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| 1 | Effects of imidapril on heterogeneity of action potential and calcium current of ventriclar myocytes in infarcted rabbits显示文摘AIM: To investigate the effects of chronic treatment with imidapril on the electrophysiologic heterogeneous change of the noninfarcted myocardium of rabbits after myocardial infarction and the mechanism of its antiarrhythmic efficacy. METHODS: Rabbits with left coronary artery ligation were prepared and allowed to recover for 8 weeks. Myocytes were isolated from subendocardial, midmyocardial, and subepicardial regions of the noninfarcted left ventricular wall. Action potentials and calcium current were recorded using whole-cell patch clamp technique. RESULTS: The action potential duration of repolarization 90 % (APD90) was more prolonged in midmyocardium rather than in subepicardium and subendocardium with healed myocardial infarction. The transmural dispersion of repolarization (TDR) was increased in the three ventricular regions. The amplitude of/Ca-L was enhanced but its density was decreased in noninfarcted ventricular myocytes due to increased cell membrane capacitance. The increased differences of calcium currents among subepicardium, midmyocardium, and subendocardium were also discovered. Normalization of heterogeneous changes in repolarization after treatment with imidapril was observed and decrease of TDR in noninfarcted area was measured. Early after depolarization (EAD) events of noninfarcted midmyocardium were markedly decreased by imidapril. CONCLUSION: Imidapril reduced the electrophysiologic heterogeneities in noninfarcted area in rabbits after myocardial infarction. This ability of imidapril may contribute to its antiarrhythmic efficacy. | Yang LI, Qiao XUE, Jie MA, Cun-tai ZHANG, Ping QIU, Lin WANG Wei GAO ,Rei CHENG,Zai-ying LU, Shi-wen WANGInstitute of Geriatric Cardiology of Chinese PLA General Hospital, Beijing 100085, China Department of Cardiology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China | 2004 | Acta Pharmacologica Sinica2004，25，11： | 7 |
| 2 | Microstructure and mechanical properties of composite resins subjected to accelerated artificial aging 显示文摘 | dos Reis AC de Castro DT Schiavon MA | 2013 | Brazilian dental journal2013，24，6： | 1 |
| 3 | Advances in bacterial exopolysaccharides:from production to biotechnological applications显示文摘 | Freitas F Alves VD Reis MA | 2011 | Trends Biotechnol2011，29，8： | 1 |
| 4 | Rifampicinwarfarin interaction leading to macroscopic hematuria:a case report and review of the literature显示文摘 | Martins MA Reis AM Sales MF | | 0，，14： | 1 |
| 5 | Systemic inflammation enhances surgery-induced cognitive dysfunction in mice显示文摘 | António Rei Fidalgo Mario Cibelli John P.M. White Istvan Nagy Mervyn Maze Daqing Ma | 2011 | Neuroscience Letters2011，，： | 1 |
| 6 | Influence of total face,fa-cial and nasal masks on short-term adverse effects during noninvasive ventilation显示文摘 | Holanda MA Reis RC Winkeler GF | 2009 | J Bras Pneumol2009，35，2： | 1 |
| 7 | Pathogenic mechanisms in HBV - and HCV - associated hepatocellular carcinoma 显示文摘 | Arzumanyan A Reis HM Feitelson MA | 2013 | Nat Rev Cancer2013，13，2： | 1 |
| 8 | A new branch of endoplasmic reticulum-stress signaling and the osmotic signal converge on plant specific asparaginerich proteins to promote cell death 显示文摘 | Costa MD Reis PA Santos MA | 2008 | J Biol Chem2008，283，20： | 1 |
| 9 | Renal transplantation outcomes:a comparative analysis between elderly and younger recipients显示文摘 | Mendon?a HM Dos Reis MA de Castro de Cintra Sesso R | | 0，，06： | 1 |
| 10 | Methodological aspects about in vitro evaluation of antioxidant properties显示文摘 | MAGALH(A)ES LM SEGUNDO MA REIS S | | 0，，01： | 1 |
| 11 | Mitochondrial superoxide dismutase is essential for ethanol tolerance of Saccharomyces cerevisiae in the post-diauxic phase显示文摘 | Costa V Amorim MA Reis E | 1997 | Microbiology1997，143，5： | 1 |
| 12 | Causes of death in renal transplant recipients:a study of 102 autopsies from 1968 to 1991显示文摘 | Reis MA Costa RS Ferraz AS | 1995 | J R Soc Med1995，88，1： | 1 |
| 13 | Kinin B I receptor defieiency leads to leptin hypersensitivity and resistance to obesity 显示文摘 | Mori MA Araujo RC Reis FC | 2008 | Diabetes2008，57，6： | 1 |
| 14 | Rifampicin-warfarin inter- action leading to macroscopic hematuria: a case report and review of the literature显示文摘 | Martins MA Reis AM Sales MF | 2013 | BMC Pharmacol Toxicol2013，14，： | 1 |
| 15 | Causes of death in renal transplant recipients: a study of 102 autopsies from 1968 to 1991显示文摘 | Costa RS Ferraz AS | 1995 | J R Soc Med1995，88，1： | 1 |
| 16 | Low tidal volume ventilation induces proinflammatory and profibrogenic response in lungs of rats 显示文摘 | Caruso P Meireles SI Reis LF Mauad T Martins MA Deheinzelin D | 2003 | Intensive Care Med2003，29，10： | 1 |
| 17 | Chronic labile hypertension produced by lesions of the nucleus tractus solitarii in the cat 显示文摘 | Nathan MA Reis DJ | 1977 | Circ Res1977，40，： | 1 |
| 18 | Causes of death in renal transplant recipients: a study of 102 autopsies from 1968 to 1991 显示文摘 | Reis MA Costa RS Ferraz AS | 1995 | JRSocMed1995，88，： | 1 |
| 19 | Acute renal failure in experimental envenomation with Africanized bee venom显示文摘 | Costa RS Coimbra TM | 1998 | Ren Faill1998，20，： | 1 |
| 20 | Effects of pH,temperature,and ionic strength on adsorption of sodium dodecylben zenesulfonate into Mg-Al-CO3 layered double hydroxides显示文摘 | Ma'rcio Jose' dos Reis Fabiano Silve'rio Jairo Tronto | 2004 | Journal of Physics and Chemistry of Solids2004，65，： | 1 |
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