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| 1 | Exercise guidelines for gestational diabetes mellitus显示文摘The prevalence of gestational diabetes mellitus(GDM)is increasing worldwide.This disease has many detrimental consequences for the woman,the unborn foetus and child.The management of GDM aims to mediate the effects of hyperglycaemia by controlling blood glucose levels.Along with pharmacology and dietary interventions,exercise has a powerful potential to assist with blood glucose control.Due to the uncertainty of risks and benefits of exercise during pregnancy,women tend to avoid exercise.However,under adequate supervision exercise is both safe and beneficial in the treatment of GDM.Therefore it is vital that exercise is incorporated into the continuum of care for women with GDM.Medical doctors should be able to refer to competently informed exercise professionals to aid in GDM treatment.It is important that exercise treatment is informed by research.Hence,the development of evidence-based guidelines is important to inform practice.Currently there are no guidelines for exercise in GDM.This review aims to assess the efficacy of exercise for the management of GDM in order to establish an exercise prescription guideline specific to the condition.It is recommended that women with GDM should do both aerobic and resistance exercise at a moderate intensity,a minimum of three times a week for 30-60min each time. | Cliantha Padayachee Jeff S Coombes | 2015 | World Journal of Diabetes2015，6，8： | 31 |
| 2 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 3 | 重症监护中生命维持治疗撤除前和撤除时以家庭为中心的护理:澳大利亚重症监护的护理人员与患者家属分享信息的调研显示文摘背景:重症监护室为患者提供临终关怀时,以家庭为中心的护理的核心要素是与家属的信息共享。但对在这种环境下共享的信息仍知之甚少。目的 :在生命维持治疗准备撤除和撤除时,确认重症监护室护理人员最常提供给患者家属的信息。方法 :2015年5月,澳大利亚和新西兰的重症监护室护理人员受邀完成'治疗撤除的家庭准备'问卷。数据分析包括进行描述性统计,以确定最常和最少与家属分享的信息面。人口学统计资料的交叉列表用于探测数据的相关性。结果:159名重症监护室护理人员的回答显示,在生命维持治疗准备撤除和撤除时,最常与家属分享的是家庭的情感关怀和支持的相关信息。死亡过程中,患者身体状况及相关的生理改变等信息提供的频率,存在较大变异。人口学变量(性别、护理经验和重症护理经验)与某些最常和最少分享信息之间存在相关性(P<0.05)。结论 :临终关怀期间,由重症监护室护理人员给予的信息分享反映了以家庭为中心的护理方法,涉及关于家庭的情感关怀和支持等至关重要的信息。本研究的发现,为此时发展干预措施,以改善实践和支持护理人员与患者家属沟通交流,提供了一个有用的框架。 | Kristen Ranse Melissa Bloomer Maureen Coombs Ruth Endacott | 2017 | 中国护理管理2017，17，6： | 6 |
| 4 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 5 | Triple-negative breast cancer: therapeutic options显示文摘 | Susan Cleator Wolfgang Heller R Charles Coombes | 2007 | Lancet Oncology2007，，3： | 2 |
| 6 | 类危机:公开管理对危机预防带来的挑战显示文摘社交媒体常常被认为是发现危机风险的关键工具。当这些危机风险出现在网络上,人们往往会将其与真正的危机进行混淆,因此,我们提出'类危机'这一概念。'类'是'像'的意思,'类危机'即是一个像是危机事件的信号。它看起来像是一个危机事件,需要组织机构进行应对。但实际上,应对'类危机'并不需要召集公关小组,开启应急预案。本文将详细说明提出'类危机'的意义,如何去评估它们的潜在风险以及应对的策略,并对这些策略的效用进行评估。 | 孟翔飞 王雪 杨楠 W.Timothy Coombs J.Sherry Holladay | 2017 | 辽宁公安司法管理干部学院学报2017，0，2： | 2 |
| 7 | Intercultural teaching and learning strategies for global citizens: a Chinese EFL perspective显示文摘 | Hongqin Zhao Steven Coombs | 2012 | Teaching in Higher Education2012，，3： | 2 |
| 8 | Resveratrol Does Not Benefit Patients with Non-alcoholic Fatty Liver Disease显示文摘 | Veronique S. Chachay Graeme A. Macdonald Jennifer H. Martin Jonathan P. Whitehead Trisha M. O’Moore-Sullivan Paul Lee Michael Franklin Kerenaftali Klein Paul J. Taylor Maree Ferguson Jeff S. Coombes Gethin P. Thomas Gary J. Cowin Carl M.J. Kirkpatrick Joh | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 9 | Serum p24 antigen level as an intermediate end point in clinical trials of zidovudine in people infected with human immunodeficiency virus type 1显示文摘 | DeGruttola V Beckett LA Coombs RW | 1994 | J Infect Dis1994，169，4： | 2 |
| 10 | Attribution Theory as a guide for post-crisis communication research显示文摘 | W. Timothy Coombs | 2007 | Public Relations Review2007，，2： | 2 |
| 11 | Primary malignant neoplasms of the spleen显示文摘 | Das Gupta T Coombes B Brasfield RD | 1965 | Surg Gynecol Obstet1965，120，5： | 1 |
| 12 | Nano-network eletronic conduction in iron and nickel olivine phosphates显示文摘 | Herle P S Ellis B Coombs N | 2004 | Nat Mater2004，3，： | 1 |
| 13 | Triple-negative breast cancer: therapeutic options 显示文摘 | Cleator S Heller W Coombes RC | 2007 | Lancet Oncol2007，8，3： | 1 |
| 14 | Leishmaniamexicana cysteine proteinase-deficient mutants have attenua-ted virulence for mice and potentiate a Th1response显示文摘 | Alexander J Coombs G H Mottram J C | 1998 | J Im-munol1998，161，： | 1 |
| 15 | Electroactive mesoporous ynria stabilized zirconia containing platinmn or nickel oxide nanoclusters: a new class of solid oxide tuel cell electrode materials 显示文摘 | Mamak M Coombs N Ozin G A | 2001 | Ad- vanced Functional Materials2001，11，1： | 1 |
| 16 | Introducing microcells into macrocellular networks:a case study显示文摘 | R Coombs R Steele | 1999 | IEEE Transactions on Communications1999，47，4： | 1 |
| 17 | Preoperative beta - blocker use and mortality and morbidity following CABG surgery in North American显示文摘 | Ferguson TB JR Coombs LP Peterson ED | 2002 | JAMA2002，287，： | 1 |
| 18 | Film blowing of line- ar low-density polyethylene blended with a novel hyperbranched polymer processing aid显示文摘 | Hong Y Coombs S J Cooper-White J J | 2000 | Polymer2000，41，21： | 1 |
| 19 | Advanced nursing roles in critical care:anatural or forced evolution显示文摘 | Coombs M Chaboyer W Sole ML | 2007 | Journal of Professional Nursing2007，23，2： | 1 |
| 20 | Effect of alkali treatment on intake and digestion of barley straw by beef steers显示文摘 | COOMBE J B DINUIS D A WHEELER W E | 1979 | Journal of Animal Science1979，49，1： | 1 |
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