemotherapy.Our results indicate that S.typhimurium A1-R has clinical potential for CUP,a resistant disease that requires effective therapy. | Kentaro Miyake Tasuku Kiyuna Masuyo Miyake Kei Kawaguchi Sang Nam Yoon Zhiying Zhang Kentaro Igarashi Sahar Razmjooei Sintawat Wangsiricharoen Takashi Murakami Yunfeng Li Scott D.Nelson Tara A.Russell Arun S.Singh Yukihiko Hiroshima Masashi Momiyama Ryusei Matsuyama Takashi Chishima Shree Ram Singh Itaru Endo Fritz C.Eilber Robert M.Hoffman | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 2 |
| 3 | Mechanical properties and in vitro degradation of bioresorbable fibers and expandable fiber‐based stents显示文摘 | MeitalZilberman Kevin D.Nelson Robert C.Eberhart | 2005 | J Biomed Mater Res2005，，2： | 1 |
| 4 | On the generalization of relative clause instruction in the acquisition of English as a second language显示文摘 | Eckman F L.Bell D.Nelson | | 0，，： | 1 |
| 5 | Maximum Likelihood Methods for Models of Markets in Disequilibrium显示文摘 | G.S.Maddala Forrest D.Nelson | | 0，，06： | 1 |
| 6 | Sclerotinia sclerotiorum (Lib.) de Bary: biology and molecular traits of a cosmopolitan pathogen显示文摘 | MELVIN D.BOLTON BART P. H. J.THOMMA BERLIN D.NELSON | 2005 | Molecular Plant Pathology2005，，1： | 1 |
| 7 | General noise process in hybrid infrared focal plane arrays显示文摘 | Mark D.Nelson Jerris F.Johnson Terrence S.Lomheim | | 0，，11： | 1 |
| 8 | Evading the host response:Staphylococcus“hiding”in cortical bone canalicular system causes increased bacterial burden显示文摘Extremity reconstruction surgery is increasingly performed rather than amputation for patients with large-segment pathologic bone loss.Debate persists as to the optimal void filler for this“limb salvage”surgery,whether metal or allograft bone.Clinicians focus on optimizing important functional gains for patients,and the risk of devastating implant infection has been thought to be similar regardless of implant material.Recent insights into infection pathophysiology are challenging this equipoise,however,with both basic science data suggesting a novel mechanism of infection of Staphylococcus aureus(the most common infecting agent)into the host lacunar–canaliculi network,and also clinical data revealing a higher rate of infection of allograft over metal.The current translational study was therefore developed to bridge the gap between these insights in a longitudinal murine model of infection of allograft bone and metal.Real-time Staphylococci infection characteristics were quantified in cortical bone vs metal,and both microarchitecture of host implant and presence of host immune response were assessed.An orders-of-magnitude higher bacterial burden was established in cortical allograft bone over both metal and cancellous bone.The establishment of immune-evading microabscesses was confirmed in both cortical allograft haversian canal and the submicron canaliculi network in an additional model of mouse femur bone infection.These study results reveal a mechanism by which Staphylococci evasion of host immunity is possible,contributing to elevated risks of infection in cortical bone.The presence of this local infection reservoir imparts massive clinical implications that may alter the current paradigm of osteomyelitis and bulk allograft infection treatment. | Stephen D.Zoller Vishal Hegde Zachary D.C.Burke Howard Y.Park Chad R.Ishmael Gideon W.Blumstein William Sheppard Christopher Hamad Amanda H.Loftin Daniel O.Johansen Ryan A.Smith Marina M.Sprague Kellyn R.Hori Samuel J.Clarkson Rachel Borthwell Scott I.Simon Jeff F.Miller Scott D.Nelson Nicholas M.Bernthal | 2020 | Bone Research2020，8，4： | 0 |
| 9 | Streamlining the preparation of “endotoxin-free” ClearColi cell extract with autoinduction media for cell-free protein synthesis of the therapeutic protein crisantaspase显示文摘An“endotoxin-free”E.coli-based cell-free protein synthesis system has been reported to produce therapeutic proteins rapidly and on-demand.However,preparation of the most complex CFPS reagent–the cell extract–remains time-consuming and labor-intensive because of the relatively slow growth kinetics of the endotoxin-free ClearColiTMBL21(DE3)strain.Here we report a streamlined procedure for preparing E.coli cell extract from ClearColi™using auto-induction media.In this work,the term auto-induction describes cell culture media which eliminates the need for manual induction of protein expression.Culturing Clearcoli™cells in autoinduction media significantly reduces the hands-on time required during extract preparation,and the resulting“endotoxinfree”cell extract maintained the same cell-free protein synthesis capability as extract produced with traditional induction as demonstrated by the high-yield expression of crisantaspase,an FDA approved leukemia therapeutic.It is anticipated that this work will lower the barrier for researchers to enter the field and use this technology as the method to produce endotoxin-free E.coli-based extract for CFPS. | J.Porter Hunt Emily Long Zhao Mehran Soltani Madison Frei J.Andrew D.Nelson Bradley C.Bundy | 2019 | Synthetic and Systems Biotechnology2019，4，4： | 0 |
| 10 | Addressing nonresponse bias in forest inventory change estimation using response homogeneity classifications显示文摘Estimating amounts of change in forest resources over time is a key function of most national forest inventories(NFI). As this information is used broadly for many management and policy purposes, it is imperative that accurate estimations are made from the survey sample. Robust sampling designs are often used to help ensure representation of the population, but often the full sample is unrealized due to hazardous conditions or possibly lack of land access permission. Potentially, bias may be imparted to the sample if the nonresponse is nonrandom with respect to forest characteristics, which becomes more difficult to assess for change estimation methods that require measurements of the same sample plots at two points in time, i.e., remeasurement. To examine potential nonresponse bias in change estimates, two synthetic populations were constructed: 1) a typical NFI population consisting of both forest and nonforest plots, and 2) a population that mimics a large catastrophic disturbance event within a forested population. Comparisons of estimates under various nonresponse scenarios were made using a standard implementation of post-stratified estimation as well as an alternative approach that groups plots having similar response probabilities(response homogeneity). When using the post-stratified estimators, the amount of change was overestimated for the NFI population and was underestimated for the disturbance population, whereas the response homogeneity approach produced nearly unbiased estimates under the assumption of equal response probability within groups. These outcomes suggest that formal strategies may be needed to obtain accurate change estimates in the presence of nonrandom nonresponse. | James A.Westfall Mark D.Nelson | 2023 | Forest Ecosystems2023，10，1： | 0 |
| 11 | Are EPB41 and alpha-synuclein diagnostic biomarkers of sport-related concussion?Findings from the NCAA and Department of Defense CARE Consortium显示文摘Background:Current protein biomarkers are only moderately predictive at identifying individuals with mild traumatic brain injury or concussion.Therefore,more accurate diagnostic markers are needed for sport-related concussion.Methods:This was a multicenter,prospective,case-control study of athletes who provided blood samples and were diagnosed with a concussion or were a matched non-concussed control within the National Collegiate Athletic Association-Department of Defense Concussion Assessment,Research,and Education Consortium conducted between 2015 and 2019.The blood was collected within 48 h of injury to identify protein abnormalities at the acute and subacute timepoints.Athletes with concussion were divided into 6 h post-injury(0-6 h post-injury)and after 6 h postinjury(7-48 h post-injury)groups.We applied a highly multiplexed proteomic technique that used a DNA aptamers assay to target 1305proteins in plasma samples from athletes with and without sport-related concussion.Results:A total of 140 athletes with concussion(79.3%males;aged 18.71±1.10 years,mean±SD)and 21 non-concussed athletes(76.2%males;19.14±1.10 years)were included in this study.We identified 338 plasma proteins that significantly differed in abundance(319 upregulated and 19 downregulated)in concussed athletes compared to non-concussed athletes.The top 20 most differentially abundant proteins discriminated concussed athletes from non-concussed athletes with an area under the curve(AUC)of 0.954(95%confidence interval:0.922-0.986).Specifically,after 6 h of injury,the individual AUC of plasma erythrocyte membrane protein band 4.1(EPB41)and alpha-synuclein(SNCA)were 0.956 and 0.875,respectively.The combination of EPB41 and SNCA provided the best AUC(1.000),which suggests this combination of candidate plasma biomarkers is the best for diagnosing concussion in athletes after 6 h of injury.Conclusion:Our data suggest that proteomic profiling may provide novel diagnostic protein markers and that a combination of EPB41 and SNCA is the most predictive biomarker of concussion after 6 h of injury. | Rany Vorn Christina Devoto Timothy B.Meier Chen Lai Sijung Yun Steven P.Broglio Sara Mithani Thomas W.McAllister Christopher C.Giza Hyung-Suk Kim Daniel Huber Jaroslaw Harezlak Kenneth L.Cameron Gerald McGinty Jonathan Jackson Kevin M.Guskiewicz Jason P.Mihalik Alison Brooks Stefan Duma Steven Rowson Lindsay D.Nelson Paul Pasquina Michael A.McCrea Jessica M.Gill the CARE Consortium Investigators | 2023 | Journal of Sport and Health Science2023，12，3： | 0 |
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