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| 1 | NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients显示文摘AIM:To investigate the small bowel of seronegative spondyloarthropathy(SpA) patients in order to ascertain the presence of mucosal lesions.METHODS:Between January 2008 and June 2010,54 consecutive patients were enrolled and submitted to avideo capsule endoscopy(VCE) examination.Historyand demographic data were taken,as well as the history of non-steroidal anti-inflammatory drug(NSAID) consumption.After reading each VCE recording,a capsule endoscopy scoring index for small bowel mucosal inflammatory change(Lewis score) was calculated.Statistical analysis of the data was performed.RESULTS:The Lewis score for the whole cohort was 397.73.It was higher in the NSAID consumption subgroup(P = 0.036).The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel,but not for its distal third(P values of 0.036,0.001 and 0.18,respectively).There was no statistical significant difference between the groups with regard to age or sex of the patients.CONCLUSION:The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel,but not for its distal part. | Mihai Rimba■ Mǎdǎlina Marinescu Mihail Radu Voiosu Cristian Rǎsvan Bǎicu■ Simona Caraiola Adriana Nicolau Doina Ni■escu Georgeta Camelia Badea Magda Ileana Parvu | 2011 | World Journal of Gastroenterology2011，17，8： | 1 |
| 2 | Inflammatory bowel disease-associated spondyloarthropathies显示文摘This issue presents a symposium held in Messina talking about inflammatory bowel disease(IBD) and associated spondyloarthropathies.The topic covers epidemiology and clinical manifestations of IBD-related arthropathies, common genetic and immunologic features, combined therapies for gut and joint inflammation, and future biologic therapies etc.I believe this series of articles will deeply facilitate understanding of and the approach to IBD and associated arthropathies. | Walter Fries | 2009 | World Journal of Gastroenterology2009，15，20： | 0 |
| 3 | 非甾体类抗炎药与肠道损伤研究进展显示文摘非甾体类抗炎药(non—steroidal anti—inflammatory drug,NSAIDs)是一类具有抗炎、解热、镇痛等作用的药物,是目前全球使用最广泛的一类处方药,但长期大量使用,可引起各种毒副作用,尤以胃肠道损害最为常见。NSAIDs对胃十二指肠黏膜的损害已受到普遍关注,近年来随着内窥镜技术的不断提高,NSAIDs相关性肠黏膜的损害也开始受到人们的重视。本文就NSAIDs相关性肠道损伤文献作一综述。 | 钱瑾(综述) 孟立娜(审校) | 2010 | 浙江临床医学2010，12，2： | 0 |
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