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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 3 | Comparative analysis of four methods to extract DNA from paraffin-embedded tissues:effect on downstream molecular applications显示文摘 | CORNELIS J J JOHANNES C L PAUL H M S | 2010 | BMC Research Notes2010，239，3： | 1 |
| 4 | Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium)显示文摘 | J Nouwen C Cornelis R De Fré M Wevers P Viaene C Mensink J Patyn L Verschaeve R Hooghe A Maes M Collier G Schoeters R Van Cleuvenbergen P Geuzens | 2001 | Chemosphere2001，，4： | 1 |
| 5 | Preexposure prophylaxis for HIV infection among African women显示文摘 | Van Damme L Corneli A Ahmed K | 2012 | N Engl J Med2012，367，5： | 1 |
| 6 | Determination of arsenic by hydride generation inductively coupled plasma mass spectrometry using a tubular membrane gas-liquid separator显示文摘 | BRANCH S CORNS W T EBDON L | 1991 | Journal of Analytical Atomic Spectrometry1991，6，2： | 1 |
| 7 | Analyst显示文摘 | Vercoutere K Cornelies R Mees L | 1998 | 123: 965-9691998，123，： | 1 |
| 8 | Diagnostic markers of sepsis in the emergency department显示文摘 | Spapen HD Hachimi-Idrissi S Corne L | | 0，，03： | 1 |
| 9 | Mild hypothermia induced by a helmet device:a clinical feasibility study显示文摘 | Hachimi-ldrissi S Corne L Ebinger G | 2001 | Resuscitation2001，51，3： | 1 |
| 10 | Multiple Word DNA Computing on Surfaces显示文摘 | L Wang RM Corn LM Smith el al | 2000 | J Am Chem Soc2000，122，： | 1 |
| 11 | Biocontrol agents in signaling resistance显示文摘 | VAN LOON L C CORNE M J PIETERSE | 2002 | Biological control of crop diseases2002，，： | 1 |
| 12 | Determination of mercury, selenium, bismuth, arsenic and antimony in human hair by microwave digestion atomic fluorescence spectrometry显示文摘 | Rahman L Corns W Bryce D | 2000 | Talanta2000，52，5： | 1 |
| 13 | Three-dimensional analysis of maxillary protraction with inter-maxillary elastics to miniplates显示文摘 | Heymann G C Cevidanes L Cornelis M | 2010 | Am J Orthod Dentofacial Orthop2010，137，20： | 1 |
| 14 | HapX-mediated iron homeostasis is essential forrhizosphere competence and virulence of the soilbornepathogen Fusarium oxysporum显示文摘 | López-Berges MS Capilla J Turrà D Schafferer L Matthijs S J?chl C Cornelis P Guarro J Haas H PietroAD | 2012 | Plant Cell2012，24，38： | 1 |
| 15 | Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes显示文摘 | Qi L Cornelis MC Kraft P | | 0，，： | 1 |
| 16 | A procedure for quantitative regioselective nitration of aromatics hydrocarbons in the laboratory显示文摘 | Cornélis A Delaude L Gerstmatic A | 1988 | Tetrahedron Lett1988，29，44： | 1 |
| 17 | Triassic pelagic deposits of Timor: palaeogeographic and sea-level implications显示文摘 | R Martini L Zaninetti M Villeneuve J.-J Cornée L Krystyn S Cirilli P De Wever P Dumitrica A Harsolumakso | 2000 | Palaeogeography Palaeoclimatology Palaeoecology2000，，1： | 1 |
| 18 | Determination of mercury, selenium, bismuth, arsenic and antimony in human hair by microwave digestion a- tomic fluorescence spectrometry 显示文摘 | RAHMAN L CORNS W T BRYCE D W | 2000 | Talanta2000，52，： | 1 |
| 19 | Mild hypothermia induced by a helmet device: a clinical feasibility study显示文摘 | Corne L Ebinger G | 2001 | Resuscitation2001，51，： | 1 |
| 20 | Preexposure prophylaxis for HIV infection among African women显示文摘 | VAN DAMME L CORNELI A AHMED K | 2012 | N Engl J Meal2012，367，5： | 1 |
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