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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | Mouse embryos cloned from brain tumors显示文摘Cancer cells escape from growth cont rol by accumulating genetic and epig enetic alterations.In rare instances,epigenetic changes alone are oncogenic.Furthermore,a gents that modify DNA methylation or chromatin structure can restore a normal phenotype to cells harboring oncogenic mutations.How ever,it is unclear to what extent epi genetic reprogramming can reverse o ncogenesis.Using somatic nuclear transfer,we show that medul loblastomas arising in Ptc1+/-mice can direct preimplantation develop ment.Additionally,blastocysts derived from medullobl astoma nuclei form postimplantatio n embryos with typical cell layers.T hus,tumor cells can be epigenetically reprogrammed into n ormal cell types.This approach coul d lead to a general strategy for assessing genetic and epigenetic contributions to tumorigenesis. | Li L Connelly MC Wetmore C Curran T Morgan JI | 2003 | 癌症2003，22，7： | 11 |
| 3 | 蛋白酶和木聚糖酶对育肥猪的生长性能、营养消化率以及粪便气味的影响显示文摘菜籽粕(RSM)和小麦干酒糟及其可溶物(DDGS)作为副产物可应用到猪的日粮中。然而,与小麦和豆粕型日粮相比,RSM和DDGS中含有较高的非淀粉多糖(NSP),其可限制猪对日粮的有效利用。采用2×2因素试验设计研究生长育肥猪饲粮中添加木聚糖酶(0和200mg·kg-1)和蛋白酶(0和200mg·kg-1)对其生长性能、胴体品质、表观回肠消化率、全消化道养分消化率及粪便气体排放的影响及两种酶之间的相互作用。试验1,对猪的生长性能进行评估。将体重为34.2±2.1kg的育肥猪128头随机分配到4个处理组:以DDGS(300g·kg-1)和RSM(210g·kg-1)的基础日粮;基础日粮中添加蛋白酶200mg·kg-1;基础日粮中添加木聚糖酶200mg·kg-1;基础日粮中添加蛋白酶200mg·kg-1和木聚糖酶200mg·k-1。试验1中,在生长育肥-出栏期间(0~出栏),日粮中添加蛋白酶的试验猪较不添加蛋白酶的试验猪相比具有较低的平均日增重(ADG)(P〈0.001)。生长阶段(0—28d),蛋白酶和木聚糖酶对猪的日均采食量(ADFI,P〈0.01)和体重(BW,P〈0.01)的影响存在相互作用。在育肥阶段(28d~出栏),日粮中添加蛋白酶和木聚糖酶的试验猪与仅添加一种没酶的试验猪相比具有较低的ADFI和BW。然而,蛋白酶和木聚糖酶的相互作用在生长期间(0~28d)内并不显著。试验2,选择体重78±2.3kg公猪24只,将其置于代谢笼中进行代谢试验,试验期间按照试验l中的日粮进行饲喂。木聚糖酶和蛋白酶对总能(GE)中的AID存在相互作用(P〈0.05)。与对照组相比,饲粮中添加蛋白酶可以增加GE中的AID,但饲粮中添加两种酶时可降低GE中的AID。饲粮中添加木聚糖酶交不添加木聚糖组相比,猪粪便的臭气排放量降低(598和1306OuE/m3;P〈0.05)。研究表明,蛋白酶可提高GE的AID;木聚糖酶可以减少粪便异味的排放,然而当生长猪育肥以RSM和DDGS为基础饲粮时,两种酶均不能提高其生长性能。 | O'Shea C J Mc Alpine P O Solan P Curran T Varley P F Walsh A M Doherty J V O | 2014 | 饲料博览2014，0，10： | 4 |
| 4 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 5 | Crystal structure of a TAF1-TAF7 complex in human transcription factor liD reveals a promoter binding module显示文摘 | Hui Wang Elizabeth C Curran Thomas R Hinds Edith H Wang Ning Zheng | 2014 | Cell Research2014，24，12： | 2 |
| 6 | Experimental mixing study of a yield stress fluid in a laminar stirred tank显示文摘 | Curran S J Hayes R E Afacan A Williams M C | 2000 | Ind Eng Chem Res2000，39，1： | 1 |
| 7 | Phase HI comparison of sequential vs concurrent chemoradiation of pts with unresected stage III non-small cell lung cancer ( NSCLC ) 显示文摘 | Curran W Scott C Langer C | 2000 | J Clin Oncol2000，19，： | 1 |
| 8 | Chemerin, a novel adipokine in the regulation of angiogenesis显示文摘 | BOZAOGLU K CURRAN J E STOCKER C J | 2010 | J Clin Endoerinol Metab2010，95，： | 1 |
| 9 | Application of laser capture microdissection and proteomics in colon cancer显示文摘 | Lawrie L C Curran S Mcleod H L | 2001 | Mol Pathol2001，54，4： | 1 |
| 10 | A burden to others: a common source of distress for the terminally ill 显示文摘 | Wilson K G Curran D McPherson C J | 2005 | Cogn Behav Ther2005，34，2： | 1 |
| 11 | A Comprehensive Modeling Study of n-heptane Oxidation显示文摘 | Curran H J Gaffuri P Pitz W J Westbrook C K | 1998 | Combust Flame1998，114，： | 1 |
| 12 | Younger age as a prog- nostic indicator in breast cancer: a cohort study 显示文摘 | Kheirelseid EI-I Boggs JM Curran C | 2011 | BMC Cancer2011，11，： | 1 |
| 13 | Patent indicators for monitoring convergence-examples from NFF and ICT 显示文摘 | Curran C S Leker J | 2011 | Technological Forecasting and Social Change2011，78，2： | 1 |
| 14 | Informatics competencies for nurses at four levels of practice显示文摘 | Staggers N Gassert CA Curran C | 2001 | Journal of Nursing Education2001，4，7： | 1 |
| 15 | Phase III comparison of sequential versus concurrent chemoradiation for PTS with unresected stage III non-small cell lung cancer(NSCLC):initial report of Radiation Therapy Oncology Group(RTOG)9410显示文摘 | Curran W J Jr Scott C Langer C | 2000 | Proc Am Soc Clin Annu Meet2000，19，： | 1 |
| 16 | Method for isolation of human ventricular myocytes from single endocardial and epicardial biopsies显示文摘 | Sanguinetti MC Jiang C Curran ME | 1995 | Am J Physiol1995，268，42： | 1 |
| 17 | Do elderly patients (pts) with locally advanced non-small cell lung cancer (NSCLC) benefit from combined modality therapy ? a secondary analysis of RTOG 94 - 10 显示文摘 | Langer C J Hsu C Curran W | 2002 | Int J Radiat Oncol Biol Physics2002，51，31： | 1 |
| 18 | A Delphi study to determine informatics competenciesfor nurses at four levels of practice 显示文摘 | Staggers N Gassert C Curran C | 2002 | Nursing Research2002，51，6： | 1 |
| 19 | Superoxideproduction by porcine retinal pigment epithelium in vitro 显示文摘 | DOREY C K KHOURI G G SYNIUTA L A CURRAN S A WEITER J J | 1989 | Invest Ophthalmol Vis Sci1989，30，6： | 1 |
| 20 | Use of the Human Patient Simula- tor to Teach Clinical Judgment Skills in a Baccalaureate Nursing Program显示文摘 | Rhodes MLI Curran C | 2005 | Comput Inform Nurs2005，23，5： | 1 |
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