|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Cardiac rehabilitation and secondary prevention of coronary heart disease 显示文摘 | Leon AS Franklin BA Costa F | 2005 | Circulation2005，111，3： | 1 |
| 3 | Production of the biocontrol agent Pantoea agglomerans strain CPA-2 using commercial products and by-products显示文摘 | E. Costa N. Teixidó J. Usall E. Atarés I. Vi?as | 2001 | 2001 (3-4)2001，，3： | 1 |
| 4 | Lymphomatoid granulomatosis:prospective clinical and therapeutic experience over 10 years显示文摘 | Fauci AS Haynes BF Costa J | 1982 | N Engl J Med1982，306，2： | 1 |
| 5 | Two-year angiographic and intravascular ultrasound follow-up after implantation of sirolimus-eluting stents in human coronary arteries显示文摘 | Sousa JE Costa MA Sousa AG Abizaid AC Seixas AC Abzaid AS | 2003 | Circulation2003，107，3： | 1 |
| 6 | Characteristics of transient evoked otoaeoustic emissions in newborn hearing screening program显示文摘 | Durante AS Carvallo RM da Costa FS | 2005 | Pro Fono2005，17，2： | 1 |
| 7 | Cardiac rehabilitation and secondary prevention of coronary heart disease:an American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise,Cardiac Rehahititation,and Prevention)and the Council on Nutrit显示文摘 | Leon AS Franklin BA Costa F | | 0，，： | 1 |
| 8 | Cardiac rehabilitation and secondary prevention of coronary heart disease:an American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise,Cardiac Rehabilitation,and Prevention) and the Council on Nutrit显示文摘 | Leon AS Franklin BA Costa F | | 0，，03： | 1 |
| 9 | Causes of death in renal transplant recipients:a study of 102 autopsies from 1968 to 1991显示文摘 | Reis MA Costa RS Ferraz AS | 1995 | J R Soc Med1995，88，1： | 1 |
| 10 | The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling 显示文摘 | Nateri AS Riera-Sans L Da Costa C | 2004 | Science2004，303，5662： | 1 |
| 11 | Functional response of Euseius concordis to densities of different developmental stages of the cassava green mite显示文摘 | Costa C Teodoro AV Rêgo AS eta | 2014 | Experimental and Applied Acarology2014，64，： | 1 |
| 12 | Characteristics of transient evoked otoacoustic emissions in newborn hearing screening program显示文摘 | Durante AS Carvallo RM da Costa FS | 2005 | Revista De Atualizacao Cientifica2005，17，： | 1 |
| 13 | Blood-brain bar- rier leakage may lead to progression of temporal lobe epilepsy 显示文摘 | van Vliet EA da Costa AS Redeker S | 2007 | Brain2007，130，： | 1 |
| 14 | Characterization of magnetic mierospheres based on network styrene and divinylbenzene copolymers 显示文摘 | Marcia L C de S Leite M CAM Costa M AS | 2004 | Materials Letters2004，58，24： | 1 |
| 15 | Causes of death in renal transplant recipients: a study of 102 autopsies from 1968 to 1991显示文摘 | Costa RS Ferraz AS | 1995 | J R Soc Med1995，88，1： | 1 |
| 16 | AmpiciUin/sulbactam compared with polymyxins for the treatment of infections caused by carbapenem-resistant Acinetobacter spp 显示文摘 | Oliveira MS Prado GV Costa SF Grinbaum RS Levin AS | 2008 | J Antimicrob Chemother2008，61，6： | 1 |
| 17 | Pleural adenosine deaminase in the diagnostic workup of tuberculous pleural effusion显示文摘 | Reis R Costa AS Conde B | 2014 | Rev Port Pneumol2014，20，4： | 1 |
| 18 | Incidence of peri-intraventricular hemorrhage in preterm newborn infants with birth weight less than 1500 gms: evaluation of brain ultrasonographic studies and necropsy 显示文摘 | Gerpelli JL Santos-Filho AS Silveira JD Tani ME Costa HP | 1992 | Arq Neuropsiquiatr1992，50，3： | 1 |
| 19 | Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study 显示文摘 | Sousa JM Costa MA Abizaid AS | 2000 | Circulation2000，102，： | 1 |
| 20 | Causes of death in renal transplant recipients: a study of 102 autopsies from 1968 to 1991 显示文摘 | Reis MA Costa RS Ferraz AS | 1995 | JRSocMed1995，88，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员