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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Clinical targeting of the TNF and TNFR superfamilies 显示文摘 | Croft M Benedict C A Ware C F | 2013 | Nat Rev Drug Discov2013，12，2： | 1 |
| 3 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 4 | Annual Consultation Prevalence of Regional Museuloskel- etal Problems in Primary Care : Anobservational Study 显示文摘 | Jordan KP Kadam UT Hayward R Porcheret M Young C Croft P | 2010 | BMC Musculoskelet Disord2010，11，： | 1 |
| 5 | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial显示文摘 | Natalie C Ward Jason HY Wu Michael W Clarke Ian B Puddey Valerie Burke Kevin D Croft Jonathan M Hodgson | 2007 | Journal of Hypertension2007，，1： | 1 |
| 6 | Effect of temper- ature, moisture, soil type and Trichoderma species on the survival of Fusarium pseudograminearum in wheat straw显示文摘 | Wong P T W Mead J A Croft M C | 2002 | Australasian Plant Pathology2002，31，3： | 1 |
| 7 | Inhibition of leukotriene and platelet activating factor synthesis in leukocytes by the sesquiterpene lactone scandenolide显示文摘 | Ysrael M C Croft K D | 1990 | Planta medica1990，56，3： | 1 |
| 8 | Sleep nasendoscopy: a technique of assessment in snoring and obstructive sleep apnoea显示文摘 | CROFT C B PRINGLE M | 1991 | Clin Otolaryngol Allied Sci1991，16，： | 1 |
| 9 | Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals显示文摘 | Dubey C Croft M Swain L | 1996 | J Immunol1996，157，6： | 1 |
| 10 | Chondrogenic and adipogenic potential of microvascular pericytes 显示文摘 | Farrington-Rock C Crofts NJ Doherty M J etal | 2004 | Circulation2004，110，15： | 1 |
| 11 | Accessory molecule and co-stimulation re- quirements for CD4 T cell response 显示文摘 | Croft M Dubey C | 1997 | Crit Rev Immunol1997，17，1： | 1 |
| 12 | The Chlamydomonas genome reveals the evolution of key animal and plant functions 显示文摘 | Merchant S S Prochnik S E Vallon O Harris E H Karpowicz S J Witman G B Terry A Salamov A Fritz-Laylin L K Marechal- Drouard L Marshall W F Qu L H Nelson D R Sanderfoot A A Spalding M H Kapitonov V V Ren Q Ferris P Lindquist E Shapiro H Lucas S M Grimwood J Schmutz J Cardol P Cerutti H Chanfreau G Chen C L Cognat V Croft M T Dent R Dutcher S Fernandez E Fukuzawa H Gonzalez-Ballester D Gonzalez-Halphen D Hallmann A Hanikenne M Hippler M Inwood W Jabbari K Kalanon M Kuras R Lefebvre P A Lemaire S D Lobanov A V Lohr M Manuell A Meier I Mets L Mittag M Mittelmeier T Moroney J V Moseley J Napoli C Nedelcu A M Niyogi K Novoselov S V Paulsen I T Pazour G Purton S Ral J P Riano-Pachon D M Riekhof W Rymarquis L Schroda M Stern D Umen J Willows R Wilson N Zimmer S LAllmer J Balk J Bisova K Chen C J Elias M Gendler K Hauser C Lamb M R Ledford H Long J C Minagawa J Page M D Pan J Pootakham W Roje S Rose A Stahlberg E Terauchi A M Yang P Ball S Bowler C Dieckmann C L GIadyshev V N Green P Jorgensen R Mayfield S Mueller-Roeber B Rajamani S Sayre R T Brokstein P Dubchak I Goodstein D Hornick L Huang Y W Jhaveri J Luo Y Martinez D Ngau W C Otillar B Poliakov A Porter A Szajkowski L Werner G Zhou K Grigoriev I V Rokhsar D S Grossman A R | 2007 | Science2007，318，5848： | 1 |
| 13 | Sleep nasoendoscopy: a technique of assessment in snoring and obstructive sleep apnea显示文摘 | CROFT C B PRINGLE M | 1991 | Clin Otolaryngol1991，16，： | 1 |
| 14 | Ce valence variation in intermetallic alloys:L3 absorption spectroscopy results显示文摘 | Croft M Neifeld R Segre C U | | 0，，： | 1 |
| 15 | Accessory molecule and costimulation requirements for CD4+T cell response显示文摘 | Croft M Dubey C | 1997 | Crit Rev Immunol1997，1，1： | 1 |
| 16 | Oxidative stress in human hypertension: association with antihypertensive treatment, gender, nutrition, and lifestyle显示文摘 | Natalie C Ward Jonathan M Hodgson Ian B Puddey Trevor A Mori Lawrence J Beilin Kevin D Croft | 2003 | Free Radical Biology and Medicine2003，，2： | 1 |
| 17 | Accessory molecule and costimula- tion requirements for CD4 T cell response 显示文摘 | CROFT M DUBEY C | 1997 | Critical Re- views in Immunology1997，17，1： | 1 |
| 18 | Infant-mother Attachment at One Year Predicts Children's Understanding of Mixed Emotions at Six Years显示文摘 | Steele H Steel M Croft C | 1999 | Social Development1999，8，2： | 1 |
| 19 | Sleep nasendoscopy:a technique of assessment in snoring and obstructive sleep apnea显示文摘 | CROFT C B PRINGLE M | 1991 | Clin Otolaryngol1991，16，： | 1 |
| 20 | Early attachment predicts emotion recognition at 6 and 11 years old显示文摘 | Steele H Steele M Croft C | | 0，，04： | 1 |
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