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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Molecular characterization of Cryptosporidium isolates from humans and other animals using random amplified polymorphic DNA analysis显示文摘 | Morgan UM Constantine CC O'Donoghue P | 1995 | Am J rrop Med Hyg1995，52，6： | 1 |
| 3 | Molecular characterization of Cryptosporidium isolates from humans and other animals using random amplified polymorphic DNA analysis 显示文摘 | Morgan UM Constantine CC O'Donoghue P | 1995 | Am J Trop Med Hyg1995，52，6： | 1 |
| 4 | Immunohisto- chemical detection of P- glycoprotein in endometrial adenocarcinoma 显示文摘 | Monteagado O Merino HJ | 1991 | Am J Pathol1991，138，： | 1 |
| 5 | Molecular characterization of Cryptospo-ridium isolates from humans and other animals using random amplifie polymorphic DNA an-alysis显示文摘 | Morgan UM Constantine CC O'Donoghue P | 1995 | Am J Trop Med Hyg1995，52，6： | 1 |
| 6 | Long-term survival of patients with idiopathic inflammatory myopathies according to clinical features:a longitudinal study of 162 cases显示文摘 | Dank(o) K Ponyi A Constantin T | | 0，，： | 1 |
| 7 | A Novel Approach in Cinnamic Acid Synthesis: Direct Synthesis of Cinnamic Acids from Aromatic Aldehydes and Aliphatic Carboxylic Acids in the Presence of Boron Tribromide显示文摘 | Constantin I C Fulga T Marioara O | 2005 | Molecules2005，10，： | 1 |
| 8 | lmage-guided multipolar radiofrequency ablation of liver tumours: initial clinical results显示文摘 | Terraz S Constantin O Majno PE | 2007 | Eur Radiol2007，17，9： | 1 |
| 9 | Immunohistochemical detection of P-glycoprntein in endometrial adenocarcinoma显示文摘 | Constantine A Monteagado O Merino H J | 1991 | Am J Pathol1991，138，4： | 1 |
| 10 | The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy显示文摘 | Zahi Mitri Tina Constantine Ruth O’Regan Nabil F. Saba | 2012 | Chemotherapy Research and Practice2012，，： | 1 |
| 11 | Experimental study of FPS system in bridge seismic isolation 显示文摘 | T sopelas P M C Constantinou Kim Y S O kamo to S | 1996 | Earthquake Engineering and Structural Dynamics1996，25，： | 1 |
| 12 | Immunohistochemical detection of P-glyco protein in endometrial adrenocarcinoma 显示文摘 | Constantine A Monteagado O | 1991 | Am J Pathol1991，138，： | 1 |
| 13 | Molecular characterization of Cryptosporidium isolates from humans and other animals using random amplified polymorphic DNA analysis显示文摘 | Morgan UM Constantine CC O'Donoghue P | 1995 | Am J Trop Med Hyg1995，52，6： | 1 |
| 14 | Immunohistochemical detection of P-glycoprotein in endometrial adenocarcinoma显示文摘 | Constantine A Monteagado O Merino HJ | 1991 | Am J Pathol1991，138，4： | 1 |
| 15 | Attentional bias,inhibitory control and acute stress in current and former opiate addicts显示文摘 | Constantinou N Morgan C.J Battistella S O'Ryan D Davis P & Curran H.V | | 0，，01： | 1 |
| 16 | Quantitative imaging biomarkers: A review of statistical methods for technical performance assessment显示文摘 | Raunig David L McShane Lisa M Pennello Gene Gatsonis Constantine Carson Paul L Voyvodic James T Wahl Richard L Kurland Brenda F Schwarz Adam J G?nen Mithat Zahlmann Gudrun Kondratovich Marina V O’Donnell Kevin Petrick Nicholas Cole Patricia | 2015 | Statistical Methods in Medical Research2015，，： | 1 |
| 17 | Therapeutical considerations in associated atrial fibrillation and heart failure显示文摘 | Mitu O Mitu F Constantin S | 2014 | Rev Med Chir Soc Med Nat Iasi2014，118，3： | 1 |
| 18 | Determining modes and fractal dimension of turbulent flows 显示文摘 | Constantin P Foias C Manley O | 1985 | J Fluid Mech1985，150，： | 1 |
| 19 | Estimation of the acentric factor and the liquid molar volume at 298 K using a new group contribution method显示文摘 | Constantinou L Gani R O'Connel P | 1995 | Fluid Phase Equilibria1995，103，1： | 1 |
| 20 | Managing academic internationalization: a culture-based ap- proach 显示文摘 | BURDUSEL Eva-Nicoleta CAMELIA O CONSTANTIN O | 2014 | management of sustainable development2014，6，2： | 1 |
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