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| 1 | Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight显示文摘Neuropeptide Y(NPY) is widely expressed in the central nervous system and influences many physiological processes.It is located within the rat quantitative trait locus(QTL) for alcohol preference on chromosome 4.Alcohol-nonpreferring(NP) rats consume very little alcohol,but have significantly higher NPY expression in the brain than alcohol-preferring(P) rats.We capitalized on this phenotypic difference by creating an Npy knockout(KO) rat using the inbred NP background to evaluate NPY effects on alcohol consumption.Zinc finger nuclease(ZNF) technology was applied,resulting in a 26-bp deletion in the Npy gene.RT-PCR,Western blotting and immunohistochemistry confirmed the absence of Npy mRNA and protein in KO rats.Alcohol consumption was increased in Npy^(+/-) but not Npy^(-/-) rats,while Npy^(-/-) rats displayed significantly lower body weight when compared to Npy^(+/+) rats.In whole brain tissue,expression levels of Npy-related and other alcohol-associated genes,Npy1 r,Npy2r,Npy5 r,Agrp,Mc3 r,Mc4r,Crh and CrMr,were significantly greater in Npy^(-/-) rats,whereas Pome and Crhr2 expressions were highest in Npy^(+/-) rats.These findings suggest that the NPY-system works in close coordination with the melanocortin(MC) and corticotropin-releasing hormone(CRH) systems to modulate alcohol intake and body weight. | Bin Qiu Richard L.Bell Yong Cao Lingling Zhang Robert B.Stewart Tamara Graves Lawrence Lumeng Weidong Yong Tiebing Liang | 2016 | Journal of Genetics and Genomics2016，43，7： | 2 |
| 2 | On the generalization of relative clause instruction in the acquisition of English as a second language显示文摘 | Eckman F L.Bell D.Nelson | | 0，，： | 1 |
| 3 | Views of Nature of Science Questionnaire:Toward Valid and Meaningful Assessment of Learners' Conceptions of Nature of Science显示文摘 | Norm G.Lederman 1 Fouad Abd-El-Khalick 2 Randy L.Bell 3 Rene'e S.Schwartz | | 0，，06： | 1 |
| 4 | An integrative bioinformatics pipeline shows that honeybee-associated microbiomes are driven primarily by pollen composition显示文摘The microbiomes associated with bee nests influence colony health through various mechanisms,although it is not yet clear how honeybee congeners differ in microbiome assembly processes,in particular the degrees to which floral visitations and the environment contribute to different aspects of diversity.We used DNA metabarcoding to sequence bacterial 16S rRNA from honey and stored pollen from nests of 4 honeybee species(Apis cerana,A.dorsata,A.florea,and A.laboriosa)sampled throughout Yunnan,China,a global biodiversity hotspot.We developed a computational pipeline integrating multiple databases for quantifying key facets of diversity,including compositional,taxonomic,phylogenetic,and functional ones.Further,we assessed candidate drivers of observed microbiome dissimilarity,particularly differences in floral visitations,habitat disturbance,and other key environmental variables.Analyses revealed that microbiome alpha diversity was broadly equivalent across the study sites and between bee species,apart from functional diversity which was very low in nests of the reclusive A.laboriosa.Turnover in microbiome composition across Yunnan was driven predominantly by pollen composition.Human disturbance negatively impacted both compositional and phylogenetic alpha diversity of nest microbiomes,but did not correlate with microbial turnover.We herein make progress in understanding microbiome diversity associated with key pollinators in a biodiversity hotspot,and provide a model for the use of a comprehensive informatics framework in assessing pattern and drivers of diversity,which enables the inclusion of explanatory variables both subtly and fundamentally different and enables elucidation of emergent or unexpected drivers. | Douglas Chesters Xiuwei Liu Karen L.Bell Michael C.Orr Tingting Xie Qingsong Zhou Chaodong Zhu | 2023 | Insect Science2023，30，2： | 0 |
| 5 | Fluctuating temperature modifies heat-mortality association around the globe显示文摘Studies have investigated the effects of heat and temperature variability(TV)on mortality.However,few assessed whether TV modifies the heat-mortality association.Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries.TV was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures. | Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh Mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana Madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda Michelle L.Bell Yuming Guo | 2022 | The Innovation2022，3，2： | 0 |
| 6 | 火炬松人工林土壤氮随定期燃烧的矿化和固定显示文摘为了火炬松(Pinus Taeda)林分中土壤氮的矿化和固定,在24年周期内每隔2年和4年燃烧一次,利用15N标记的硫酸氨添加剂对燃烧作用进行评价。在以O_e+O_a加上0—10cm矿质土的实验室培养控制中,净氮的矿化最大(210mgN/m^2);每隔2年燃烧处理一次,净氮的矿化中等(87mgN/m^2)每隔4年燃烧处理一次,净氮的矿化最小(78mgN/m^2)。森林腐殖质和矿质土经燃烧处理的C/N(碳/氮)比大于控制烧除的C/N此。所有抽样表明,添加的15N硫酸氨的固定率大于95%,每隔2年燃烧处理一次的样固定率大于每隔4年控制处理一次的样固定率。在相当缺氮的林地,两种燃烧方式看来是增加氮的固定率和减少氮的利用率。 | Rindy L.BELL DAN BINKLEY 邓健生 | 1991 | 中南林业调查规划1991，，2： | 0 |
| 7 | 美国空气中颗粒物成分暴露的环境不均等显示文摘摘要:[背景]越来越多的证据表明,直径≤2.5gm的细颗粒物(PM2.5),其化学成分不同毒性也不相同。不同的人群可能会受到不同成分的PM2.5暴露。[目的]调查是否不同种族/民族、年龄、社会经济地位(SES)的人群受到不同成分的PM2.5暴露。[方法]对美国215个人15/普查区域内PM2.5和14种PM2.5成分的长期暴露(2000-2006年)情况进行评估。 | Michelle L.Bell Keita Ebisu | 2013 | 环境与职业医学2013，30，3： | 0 |
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