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| 1 | Mouse embryos cloned from brain tumors显示文摘Cancer cells escape from growth cont rol by accumulating genetic and epig enetic alterations.In rare instances,epigenetic changes alone are oncogenic.Furthermore,a gents that modify DNA methylation or chromatin structure can restore a normal phenotype to cells harboring oncogenic mutations.How ever,it is unclear to what extent epi genetic reprogramming can reverse o ncogenesis.Using somatic nuclear transfer,we show that medul loblastomas arising in Ptc1+/-mice can direct preimplantation develop ment.Additionally,blastocysts derived from medullobl astoma nuclei form postimplantatio n embryos with typical cell layers.T hus,tumor cells can be epigenetically reprogrammed into n ormal cell types.This approach coul d lead to a general strategy for assessing genetic and epigenetic contributions to tumorigenesis. | Li L Connelly MC Wetmore C Curran T Morgan JI | 2003 | 癌症2003，22，7： | 11 |
| 2 | Auditory brain- stem response in obstructive sleep apnea 显示文摘 | Wetmore SJ Henderson C Doshier NW | 1988 | Laryngoscope1988，98，5： | 1 |
| 3 | Regulation of brain derived neurotrophic factor(BDNF)expression and release from hippocampal neurosis mediated by non NMDA type glutamate receptors显示文摘 | Wetmore C Olson L Bean AJ | 1994 | J Neurosci1994，14，： | 1 |
| 4 | Localization of brain- derived neurotrophic factors mRNA to neurons in the brain by in situ hybridization 显示文摘 | Wetmore C Emfors P Persson H | 1990 | Exp Neuro1990，109，： | 1 |
| 5 | Dynamic patterns of BDNF expression in injuredsensory neurons: differential modulation by NGFand NT-3显示文摘 | Karchewski LA Gratto KA Wetmore C | 2002 | Eur J Neurosci2002，16，8： | 1 |
| 6 | Auditory brain stem response in obstructive sleep apnea patients 显示文摘 | Wetmore SJ Henderson C Doshier NW | 1988 | Laryngo scope1988，98，5： | 1 |
| 7 | The prediction of equilibrium thermal comfort from physical data on fabrics显示文摘 | Hardy H B Ballou J W Wetmore O C | 1953 | Textile Research Journal1953，23，1： | 1 |
| 8 | The photolysis of methylamine 显示文摘 | Wetmore O C Austin T H | 1944 | Journal of Chemical Physics1944，12，： | 1 |
| 9 | Loss of p53 but not ARF ac- celerates medulloblastoma in mice heterozygous for patched 显示文摘 | Wetmore C Eberhart DE Curran T | 2001 | Cancer Res2001，61，2： | 1 |
| 10 | The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched 显示文摘 | Wetmore C Eberhart DE Curran T | 2000 | Cancer Res2000，60，8： | 1 |
| 11 | Idetification of cell in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family显示文摘 | Emfors P Wetmore C Olson L | 1990 | Neuron1990，，6： | 1 |
| 12 | Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched显示文摘 | Wetmore C Eberhart DE Curran T | 2001 | Cancer Res2001，61，2： | 1 |
| 13 | Enhanced synthesis of brainderived neurotrophic factor in the lensioned peripheral nerve: Different mechanisms are responsible for the regulation of BDNF and NGP mRNA显示文摘 | Meyor M Matsuoka I Wetmore C | 1992 | J Cell Biol1992，119，1： | 1 |
| 14 | Sonic hedgehog in normal and neoplastic proliferation:insight gained from human tumors and animal models 显示文摘 | Wetmore C | 2003 | Curr Opin Genet Dev2003，13，1： | 1 |
| 15 | Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are reponsible for the regulation of BDNF and NGF mRNA 显示文摘 | Meyer M Matsuoka I Wetmore C | 1992 | J Cell Biol1992，119，1： | 1 |
| 16 | Sonic hedgehog in normal and neoplastic proliferation:insight gained from human tumors and animal models显示文摘 | WETMORE C | 2003 | Cur Opin2003，13，： | 1 |
| 17 | A molecular fingerprint for medulloblastoma显示文摘Medulloblastoma is the most common malignant pediatric brain tumor. In mice, Ptcl haploinsufficiency and disruption of DNA repair (DNA ligase IV inactivation) or cell cycle regulation (Kipl, Ink4d, or Inkd.c inactivation), in conjunction with p53 dysfunction, predispose to medulloblastoma. To identify genes important for this tumor, we evaluated gene expression profiles in medulloblastomas from these mice. Unexpectedly, medulloblastoma | Lee Y Miller HL Jensen P Hernan R Connelly M Wetmore C Zindy F Roussel MF Curran T Gilbertson RJ McKinnon PJ | 2003 | 中国神经肿瘤杂志2003，1，3： | 1 |
| 18 | Dynamic patterns of BDNF expression in injured sensory neurons:differential modulation by NGF and NT-3显示文摘 | Karchewski L A Gratto K A Wetmore C | 2002 | Eur J Neurosci2002，16，： | 1 |
| 19 | Enhanced synthesis of brain derived neurotrophic factor in the lesioned peripheral nerve:different mechanisms are responsible for the regulation of BDNF & NGFmRNA显示文摘 | Meyer M Matsuoka I Wetmore C | 1992 | J Cell Biol1992，119，： | 1 |
| 20 | Ureaplasma urealyticum is associated withnongonococcal urethritis among men with fewerlifetime sexual partners:a case-control study 显示文摘 | WETMORE C M MANHART L E LOWENS M S | 2011 | JInfect Dis2011，204，8： | 1 |
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