|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma显示文摘AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. | Dénes Grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 2 | Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells显示文摘AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. RESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P < 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P < 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P < 0.05) adhesion to GP202 clones with larger MUC1 VNTR domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa. | Natália R Costa Nuno Mendes Nuno T Marcos Celso A Reis Thomas Caffrey Michael A Hollingsworth Filipe Santos-Silva | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 3 | Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer显示文摘 | Milam M R Frumovitz M dos Reis R | 2007 | Gynecol Oncol2007，106，1： | 1 |
| 4 | Sticky Information Versus Sticky Prices : A Proposal to Replace the New Keynesian Phillips Curve 显示文摘 | Mankiw N G R Reis | 2002 | The Quarterly Jour- nal of Economics2002，，117： | 1 |
| 5 | High performance tangential flow filtration 显示文摘 | van Reis R Gadam S Frautschy L N | 1997 | Biotechnol Bioeng1997，56，： | 1 |
| 6 | Processes used by good computational estimation 显示文摘 | Reys R E Rybolt J E | 1982 | Journal for Research in Mathematics Education1982，13，2： | 1 |
| 7 | Development of a rapid and specific assay for detection of busulfan in human plasma by high-performance liquid chromatography/elect rospray ionization tandem mass spectrometry显示文摘 | Dos Reis EO Vianna-Jorge R Suarez-Kurtz G | | 0，，12： | 1 |
| 8 | Preoperative lymph-vascular space invasion is associated with nodal me- tastases in women with early-stage cervical ancer显示文摘 | Milam MR Frumovitz M dos Reis R | 2007 | Gyne- col Oncol2007，106，1： | 1 |
| 9 | Vapor Bubble Departure in Forced Convection Boiling显示文摘 | Rei R Bernhard D M | 1993 | Int J Heat and Mass Transfer1993，36，： | 1 |
| 10 | Treatment of patients admitted to the hospital with congestive heart failure:Specialty-related disparities in practice patterns and outcomes显示文摘 | REIS S E HOLUBKOV R EDMUNDOWICZ D | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 11 | Optimal location of control valves in pipe networks by genetic algorithm显示文摘 | REIS L F R PORTO R M | 1997 | ASCE Journal of Water Resources Planning and Management1997，123，6： | 1 |
| 12 | Tambourgi, synthesis and characterization of a starch modified hydrogel as potential carrier for drug delivery system显示文摘 | REIS A V GUIHEME M R MOIA T A | 2008 | Journal of Polymer Science Part A: Polymer Chemistry2008，46，7： | 1 |
| 13 | Crypthecodinium cohnii with emphasis on DHA production:a review显示文摘 | Mendes A Reis A Vasconcelos R | 2009 | J Appl Phycol2009，21，2： | 1 |
| 14 | Dexamethasone-loaded scaffolds prepared by supercritical-assisted phase inversion显示文摘 | Duarte A R C Mano J F Reis R L | 2009 | Acta Biomaterialia2009，5，6： | 1 |
| 15 | Recovery of phenol from aqueous solutions using liquid membranes with cyanex 923显示文摘 | Reis M T A De freitas O M Ismael M R C | 2007 | J Membrane Sci2007，305，1： | 1 |
| 16 | Osteochondral defects: Present situation and tissue engineering approaehes显示文摘 | MANO J F REIS R L | 2007 | Journal of Tissue Engineering and Regenerative Medicine2007，1，4： | 1 |
| 17 | Effect of spacing and age on nitrogen and phosphorus distribution in biomass of Eucalyptus camaldulensis,Eucalyptus pellita and Eucalyptus urophylla plantations in southeastern Brazil显示文摘 | Harrison R B Reis G G Reis M D G F | 2000 | Forest Ecology and Management2000，133，3： | 1 |
| 18 | Estimation Performance and Strategies Use of Mexican 5^th and 8^th Grade Student Sample 显示文摘 | Reys R E Reys B J Alfinio F P | 1991 | Educational Students in Mathematics1991，22，4： | 1 |
| 19 | Localization and pattern of expression of a female specific mRNA in Schistosoma mansoni显示文摘 | Reis M G Kuhns J Blanton R | 1989 | Mol Biochem Parasitol1989，32，： | 1 |
| 20 | Sympathetic neuronal surviral induced by retinal trophic factors 显示文摘 | Reis R A Cabral de Silra M C Loureiro dos Santos N E | 2002 | J Neurobiol2002，50，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员