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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Characterization of magnetic mierospheres based on network styrene and divinylbenzene copolymers 显示文摘 | Marcia L C de S Leite M CAM Costa M AS | 2004 | Materials Letters2004，58，24： | 1 |
| 3 | Parkinson's disease and dementia: a longitudinal study (DEMPARK) 显示文摘 | Balzer-Geldsetzer M Costa AS Kronenbtirger M | 2011 | Neuroepi- demiology2011，37，34： | 1 |
| 4 | An experimental investigation of the effect of groove location and supply pressure on the THD performance of a steadily loaded journal bearing显示文摘 | COSTA L FILLON M MIRANDA AS | 2000 | ASME Journal of Tribology2000，122，1： | 1 |
| 5 | A meta-analysis of the most indicated preparation design for porcelain laminate ve- neers显示文摘 | da Costa DC Coutinbo M de Sousa AS | 2013 | J Adhes Dent2013，15，3： | 1 |
| 6 | NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure显示文摘 | Bourajjaj M Armand AS da Costa Martins PA | | 0，，： | 1 |
| 7 | NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure显示文摘 | Bourajjaj M Armand AS da Costa Martins PA | 2008 | Biol Chem2008，283，22： | 1 |
| 8 | Retinal assessment using optical coherence tomography显示文摘 | Costa RA Skaf M Luiz AS M | 2006 | Prog in Ret and Eye Rese2006，25，3： | 1 |
| 9 | Subject-ventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation 显示文摘 | Moerer O Beck J Brander L Costa R Quintel M Slutsky AS | 2008 | Intensive Care Med2008，34，9： | 1 |
| 10 | Surgical treatment of cementoblastoma associated with apicoectomy and endodontic therapy:Case report显示文摘This case report describes the surgical removal of cementoblastoma associated with apicoectomy and endodontic therapy. The patient, an 18-year-old man, presented pain in the region of the mandibular body on the right side. On clinical exam, bone expansion was observed in the region at the bottom of the vestibular sulcus, pain on palpation, slight extrusion of tooth 46 with presence of pulp vitality. Radiographic exams demonstrated the presence of a radiopaque area and discrete radiolucent halo associated with the root of tooth 46, suggesting the diagnosis of cementoblastoma. Endodontic treatment of tooth 46 was performed and exeresis of the lesion by apicoectomy. Twelve months after the first surgery, recurrence of the lesion was observed, and a new apicoectomy was necessary, this time up to the middle third of the root. Clinical radiographic control 12 mo after the second surgical intervention demonstrated absence of signs and symptoms, radiographic repair, with tooth 46 shown to be fully functional. | Bernardo Cesar Costa Guilherme José Pimentel Lopes de Oliveira Maria das Gra?as Afonso Miranda Chaves Renan Roberto da Costa Mário Francisco Real Gabrielli Juliane Maria Guerreiro-Tanomaru Mário Tanomaru-Filho | 2016 | World Journal of Clinical Cases2016，4，9： | 0 |
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