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| 1 | Methodology for high-quality studies on course and prognosis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are characterized by a chronic course with an alternation of relapses and remissions.Questions about prognosis are important for the patient who wants to know how the disease will affect his/her life and also for clinicians to make management decisions.Correct selection of the patients is the basis for good methodological studies on the course of IBD.A great proportion of data on the course of IBD is derived from a limited number of cohort studies.Studies help to define the endpoints for clinical trials and to identify subsets of patients in whom the prognosis of the disease can be stratified according to clinical features.Specific scientific requirements for high-quality studies on prognosis are the following:use of inception cohort,description of referral patterns,completeness of follow-up,objective outcome criteria,blind outcome assessment,adjustment for extraneous prognostic factors and statistical issues.We analyzed each of these requirements in studies on IBDs.To date,prospective and populationbased cohort studies are the standard for an unbiased assessment of prognosis.A better knowledge of the course of disease of chronic disorders ideally requires:(1) data from population-based studies,to avoid selection bias from referral centers in which patients with a more severe disease are usually treated;(2) inclusion of patients seen at the onset of the disease excluding misdiagnosed cases;and(3) follow-up from the onset of the disease to the end without dropouts. | Irene Modesto Giovanni Perricone Ambrogio Orlando Mario Cottone | 2012 | World Journal of Gastroenterology2012，18，29： | 7 |
| 2 | Selection of patients with hepatocellular carcinoma for livertransplantation:Past and future显示文摘The aim of liver transplantation(LT) for hepatocellular carcinoma(HCC) is to ensure a rate of disease-free survival similar to that of patients transplanted due to benign disease. Therefore, we are forced to adopt strict criteria when selecting candidates for LT and prioritizing patients on the waiting list(WL), to have clarified indications for bridging therapy for groups at risk for progression or recurrence, and to establish certain limits for downstaging therapies. Although the Milan criteria(MC) remain the standard and most employed criteria for indication of HCC patients for LT by far, in the coming years, criteria will be consolidated that take into account not only data regarding the size/volume and number of tumors but also their biology. This criteria will mainly include the alpha fetoprotein(AFP) values and, in view of their wide variability, any of the published logarithmic models for the selection of candidates for LT. Bridging therapy is necessary for HCC patients on the WL who meet the MC and have the possibility of experiencing a delay for LT greater than 6 mo or any of the known risk factors for recurrence. It is difficult to define single AFP values that would indicate bridging therapy(200, 300 or 400 ng/m L); therefore, it is preferable to rely on the criteria of a French AFP model score > 2. Other single indications for bridging therapy include a tumor diameter greater than 3 cm, more than one tumor, and having an AFP slope greater than 15 ng/m L per month or > 50 ng/m L for three months during strict monitoring while on the WL. When considering the inclusion of patients on the WL who do not meet the MC, it is mandatory to determine their eligibility for downstaging therapy prior to inclusion. The upper limit for this therapy could be one lesion up to 8 cm, 2-3 lesions with a total tumor diameter up to 8 cm, or a total tumor volume of 115 cm^3. Lastly, liver allocation and the prioritization of patients with HCC onthe WL should take into account the recently described HCC model for end-stage liver disease, which considers hepatic function, HCC size and the number and the log of AFP values. This formula has been calibrated with the survival data of non-HCC patients and produces a dynamic and more accurate assessment model. | Arturo Soriano Aranzazu Varona Rajesh Gianchandani Modesto Enrique Moneva Javier Arranz Antonio Gonzalez Manuel Barrera | 2016 | World Journal of Hepatology2016，8，1： | 6 |
| 3 | A tale of worldwide success:Behind the scenes of Carex(Cyperaceae)biogeography and diversification显示文摘The megadiverse genus Carex(c.2000 species,Cyperaceae)has a nearly cosmopolitan distribution,displaying an inverted latitudinal richness gradient with higher species diversity in cold-temperate areas of the Northern Hemisphere.Despite great expansion in our knowledge of the phylogenetic history of the genus and many molecular studies focusing on the biogeography of particular groups during the last few decades,a global analysis of Carex biogeography and diversification is still lacking.For this purpose,we built the hitherto most comprehensive Carex-dated phylogeny based on three markers(ETS-ITS-matK),using a previous phylogenomic Hyb-Seq framework,and a sampling of two-thirds of its species and all recognized sections.Ancestral area reconstaiction,biogeographic stochastic mapping,and diversification rate analyses were conducted to elucidate macroevolutionary biogeographic and diversification patterns.Our results reveal that Carex originated in the late Eocene in E Asia,where it probably remained until the synchronous diversification of its main subgeneric lineages during the late Oligocene.E Asia is supported as the cradle of Carex diversification,as well as a< | Santiago Martin-Bravo Pedro Jimenez-Mejias Tamara Villaverde Marcial Escudero Marlene Hahn Daniel Spalink Eric H.Roalson Andrew L.Hipp the Global Carex Group Carmen Benitez-Benitez Leo P.Bruederle Elisabeth Fitzek Bruce A.Ford Kerry A.Ford Mira Gamer Sebastian Gebauer Matthias H.Hoffmann Xiao-Feng Jin Isabel Larridon Etienne Ldveilld-Bourret Yi-Fei Lu Modesto Luceno Enrique Maguilla Jose Ignacio Marquez-Corro Monica Miguez Robert Naczi Anton A.Reznicek Julian R.Starr | 2019 | Journal of Systematics and Evolution2019，57，6： | 6 |
| 4 | Assessing the sensitivity of divergence time estimates to locus sampling, calibration points, and model priors in a RAD-seq phylogeny of Carex section Schoenoxiphium显示文摘Restriction site-associated DNA sequencing(RAD-seq)and related methods have become relatively common approaches to resolve species-level phylogeny.It is not clear,however,whether RAD-seq data matrices are well suited to relaxed clock inference of divergence times,given the size of the matrices and the abundance of missing data.We investigated the sensitivity of Bayesian relaxed clock estimates of divergence times to alternative analytical decisions on an empirical RAD-seq phylogenetic matrix.We explored the relative contribution of secondary calibration strategies,amount of missing data,and the data partition analyzed to overall variance in divergence times inferred using BEAST MCMC analyses of Carex section Schoenoxiphium(Cyperaceae)-a recent radiation for which we have nearly complete species sampling of RAD-seq data.The crown node for Schoenoxiphium was estimated to be 15.22(9.56-21.18)Ma using a single calibration point and low missing data,11.93(8.07-16.03)Ma using multiple calibration points and low missing data,and 8.34(5.41-11.22)using multiple calibrations but high missing data.We found that using matrices with more than half of the individuals with missing data inferred younger mean ages for all nodes.Moreover,we have found that our molecular clock estimates are sensitive to the positions of the calibration(s)in our phylogenetic tree(using matrices with low missing data),especially when only a single calibration was applied to estimate divergence times.These results argue for sensitivity analyses and caution in interpreting divergence time estimates from RAD-seq data. | Tamara Villaverde Enrique Maguilla Modesto Luceno Andrew L.Hipp | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 5 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 6 | Is 5-ASA Still the Treatment of Choice for Ulcerative Colitis?显示文摘 | Mario Cottone Sara Renna Irene Modesto Ambrogio Orlando | 2011 | Current Drug Targets2011，，10： | 2 |
| 7 | 连续夺获阈值监测与自动调节起搏器刺激输出——MICRONY SR+起搏器多中心研究显示文摘目的:本研究评价具有心室自动夺获功能的 Microny 起搏器的安全性及功效。方法:自1994年11月至1996年9月欧洲国家的16个医学中心,共有113例植入 Microny 起搏器的患者进入了研究。所有植入的起搏器采用了 Pacesetter 的低极化、双极电极导线(Membrane 1402 T)。患者在出院时及出院后1、3、6、12个月分别进行随访。结果:在植入后1个月的随访中,动态心电图显示所有未夺获的心搏均有后备起搏脉冲(4.5 V/0.49 ms)出现。植入时测试自身 R 波高度为14.7±7.4 mV,刺激除极波高度(ER)为10.2±4.8 mV。这些数值随时间推移保持稳定,但二者无相关性(r=0.29),植入时,由VARIO 功能测试的起搏阈值为0.5±0.2 V,由自动夺获功能测试的阈值为0.6±0.3 V。两种方法测试的起搏阈值在各次随访中相关性较好(r=0.79),平均差异为0.11 V。后备起搏脉冲占起搏刺激的1.1%。发放后备起搏脉冲的原因为未能夺获(7.1%);(伪)融合波(87.0%);ER 感知低下(0.5%)和QRS 感知低下(4.1%)。在自动夺获功能打开时,起搏电流总消耗为1.4 A。结论:本研究证明了自动夺获功能根据当时的起搏阈值安全和可靠地调节起搏器的输出,为患者提供最大的安全性并延长起搏器的使用寿命。 | Malcolm Clarke Bo Liu Hans Schller Ludwig Binner Charles Kennergren Modesto Guerola Peter Weinmann Ole Jorgen Ohm | 1997 | 中华心律失常学杂志1997，1，2： | 2 |
| 8 | Predicting factors of long-term results of OKT3 therapy for steroid resistant acute rejection following cadaveric renal transplantation 显示文摘 | Rostating L Chabannier M H Modesto A | 1999 | Am J Nephrol1999，19，6： | 2 |
| 9 | Two dimensional alacous- tic pattern derived Strain araeters closely correlate with one- imensional tissue Doppler drived strain measurent显示文摘 | Modesto KM auduros DispenzieriA etal | 2006 | Eurj Echo- eardiogr2006，，： | 1 |
| 10 | Cord blood interleukin-6 as a predictor of early-onset neonatal sepsis显示文摘 | Cernada M Badia N Modesto V | 2012 | Acta Paediatr2012，101，5： | 1 |
| 11 | Gastrointestinal stromal tumor:spiral computed tomography features and pathologic correlation显示文摘 | DA RONCH T MODESTO A BAZZOCCHI M | 2006 | Radiol Med2006，111，5： | 1 |
| 12 | Unsuspected tuberculosis in COPD and use of levo- floxacin: diagnostic challenges显示文摘 | Modesto dos Santos V Martins RR Fachinelli LR | 2014 | Infez Med2014，22，4： | 1 |
| 13 | Molecular characterization and expression pattern of zona pellucida proteins in gilthead seabream(Sparus aurata)显示文摘 | Modig C Modesto T Canzrio A | 2006 | Biology of Reproduction2006，75，： | 1 |
| 14 | Quantitative assessment of regional myocardial deformation by a novel two-dimensional (acoustic pattern tracking) strain echocardiography:clinical validation using tissue Doppler measurment显示文摘 | Modesto K Cauduro S Dispenzier A | 2004 | J Am Soc Echocardiography2004，17，5： | 1 |
| 15 | Evaluation and aaanagement of acute radiation dermatitis显示文摘 | Modesto A Faivre J C Granel-Brocard F | 2012 | Cancer Radiother2012，16，56： | 1 |
| 16 | Experimental assessment of energy saving due to trains regenerative braking in an electrified subway line 显示文摘 | AD1NOLFI A LAMEDICA R MODESTO C | 1998 | IEEE Transactions on Industry applica- tions1998，13，4： | 1 |
| 17 | Experimental assessment of energy saving due to trains regenerative braking in an electrified subway line显示文摘 | Adinolfi A Lamedica R Modesto C | 1998 | Power Delivery IEEE Transactions on1998，13，4： | 1 |
| 18 | Diagnosis and treatment of alcohol - dependent patients with comorbid psychiatric disorders 显示文摘 | Modesto - Lowe V Kranzler HR | 1999 | Alcohol Res Health1999，23，2： | 1 |
| 19 | Mesalazine for the treatment of inflammatory bowel disease显示文摘 | CRISCUOLI V MODESTO I ORLANDO A | 2013 | Expert Opin Pharmacother2013，14，12： | 1 |
| 20 | Surface characterization of a corroded bronze-leaded alloy in a salt spray cabinet 显示文摘 | Joao Cura D'Ars de Figueiredo Junior Vanessa de Freitas Cunha Lins Vito Modesto De Bellis | 2007 | Applied Surface Science2007，，253： | 1 |
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