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| 1 | Sugars in peach fruit: a breeding perspective显示文摘The last decade has been characterized by a decrease in peach(Prunus persica)fruit consumption in many countries,foremost due to unsatisfactory quality.The sugar content is one of the most important quality traits perceived by consumers,and the development of novel peach cultivars with sugar-enhanced content is a primary objective of breeding programs to revert the market inertia.Nevertheless,the progress reachable through classical phenotypic selection is limited by the narrow genetic bases of peach breeding material and by the complex quantitative nature of the trait,which is deeply affected by environmental conditions and agronomical management.The development of molecular markers applicable in MAS or MAB has become an essential strategy to boost the selection efficiency.Despite the enormous advances in‘omics’sciences,providing powerful tools for plant genotyping,the identification of the genetic bases of sugar-related traits is hindered by the lack of adequate phenotyping methods that are able to address strong within-plant variability.This review provides an overview of the current knowledge of the metabolic pathways and physiological mechanisms regulating sugar accumulation in peach fruit,the main advances in phenotyping approaches and genetic background,and finally addressing new research priorities and prospective for breeders. | Marco Cirilli Daniele Bassi Angelo Ciacciulli | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | 钢包和中间包内衬耐火材料与碳钢的化学反应显示文摘在有些情况下,对钢产品内部质量的影响并不取决于生产过程中的误操作,而是低估了液态钢水与不同工序中接触到的材料间的化学反应。尤其是在铸锭生产中,这一点尤为明显。讨论了钢包与中间包内衬耐材与普碳钢间发生的化学反应。这些试验涉及高铝质、铝硅质、铝镁尖晶石质耐火材料,研究了它们在液态钢水中形成夹杂物的倾向性。试验结果表明,在钢水—耐材接触面上会产生一个富含MnO的新相,这一新相的量与二氧化硅在耐材中的活性及锰在钢液里的活性成正比。试验还表明,由液态钢水与耐火材料相互反应产生的接触面可产生新的外来夹杂物进入钢液中。试验结束后,对钢样中新的夹杂物成分做的分析表明,成分取决于耐材—钢水接触面的组成。因此,不同钢厂应该结合自身生产的钢种产品化学组成来选用耐火材料的化学成分设计。 | F Cirilli A Mazzarano M Tonelli 沈钟铭(译) 职建军(校) | 2012 | 世界钢铁2012，12，4： | 3 |
| 3 | Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances显示文摘A simple analytical high-performance liquid chromatography(HPLC) method was applied for the enantiomeric excess determination of esomeprazole((S)-OME), the enantiopure active ingredient contained in drug products, in the presence of its potential organic impurities A-E. The enantioselective separation was accomplished on the immobilized-type Chiralpak ID-3 chiral stationary phase(CSP)under reversed-phase conditions. The results were evaluated and compared with those obtained by the of fi cial enantioselective method of European Pharmacopoeia used as the reference for checking the enantiomeric excess of(S)-OME. It has been established that the use of the Chiralpak ID-3 CSP allows the determination of the enantiomeric purity of(S)-OME without any interference coming from its chiral and achiral related substances. The analytical procedure of the drug regulatory agencies based on the AGP CSP suffered instead from poor speci fi city due to overlap of the peaks pertinent to the achiral impurity A and the chiral impurity(R)-OME(impurity F). | Bruno Gallinella Rosella Ferretti Leo Zanitti Isabella Sestili Antonina Mosca Roberto Cirilli | 2016 | Journal of Pharmaceutical Analysis2016，6，2： | 2 |
| 4 | Unusual retention behavior of omeprazole and its chiral impurities B and E on the amylose tris(3-chloro-5-methylphenylcarbamate)chiral stationary phase in polar organic mode显示文摘Recent reports have demonstrated that the new commercially available immobilized-type chiral stationary phases(CSPs) containing amylose tris(3-chloro-5-methylphenylcarbamate)(ACMPC) as a selector exhibit not only an exceptionally high enantioselectivity in high-performance liquid chromatography(HPLC) but they are also applicable to a wide range of chiral analytes. Herein, we report the results obtained in the HPLC analysis of omeprazole and its impurities B and E on the ACMPC-based Chiralpak IG-3 CSP(CSP) under polar organic conditions. A systematic evaluation of the retention characteristics of the selected benzimidazole chiral probes was carried out by changing the composition of the mobile phase and the column temperature. It is worth emphasizing that the high affinity of both enantiomers of all analytes recorded in pure methanol mode dramatically decreased incorporating small volumes of either basic or acid additives in the mobile phase. Unspecified sites of the IG-3 CSP presumably involved in strong and non-stereoselective H-bonding contacts with chiral analytes are assumed responsible for the unproductive retention process. | Rosella Ferretti Leo Zanitti Adriano Casulli Roberto Cirilli | 2018 | Journal of Pharmaceutical Analysis2018，8，4： | 2 |
| 5 | ABAD directly links A beta to mitochondrial toxicity in Alzheimer's disease显示文摘 | Lustbader J W Cirilli M Lin C | 2004 | Science2004，304，5669： | 1 |
| 6 | ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease显示文摘 | Lustbader JW Cirilli M Lin C | 2004 | Science2004，304，5669： | 1 |
| 7 | ABAD directly links to mitochondrial toxicity in Alzheimer's disease显示文摘 | Lustbader JW Cirilli M Lin C | 2004 | Science2004，304，5669： | 1 |
| 8 | ABAD directly links Abeta to mitochondrial toxicity in Alzheimer′s disease显示文摘 | Lustbader JW Cirilli M Lin C | 2004 | Science2004，304，5669： | 1 |
| 9 | ABAD Directly Links Abeta to Mitochondrial Toxicity in Alzheimer's Disease显示文摘 | LUSTBADER J W CIRILLI M LIN C | 2004 | Science2004，304，5669： | 1 |
| 10 | Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts显示文摘 | Heikki Joensuu Aki Vehtari Jaakko Riihim?ki Toshirou Nishida Sonja E Steigen Peter Brabec Lukas Plank Bengt Nilsson Claudia Cirilli Chiara Braconi Andrea Bordoni Magnus K Magnusson Zdenek Linke Jozef Sufliarsky Massimo Federico Jon G Jonasson Angelo Paolo | 2012 | Lancet Oncology2012，，3： | 1 |
| 11 | ABAD directly links Abeta to mitochondrial toxicity in Alzheimer~ disease显示文摘 | Lustbader JW Cirilli M Lin C | 2004 | Science2004，304，5669： | 1 |
| 12 | Comparative study between the polysaccharide based Chiralcel OJ and Chiralcel OD CSPs in chromatographic enantioseparation of imidazole analogues of Fluoxetine and Miconazole显示文摘 | Roberto Cirilli Rosella Ferretti Bruno Gallinella | | 0，，07： | 1 |
| 13 | Biotic response to mass extinction:The lowermost Triassic microbialites,Facies显示文摘 | Baud A Cirilli S Marcoux J | 1997 | Palevol1997，36，： | 1 |
| 14 | D istinct m olecular mechanism for initiating TRAF6 signalling显示文摘 | Ye H Arron JR Lamothe B Cirilli M Kobayashi T Shevde NK Segal D Dzivenu OK Vologodskaia M Yim M Du K Singh S Pike JW D arnay BG C hoi Y W u H | | 0，，： | 1 |
| 15 | Triassic pelagic deposits of Timor: palaeogeographic and sea-level implications显示文摘 | R Martini L Zaninetti M Villeneuve J.-J Cornée L Krystyn S Cirilli P De Wever P Dumitrica A Harsolumakso | 2000 | Palaeogeography Palaeoclimatology Palaeoecology2000，，1： | 1 |
| 16 | Single-run reversed-phase HPLC method for determining sertraline content,enantiomeric purity,and related substances in drug substance and finished product显示文摘A direct enantio-,diastereo-,and chemo-selective high-performance liquid chromatographic method was developed for determining the content,enantiomeric purity,and related substances of the chiral antidepressant drug sertraline HCl in a single chromatographic run.The separation was achieved on a chiral stationary phase based on amylose tris(3-chloro-5-methylphenylcarbamate)under reversed-phase conditions.The method was optimized by evaluating the influence of the temperature and mobile phase composition on the retention and selectivity.The application of the single-run approach allowed to baseline resolve all investigated species in less than 15 min,without using buffers or tandem-coupled columns.The chromatographic method was validated according to the guidelines of the Official Medicines Control Laboratory and applied to control the content of sertraline HCl and related chiral substances in a generic antidepressant formulation. | Alessia Rosetti Rosella Ferretti Leo Zanitti Adriano Casulli Claudio Villani Roberto Cirilli | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 1 |
| 17 | 3-Acetyl-2,5-diaryl-2,3-dihydro-l, 3,4-oxadiazoles : A new scaffoldfor the selective inhibition of monxoamine oxidase B显示文摘 | Maccioni E Alcaro S Cirilli R | 2011 | J Med Chem2011，54，18： | 1 |
| 18 | Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts显示文摘 | Heikki Joensuu Aki Vehtari Jaakko Riihim?ki Toshirou Nishida Sonja E Steigen Peter Brabec Lukas Plank Bengt Nilsson Claudia Cirilli Chiara Braconi Andrea Bordoni Magnus K Magnusson Zdenek Linke Jozef Sufliarsky Massimo Federico Jon G Jonasson Angelo Paolo | 2012 | Lancet Oncology2012，，3： | 1 |
| 19 | Influence of Cu overlayer on the properties of SnO2-based gas sensors显示文摘 | Cirilli F Kaciulis S Mattogno G | 1998 | Thin Solid Films1998，315，310： | 1 |
| 20 | ABAD directiy links Abeta to mitochondrial toxicity in Alzheimer' s disease 显示文摘 | Lustbader JW Cirilli M Lin C | 2004 | Science2004，304，5669： | 1 |
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