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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Survivin expression in chronic myeloid leukemia显示文摘 | CONTE E STAGNO F GUGLIELMO P | 2005 | Cancer Lett2005，225，1： | 1 |
| 3 | Attach- ment of single-wall carbon nanotubes on platinum surfaces by self-as- sembling techniques显示文摘 | ROSARIO-CASTRO B CONT S E P REZ-DAVIS M | 2005 | Rev Adv Mater Sei2005，10，： | 1 |
| 4 | Determination of gecemin and methylisoborneol in catfish tissue(Ictalurus punctatus)by microwave-assisted distillation-solid phase adsorbent trapping显示文摘 | Conte E D Shen C Peter W P | 1996 | J Agric Food Chem1996，44，： | 1 |
| 5 | Long-term follow-up of neuroblastoma-associated op-soclonus-myoclonus-ataxia syndrome显示文摘 | De Grandis E Parodi S Conte M Angelini P Battaglia F Gan-dolfo C | 2009 | Neuropediatrics2009，40，3： | 1 |
| 6 | Determination of methylisobomeol in channel catfish pond water by solid phase extraction followed by gas chromatography-mass spectrometry显示文摘 | Conte E Conway S Miller D Perschbacher P | | 0，，09： | 1 |
| 7 | Procedural Distress in Children with Cancer: Self-Report, Behavioral Observations, and Physiological Parameters 显示文摘 | WALCO G A CONTE P M LABAY L E | 2005 | Clinical Journal of Pain2005，21，6： | 1 |
| 8 | Determination of methylsiobomeol in Channel Catfish pond water by solid phase extraction followed by gas chromatography-mass spectrometry显示文摘 | Conte E D Conway S C Miller D W Perschbacher P W | | 0，，09： | 1 |
| 9 | Oral vinorelbine: role in the management of metastatic breast cancer显示文摘 | Aapro MS Conte P Esteban E | 2007 | Drugs2007，67，5： | 1 |
| 10 | Stem cell protection mechanisms in planarians:the role of some heat shock genes显示文摘 | Isolani M E Conte M Deri P | 2012 | International Journal of Developmental Biology2012，56，56： | 1 |
| 11 | Acceleration tracking performance of the UCSD - NEES shake table显示文摘 | LUCO J E OZCELIK O CONTE J P | 2010 | ASCE Journal of Structural Engineering2010，136，5： | 1 |
| 12 | Reduced heterogeneity of a lignite humic acid by preparative HPSEC following interaction with an organic acid: Characterization of size-separates by Pyr-GC-MS and 'H-NMR spectroscopy 显示文摘 | Piccolo A Conte P Trivellone E | 2002 | Environ Sci Technol2002，36，1： | 1 |
| 13 | Characterization of hspgenes in planarian stem cells显示文摘 | Conte M Deri P Isolani M E | 2010 | Belgian Journal of Zoology2010，140，3： | 1 |
| 14 | Phase Ⅱ/Ⅲ weekly nab-paclitaxel plus gemcitabine or carboplatin versus gemcitabine/carboplatin as first-line treatment of patients with metastatic triple-negative breast cancer (the tnAcity study): study protocol for a randomized controlled trial显示文摘 | Yardley D A Brufsky A Coleman R E Conte P F Cortes J Glück S | 2015 | Trials2015，16，： | 1 |
| 15 | Germline mutations of the BRCA1-associated ring domain (BARD1) gene in breast and breast/ovarian families negative for BRCA1 and BRCA2 alterations显示文摘 | Ghimenti C Sensi E Presciuttini S Brunetti IM Conte P Bevilacqua G Caligo MA | | 0，，03： | 1 |
| 16 | Effect of neonatal treatment with monosodium glutamate on the secretion of alpha - MSH, beta - endorphin and ACTH in the rat 显示文摘 | Conte - Devolx B Giraud P Castanas E | 1981 | Neuroendoerinology1981，33，4： | 1 |
| 17 | A mortalin-like gene is crucial for planarian stem cell viability显示文摘 | Conte M Deri P Isolani M E | 2009 | Developmental Biology2009，334，1： | 1 |
| 18 | Three-dimensional organization of the hepatic artery terminal branches:a scanning electron microscopic study of vascular corrosion casts of rat liver显示文摘 | Pannarale L Onori P Borghese F Conte D Gaudio E | 2007 | Ital J Anat Embryol2007，112，： | 1 |
| 19 | Experimental characterization, modeling and identification of the NEES -UCSD shake table mechanical system 显示文摘 | Ozeelik O Luco J E Conte J P | 2008 | Earthquake Engineering & Structural Dynamics2008，37，2： | 1 |
| 20 | Bats are a major natural reservoir for hepaeiviruses and pegiviruses显示文摘 | Quan P L Firth C Conte J M Williams S H Zam- brana-Torrelio C M Anthony S J Ellison J A Gilbert A T Kuzmin I V Niezgoda M Osinubi M O Re-cuenco S Markotter W Breiman R F Kalemba L Malekani J Lindblade K A Rostal M K Ojeda-Flores R Suzan G Davis L B Blau D M Ogunkoya A B Alvarez Castillo D A Moran D Ngam S Akaibe D Agwanda B Briese T Epstein J H Daszak P Rup- precht C E Holmes E C Lipkin W I | 2013 | PNAS2013，110，20： | 1 |
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