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| 1 | 西藏班公湖-怒江缝合带——深部地球物理结构给出的启示显示文摘通过跨越缝合带的综合地球物理和地质调查研究,查明了地质上推测的“班公湖-怒江缝合带”的深部结构和构造,提出了下述观点现有资料尚不足以证明,“班公湖-怒江缝合带”是严格意义上的缝合带,而趋向表明是一个老的弧后拉张区,在后来的印度大陆与拉萨地块碰撞挤压过程中,先是沉积了巨厚的第三纪地层,仅在20Ma(?)以来才转变成挤压体制,形成多条逆冲断裂;纳木错-申扎逆冲的蛇绿岩片带代表着侏罗纪洋的主要缝合带位置,在其闭合过程中洋壳与陆壳一起向北发生俯冲,并形成班戈岩带所代表的岩浆弧,在岩浆弧后出现了拉张区;下地壳向北挤压增厚,物理性质不同的上、下地壳之间相互运动而形成了一条缓倾的剪切片理化带,南北长达300km,命名为主羌塘逆冲断裂带(MQT);并使班戈岩片整体向南逆推上去,致使地壳分层增厚;在拉张期伦坡拉小地块向下运动,20Ma以后转变成压缩体制后又开始向上逆推,再加上后期的剥蚀,致使班戈深成岩体出露于地表;唐古拉山、各拉丹冬等年轻的火山岩浆带与地表显示的构造活动无直接关系,推测应是地壳深层作用引起的构造岩浆活动的显示。 | 赵文津 刘葵 蒋忠惕 吴珍汉 赵逊 史大年 熊嘉育 J.Mechie L.Brown T.Hearn J.R.Guo Seth S.Haines | 2004 | 地质通报2004，23，7： | 37 |
| 2 | 西藏高原上地幔的精细结构与构造——地震层析成像给出的启示显示文摘利用布置在亚东—格尔木的 1 6 4个流动地震台站记录的 92 6个远震事件的 2 4 2 4 1条射线 ,进行远震P波层析成像处理 ,高分辨率的西藏高原上地幔的速度结构图 ,显示了印度巨厚地幔岩石圈在向高原之下推进的过程中 ,在高喜马拉雅之下拆分成上、下两层 ,这是发生的第一次拆沉 .下层从高喜马拉雅以下约以 2 2°的角度向高原北部插入到 35 0km深 ;而其上层则向北伸展直到雁石坪 ,并构成了高原薄的地幔岩石圈 .在雁石坪北 (33.7°N) ,当其与亚洲大陆岩石圈地幔相遇后发生断离并下沉 .再次证实了五道梁 (35 .2 7°N)深部低速体的存在 ,本区内地壳内低速物质可能与上述运动有联系 。 | 赵文津 薛光琦 吴珍汉 赵逊 刘葵 史大年 J.Mechie D.Nelson L.Brown T.Hearn | 2004 | 地球物理学报2004，47，3： | 39 |
| 3 | 中国北方城市肺癌与生活方式及环境污染的关系显示文摘在重工业集中的辽宁省几个城市开展研究,探讨生活方式和环境污染与肺癌高发的关系。在沈阳和鞍山进行的三项研究得出结论,吸烟仍是第一位病因,人口归因危险度(PAR)在男性为55%,女性为37%。室内空气污染指数与患病危险性呈显著线性相关,它的PAR在男性为13%,女性为17%。调整了以上因素后,室外大气污染仍起作用。病例可归因到职业暴露的大约在6~8%。其中主要危险的职业为冶金、化学制药、玻璃陶瓷、炼焦、冶炼、铸造、耐火砖制造、轧钢等。有尘作业的总的危险性(OR)为1.5(1.2~1.9)。OR与终生累积暴露量成正相关。Bap的累积暴露剂量也与OR呈正相关。水果和饮茶有保护作用。 | 徐肇翊 L.Brown 潘国伟 李光 冯毅平 刘铁夫 关德显 刘黎民 曹瑞民 盛家华 高更生 | 1996 | 肿瘤1996，16，4： | 20 |
| 4 | Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium显示文摘Orthopedic implants rely on facilitating a robust interaction between the implant material surface and the surrounding bone tissue.Ideally,the interface will encourage osseointegration with the host bone,resulting in strong fixation and implant stability.However,implant failure can occur due to the lack of integration with bone tissue or bacterial infection.The chosen material and surface topography of orthopedic implants are key factors that influence the early events following implantation and may ultimately define the success of a device.Early attachment,rapid migration and improved differentiation of stem cells to osteoblasts are necessary to populate the surface of biomedical implants,potentially preventing biofilm formation and implant-associated infection.This article explores these early stem cell specific events by seeding human mesenchymal stem cells(MSCs)on four clinically relevant materials:polyether ether ketone(PEEK),Ti6Al4V(smooth Ti),macro-micro rough Ti6Al4V(Endoskeleton®),and macro-micro-nano rough Ti6Al4V(nanoLOCK®).The results demonstrate the incorporation of a hierarchical macro-micro-nano roughness on titanium produces a stellate morphology typical of mature osteoblasts/osteocytes,rapid and random migration,and improved osteogenic differentiation in seeded MSCs.Literature suggests rapid coverage of a surface by stem cells coupled with stimulation of bone differentiation minimizes the opportunity for biofilm formation while increasing the rate of device integration with the surrounding bone tissue. | Emily G.Long Merve Buluk Michelle B.Gallagher Jennifer M.Schneider Justin L.Brown | 2019 | Bioactive Materials2019，4，1： | 8 |
| 5 | Design of multiple anti-windup loops for multiple activations显示文摘This paper considers anti-windup design for linear systems subject to actuator saturation.Three anti-windup gains are designed for activations immediately at the occurrence actuator saturation,after the saturation has reached a certain level and in anticipation of the occurrence of saturation,respectively.The design is based on the minimization of L 2 gain from the disturbance to the controlled output of the resulting closed-loop system.Traditional anti-windup scheme involves a single anti-windup loop for immediate activation.A recent innovation is to design a single anti-windup loop for delayed or anticipatory activation,as well as to design two anti-windup gains,one for immediate activation and one for delayed activation.Our design of three anti-windup gains for three different activations is shown through simulation to lead to significant further performance improvement over the previous activation schemes. | WU XiongJun 1,2 & LIN Zongli 3,1 1 Department of Automation,Shanghai Jiao Tong University,and Key Laboratory of System Control and Information Processing,Ministry of Education of China,Shanghai 200240,China 2 No.802 Institute of Shanghai Academy of Space Flight Technology,the Eighth Academy of China Aerospace Science and Technology Corporation,Shanghai 200090,China 3 Charles L.Brown Department of Electrical and Computer Engineering,University of Virginia,P.O.Box 400743,Charlottesville,VA 22904-4743,USA | 2012 | Science China(Information Sciences)2012，55，9： | 5 |
| 6 | 对领导人的挑战:创建患者安全的组织文化显示文摘创建患者安全的组织文化,是医疗机构领导人面临的挑战。创建患者安全的组织文化,需要领导人和所有员工的参与,需要进行持续的沟通,建立合理的组织架构,形成风险管理的机制。 | Fred L.Brown | 2007 | 中国医院2007，11，11： | 4 |
| 7 | ZmGns,a maize class I β-1,3-glucanase,is induced by biotic stresses and possesses strong antimicrobial activity显示文摘Plant b-1,3-glucanases are members of the pathogenesis-related protein 2(PR-2) family,which is one of the 17 PR protein families and plays important roles in biotic and abiotic stress responses.One of the differentially expressed proteins(spot 842) identified in a recent proteomic comparison between five pairs of closely related maize(Zea mays L.) lines differing in aflatoxin resistance was further investigated in the present study.Here,the corresponding cDNA was cloned from maize and designated as ZmGns.ZmGns encodes a protein of338 amino acids containing a potential signal peptide.The expression of Zm Gns was detectible in all tissues studied with the highest level in silks.ZmGns was significantly induced by biotic stresses including three bacteria and the fungus Aspergillus flavus.ZmGns was also induced by most abiotic stresses tested and growth hormones including salicylic acid.In vivo,ZmGns showed a significant inhibitory activity against thebacterial pathogen Pseudomonas syringae pv.tomato DC3000 and fungal pathogen Botrytis cinerea when it overexpressed in Arabidopsis.Its high level of expression in the silk tissue and its induced expression by phytohormone treatment,as well as by bacterial and fungal infections,suggest it plays a complex role in maize growth,development,and defense. | Yu-Rong Xie Yenjit Raruang Zhi-Yuan Chen Robert L.Brown Thomas E.Cleveland | 2015 | Journal of Integrative Plant Biology2015，57，3： | 3 |
| 8 | Managing contract performance: A transaction costs approach显示文摘 | Trevor L.Brown MatthewPotoski | 2003 | J Pol Anal Manage2003，，2： | 1 |
| 9 | Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses显示文摘 | Kelly L.Brown Grace F.T.Poon Darlene Birkenhead | | 0，，01： | 1 |
| 10 | Performance of automated slidemakers and stainers in a working laboratory environment – routine operation and quality control显示文摘 | E.SIMSON M. G.GASCON‐LEMA D. L.BROWN | 2010 | International Journal of Laboratory Hematology (p)2010，，1： | 1 |
| 11 | Cross‐Modal transfer of the conditioned eyeblink response during interstimulus interval discrimination training in young rats显示文摘 | Kevin L.Brown Mark E.Stanton | 2008 | Psychobiol2008，，7： | 1 |
| 12 | The protective effects of high amylose maize (amylomaize) starch granules on the survival of Bifidobacterium spp. in the mouse intestinal tract显示文摘 | X.Wang I. L.Brown A. J.Evans P. L.Conway | 2001 | Journal of Applied Microbiology2001，，5： | 1 |
| 13 | Comparative Molecular Field Analysis of Colchicine Inhibition and Tubulin Polymerization for Combretastatins Binding to the Colchicine Binding Site on β-Tubulin显示文摘 | Milton L.Brown Jayson M.Rieger Timothy L.Macdonald * | | 0，，： | 1 |
| 14 | 审美邂逅:泰国、柬埔寨和越南的高棉艺术显示文摘美国芝加哥美术馆典藏的一系列精美高棉雕塑,得益于詹姆斯和玛丽莲·阿尔斯德芙(James and Marilynn Alsdorf)伉俪高雅的审美鉴赏力。本文介绍其中部分藏品,并以此作为界定和讨论高棉美学的框架。文中使用的'高棉'一词,指代的是一种艺术风格。在这一层面上,它囊括了今柬埔寨、泰国、老挝和越南等四国的艺术品。其中,泰国的高棉艺术尤其独特。 | Robert L.Brown 魏紫 | 2015 | 美成在久2015，，6： | 1 |
| 15 | Data Mining and the impact of Missing Data显示文摘 | Marvin L.Brown John F.Kros | | 0，，08： | 1 |
| 16 | Contract–Management Capacity in Municipal and County Governments显示文摘 | Trevor L.Brown MatthewPotoski | 2003 | Public Administration Review2003，，2： | 1 |
| 17 | Regulation of P1-450 Gene Expression by Dimethylbenzanthracene in Human Lung Tumor Cells in Culture显示文摘Polycyclic aromatic hydrocarbons(PAHs),dimethyl beazanthracene(DMBA)and benzo-(a)-pyrene(BaP),stimulate the expression of the P1-450 gene in human lung tumor cells(ChaGo)in culture.A concentration-and time-dependent increase in the level of P1-450 specific mRNA sequences hasbeen observed in ChaGo cells treated with sublethal concentrations of DMBA.Results presentedsuggest that the parent compound causes the induction of P1-450 gene expression.The methylationpattern of the internal“-C-” residues of the “-CCGG-” sequence has been studied in a stretch ofabout 8000 base pairs(bp)of DNA sequence in and around the P1-450 gene in the control andDMBA-treated ChaGo cells.A comparative Southern blot analysis of the Msp Ⅰ/Hpa Ⅱ digestedDNA of the control and DMBA-treated ChaGo cells followed by hybridization with ^(32)P-labelledregion-specific probes,revealed that i)the internal “-C-” residues of the “-CCGG-” sequences ofdifferent regions of P1-450 gene were methylated to different degrees;ii)DMBA treatment of thecells induced hypomethylation of only the 5' end “-CCGG-” sequences of the gene;and iii)themethylation patterns of “-CCGG-” sequences of most of the coding region and of the 3' end regionof P1-450 gene were not affected by such DMBA treatment. | 费云标 Kirstin L.Brown Debajit K.Biswas | 1992 | Developmental and Reproductive Biology1992，1，1： | 0 |
| 18 | 冠带层新平台技术显示文摘 | Jean-Francois Fritsch Peter B. Rim Donald L.Brown 涂学忠 | 2004 | 轮胎工业2004，24，2： | 0 |
| 19 | Development and progression of cancer cachexia:Perspectives from bench to bedside显示文摘Cancer cachexia(CC)is a devastating syndrome characterized by weight loss,reduced fat mass and muscle mass that affects approximately 80%of cancer patients and is responsible for 22%-30%of cancer-associated deaths.Understanding underlying mechanisms for the development of CC are crucial to advance therapies to treat CC and improve cancer outcomes.CC is a multi-organ syndrome that results in extensive skeletal muscle and adipose tissue wasting;however,CC can impair other organs such as the liver,heart,brain,and bone as well.A considerable amount of CC research focuses on changes that occur within the muscle,but cancer-related impairments in other organ systems are understudied.Furthermore,metabolic changes in organ systems other than muscle may contribute to CC.Therefore,the purpose of this review is to address degenerative mechanisms which occur during CC from a whole-body perspective.Outlining the information known about metabolic changes that occur in response to cancer is necessary to develop and enhance therapies to treat CC.As much of the current evidences in CC are from pre-clinical models we should note the majority of the data reviewed here are from preclinical models. | Seongkyun Lim Jacob L.Brown Tyrone A.Washington Nicholas P.Greene | 2020 | Sports Medicine and Health Science2020，2，4： | 0 |
| 20 | The structure of colloidal polyethylenimine-silica nanocomposite microparticles显示文摘Deposition of silica from an organosilane tetraethoxysilane(TEOS)onto parent polyethylenimine(PEI)microgel particles produces a novel PEI-silica nanocomposite,which possesses greater adsorption ca-pacity for copper ions than either parent material.This study explores factors governing interactions of silica with the PEI matrix,along with structural features of resulting PEI-silica composite particles,to explain their properties and determine their application potential.The influence of initial TEOS/PEI mass ratio and the duration of silica deposition on the final silica content and distribution in the composite are studied.A comparative analysis of the structural architecture of chemically etched silica remnants,original PEI-silica composite particles and the parent PEI-microgel is carried out using X-ray photo-electron spectroscopy,small-angle X-ray scattering,and electron microscopy techniques.It is found that silica sol nanoparticles are evenly distributed throughout the PEI-microgel framework and interlinked with it via electrostatic interactions,enabling a structural model of the PEI-silica nanocomposite to be proposed.The chemical stability of resulting nanocomposite particles in parallel with the parent PEI-microgel is tested and shown to be robust for more than 100 days of storage in aqueous dispersions across a range of pH conditions,highlighting the application potential for these particles in copper capture. | Alexandra Semenova Luke W.Giles Mark Louis P.Vidallon Bart Follink Paul L.Brown Rico F.Tabor | 2023 | Particuology2023，，5： | 0 |
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