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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion显示文摘Intestinal ischemia is a frequently observed phenomenon. Morbidity and mortality rates are extraordinarily high and did not improve over the past decades. This is in part attributable to limited knowledge on the pathophysiology of intestinal ischemia-reperfusion(IR) in man, the paucity in preventive and/or therapeutic options and the lack of early diagnostic markers for intestinal ischemia. To improve our knowledge and solve clinically important questions regarding intestinal IR, we developed a human experimental intestinal IR model. With this model, we were able to gain insight into the mechanisms that allow the human gut to withstand short periods of IR without the development of severe inflammatory responses. The purpose of this review is to overview the most relevant recent advances in our understanding of the pathophysiology of human intestinal IR, as well as the(potential) future clinical implications. | Joep Grootjans Kaatje Lenaerts Wim A Buurman Cornelis HC Dejong Joep PM Derikx | 2016 | World Journal of Gastroenterology2016，22，9： | 11 |
| 3 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 4 | Human small intestine is capable of restoring barrier function after short ischemic periods显示文摘AIM To assess intestinal barrier function during human intestinal ischemia and reperfusion(IR).METHODS In a human experimental model,6 cm of jejunum was selectively exposed to 30 min of ischemia(I) followed by 30 and 120 min of reperfusion(R). A sham procedure was also performed. Blood and tissue was sampled at all-time points. Functional barrier function was assessed using dual-sugar absorption tests with lactulose(L) and rhamnose(R). Plasma concentrations of citrulline,an amino acid described as marker for enterocyte function were measured as marker of metabolic enterocytes restoration. Damage to the epithelial lining was assessed by immunohistochemistry for tight junctions( TJs),by plasma marker for enterocytes damage(I-FABP) and analyzed by electron microscopy(EM) using lanthanum nitrate as an electrondense marker.RESULTS Plasma L/R ratio's were significantly increased after 30 min of ischemia(30 I) followed by 30 min of reperfusion(30 R) compared to control(0.75 ± 0.10 vs 0.20 ± 0.09,P < 0.05). At 120 min of reperfusion(120 R),ratio's normalized(0.17 ± 0.06) and were not significantly different from control. Plasma levels of I-FABP correlated with plasma L/R ratios measured at the same time points(correlation: 0.467,P < 0.01). TJs staining shows distortion of staining at 30 I. An intact lining of TJs was again observed at 30 I120 R. Electron microscopy analysis revealed disrupted TJs after 30 I with paracellular leakage of lanthanum nitrate,which restored after 30 I120 R. Furthermore,citrulline concentrations closely paralleled the histological perturbations during intestinal IR.CONCLUSION This study directly correlates histological data with intestinal permeability tests,revealing that the human gut has the ability of to withstand short episodes of ischemia,with morphological and functional recovery of the intestinal barrier within 120 min of reperfusion. | Dirk HSM Schellekens Inca HR Hundscheid Claire AJI Leenarts Joep Grootjans Kaatje Lenaerts Wim A Buurman Cornelis HC Dejong Joep PM Derikx | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 5 | The Virulence Plasmid of Yersinia, an Antihost Genome 显示文摘 | Cornelis GR Boland A Boyd AP | 1998 | Microbiology and Molecular Biology Reviews1998，62，： | 4 |
| 6 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 7 | Circadian heart rate and blood pressure variability considered for research and patient care 显示文摘 | Singh RB Corne lissen G Weydahl A | 2003 | Int J Cardiol2003，87，1： | 1 |
| 8 | Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium)显示文摘 | J Nouwen C Cornelis R De Fré M Wevers P Viaene C Mensink J Patyn L Verschaeve R Hooghe A Maes M Collier G Schoeters R Van Cleuvenbergen P Geuzens | 2001 | Chemosphere2001，，4： | 1 |
| 9 | Preexposure prophylaxis for HIV infection among African women显示文摘 | Van Damme L Corneli A Ahmed K | 2012 | N Engl J Med2012，367，5： | 1 |
| 10 | Pharmacokinetics,Safety,and Efficacy of Posaconazole in Patients with Persistent Febrile Neutropenia or Refractory Invasive Fungal Infection 显示文摘 | AJ Ullmann OA Cornely A Burchardt | 2006 | Antimicrob Agents Chemother2006，50，2： | 1 |
| 11 | Platelet--poor plasma serotonin in normal and preeclamptic pregnancy显示文摘 | Cornelis M Gustaaf A | 1993 | Clin Chem1993，39，： | 1 |
| 12 | Chromosomal relationships among cultivars of Citrus reticulata Blanco, its hybrids and related species显示文摘 | M. T. M. N. Cornélio A. R. S. Figueir?a K. G. B. Santos R. Carvalho W. S. Soares Filho M. Guerra | 2003 | Plant Systematics and Evolution (-)2003，，1： | 1 |
| 13 | Murine coronavirus with an extended host range uses heparan sulfate as an entry receptor显示文摘 | Cornelis A M Haan C A Li Z | | 0，，22： | 1 |
| 14 | In vivo pectoralis muscle force-length behavior during level flight in pigeons(Columba livia)显示文摘 | Biewener A A Corning W R Tobalske B W | 1998 | Journal of Experimental Biology1998，201，12： | 1 |
| 15 | Synergy and self - organization in the evolution of complex systems 显示文摘 | CORNING P A | 1995 | Systems Research1995，，6： | 1 |
| 16 | Adequate margins for Random setup uncertainties in head-an-neck IMRT显示文摘 | Eleftheria A Arjan B Cornelis P J | 2005 | Int J Ra- diat Oncol Biol Phys2005，61，3： | 1 |
| 17 | Moderate-to-heavy alcohol intake is associated with differences in synchronization of brain activity during rest and mental rehearsal显示文摘 | Eveline A de Bruin Cornelis J Stamb Suzanne Bijl | 2006 | International Journal of Psychophysiology2006，60，3： | 1 |
| 18 | Effects of exenatide on measures ofβ-cell function after 3 years in metformin-treated patients with type 2 diabetes显示文摘 | Bunek MC Cornér A Eliasson B | 2011 | Diabetes Care2011，34，9： | 1 |
| 19 | The Synergism Hypothesis:On the concept of synergy and its role in the evolution of complex systems显示文摘 | Corning P A | 1998 | Journal of Social and Evolutionary Systems1998，21，2： | 1 |
| 20 | Long memory options:LM evidence and simulations显示文摘 | Sut thisit Jamdee Cornelis A Los | 2007 | Research in International Business and Finance2007，21，： | 1 |
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