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| 1 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 2 | Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: Effect of bombesin and neurotensin显示文摘瞄准:调查试验性的妨碍的黄疸和外长的 bombesin 和 neurotensin (NT )(BBS ) 的影响紧密的连接(TJ ) 的表示上的管理在老鼠的肠上皮的蛋白质 claudin-4。方法:四十只男 Wistar 老鼠随机被划分成五个组:我 = 控制, II = 假冒操作, III = 胆汁管结扎(BDL ) , IV = BDL+BBS (30 microg/kg 每 d ) , V = BDL+NT (300 microg/kg 每 d ) 。在 d 的实验的结束 10,内毒素在门和大动脉的血被测量。终端回肠的织物节组织学地被检验并且免疫组织化学地为在肠上皮的 claudin-4 表示的评估。结果:妨碍的黄疸导致了重要的门和大动脉的 endotoxemia 表明的肠的障碍失败。Claudin-4 表示显著地被增加在上面在 jaundiced 老鼠的第三根绒毛并且一起来它的侧面的分发的规定被注意。BBS 或 NT 的管理恢复了 claudin-4 表示到控制状态并且显著地减少了门和大动脉的 endotoxemia。结论:在肠上皮的试验性的妨碍的黄疸增加 claudin-4 表示,它可以是贡献粘膜障碍的混乱的一个关键因素。毁坏规章的肽 BBS, NT 能阻止这扇改变和还原剂门和全身的 endotoxemia。 | Stelios F Assimakopoulos Constantine E Vagianos Aristides S Charonis Ilias H Alexandris Iris Spiliopoulou Konstantinos C Thomopoulos Vassiliki N Nikolopoulou Chrisoula D Scopa | 2006 | World Journal of Gastroenterology2006，12，21： | 21 |
| 3 | Brain-lung crosstalk: Implications for neurocritical care patients显示文摘Major pulmonary disorders may occur after brain injuries as ventilator-associated pneumonia, acute respiratory distress syndrome or neurogenic pulmonary edema. They are key points for the management of brain-injured patients because respiratory failure and mechanical ventilation seem to be a risk factor for increased mortality, poor neurological outcome and longer intensive care unit or hospital length of stay. Brain and lung strongly interact via complex pathways from the brain to the lung but also from the lung to the brain. Several hypotheses have been proposed with a particular interest for the recently described 'double hit' model. Ventilator setting in brain-injured patients with lung injuries has been poorly studied and intensivists are often fearful to use some parts of protective ventilation in patients with brain injury. This review aims to describe the epidemiology and pathophysiology of lung injuries in brain-injured patients, but also the impact of different modalities of mechanical ventilation on the brain in the context of acute brain injury. | Ségolène Mrozek Jean-Michel Constantin Thomas Geeraerts | 2015 | World Journal of Critical Care Medicine2015，4，3： | 20 |
| 4 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 5 | High-energy hybrid femtosecond laser system demonstrating 2×10 PW capability显示文摘We report on a two-arm hybrid high-power laser system(HPLS)able to deliver 2×10 PW femtosecond pulses,developed at the Bucharest-Magurele Extreme Light Infrastructure Nuclear Physics(ELI-NP)Facility.A hybrid frontend(FE)based on a Ti:sapphire chirped pulse amplifier and a picosecond optical parametric chirped pulse amplifier based on beta barium borate(BBO)crystals,with a cross-polarized wave(XPW)filter in between,has been developed.It delivers 10 mJ laser pulses,at 10 Hz repetition rate,with more than 70 nm spectral bandwidth and high-intensity contrast,in the range of 1013:1.The high-energy Ti:sapphire amplifier stages of both arms were seeded from this common FE.The final high-energy amplifier,equipped with a 200 mm diameter Ti:sapphire crystal,has been pumped by six 100 J nanosecond frequency doubled Nd:glass lasers,at 1 pulse/min repetition rate.More than 300 J output pulse energy has been obtained by pumping with only 80%of the whole 600 J available pump energy.The compressor has a transmission efficiency of 74%and an output pulse duration of 22.7 fs was measured,thus demonstrating that the dual-arm HPLS has the capacity to generate 10 PW peak power femtosecond pulses.The reported results represent the cornerstone of the ELI-NP 2×10 PW femtosecond laser facility,devoted to fundamental and applied nuclear physics research. | François Lureau Guillaume Matras Olivier Chalus Christophe Derycke Thomas Morbieu Christophe Radier Olivier Casagrande Sébastien Laux Sandrine Ricaud Gilles Rey Alain Pellegrina Caroline Richard Laurent Boudjemaa Christophe Simon-Boisson Andrei Baleanu Romeo Banici Andrei Gradinariu Constantin Caldararu Bertrand De Boisdeffre Petru Ghenuche Andrei Naziru Georgios Kolliopoulos Liviu Neagu Razvan Dabu Ioan Dancus Daniel Ursescu | 2020 | High Power Laser Science and Engineering2020，8，4： | 4 |
| 6 | 七氟烷、地氟烷或丙泊酚麻醉术后疼痛和镇痛药需求量的比较显示文摘背景全身麻醉药可产生伤害反应从而影响手术后疼痛,在一些手术后疼痛的研究中,均没有考虑全麻药对镇痛药需要量的影响,仅有最近一项研究显示丙泊酚麻醉的手术后镇痛效果比异氟烷麻醉好。方法前瞻性、随机、双盲研究,记录在七氰烷、地氟烷或丙泊酚麻醉下行腹式子宫切除术或子宫肌瘤切除手术患者手术后2、4、8、和24小时吗啡的需要量和疼痛评分(疼痛视觉模拟评分,VAS),手术中维持BIS35~45。同时记录患者送至麻醉监护室时的疼痛评分。结果3组患者手术后2、4、8或24小时,吗啡累积消耗量无差异(P=0.50)。手术后24小时内吗啡消耗量:七氟烷组28±13.8mg;地氟垸组25±11.7mg;丙泊酚组27±16.1mg。疼痛评分在患者转运至麻醉监护室即刻、手术后2、4、8和24小时,分别在静息及咳嗽状态下评估,显示3组间无差异(静息时P=0.40、0.39、0.50、0.47、0.06;咳嗽后P=0.67、0.45、0,22、0.26、0.29).结论手术后24小时吗啡消耗量和手术后疼痛情况在七氟烷、地氟烷或丙泊酚3组间差异无显著性。 | Argyro Fas s oulaki Aikaterini Melemeni Anteia Paraskeva Ioanna Siafaka Constantine Sarantopoulos 宋村笛(译) 李士通(校) | 2009 | 麻醉与镇痛2009，，6： | 2 |
| 7 | Correlation between the proportion of breast volume involved by locally advanced tumors and invasion of the skin and posterior structures显示文摘AIM: To evaluate any differences between the percentages of involved breast volume, pathologic attributes,and tumor marker expression of T3 and T4a-c tumors in locally advanced breast cancers(BC).METHODS: All patients with T3 N > 0 and T4a-c BC without evidence of distant metastasis(M0), presenting to the Breast Clinic from 1980 to 2010, were examinedto determine whether their BC's involved ≥ 50% of their breast volumes, defined by gross replacement of at least one hemisphere. Core needle biopsy or postmastectomy specimens from tumors involving a known percent of breast volume were evaluated for:(1)pathological grades and lympho-vascular invasion(LVI);(2) hormone receptor(ER/PR) expression > 0; and(3)epidermoid growth factor 2(her2) over-expression(3+)by immune-histochemical staining or fluorescent in situ hybridization.RESULTS: The data base included 98 patients with T3N> 0 M0 and 120 with T4a-c, any N disease, M0 disease. T3 tumor masses involved 50% or more of the breast in 23/98(24%), and T4a-c tumors 65/120(54%)(P < 0.001). Only 1% of T3 tumors and 23% of T4a-c tumors presented with total breast replacement. There were no significant differences between the pathological attributes and marker expression of the T3 and T4a-c tumors.CONCLUSION: These data suggest that erosion of the overlying skin or underlying chest wall by some BC may be due to neglect and delay, rather than inherent biological aggressiveness. | Parastoo B Dahi Komal P Dhiran Constantine A Axiotis Jeremy Weedon Mahmoud El-Tamer Gurinder Sidhu Albert S Braverman | 2012 | World Journal of Clinical Oncology2012，3，3： | 2 |
| 8 | Semaphorin Sema3F has a repulsing activity on breast cancer cells and inhibits E cadherin-mediated cell adhesion 显示文摘 | Nasarre P Kusy S Constantin B | 2005 | Neoplasia2005，7，2： | 1 |
| 9 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post-column indirect fluorescence detection 显示文摘 | CONSTANTINE D S CONSTANTINA N K CHRISTOS G N | 2003 | Journal of Chromatography A2003，1002，： | 1 |
| 10 | Extration,separation,and detection methods for phe-nolic acids and flavonoids显示文摘 | CONSTANTINE D S | 2007 | J Sep Sci2007，30，： | 1 |
| 11 | Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherinmediated cell adhesion显示文摘 | Nasarre P Kusy S Constantin B | 2005 | Neoplasia2005，7，2： | 1 |
| 12 | Role of MRI in clinical cardiology 显示文摘 | Constantine G Shan K Flamm S D | 2004 | Lancet2004，363，9427： | 1 |
| 13 | Sesmic Isolation Retrofit of Large Historic Buildings显示文摘 | Mokha A S Amin N Constantinou M C | 1996 | Journal of structure engineering ASCE1996，122，3： | 1 |
| 14 | Interventricular and intrav- entrieular dyssynehrony are common in heart failure patients,regardless of QRS duration显示文摘 | Ghio S Constantin C Klersy C | 2004 | Eur Heart J2004，25，7： | 1 |
| 15 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post-column indirect fluorescence de- tection显示文摘 | CONSTANTINE D S CONSTANTINA N K CHRISTOS G N | 2003 | J Chromatogr A2003，100，2： | 1 |
| 16 | Experimental Study of FPS System in Bridge Seismic Isolation显示文摘 | Tsopelas P Constantinou M C Kim Y S | 1996 | Earthquake Engineering and Structural Dynamics1996，25，： | 1 |
| 17 | Seismic isolation retrofit of large historic building显示文摘 | Mokha A S Amin N Constantinou M C Zayas V | 1996 | Journal of Structural Engineering ASCE1996，122，3： | 1 |
| 18 | Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration显示文摘 | Ghio S Constantin C Klersy C | 2004 | Eur Heart J2004，25，7： | 1 |
| 19 | Experimental study of friction pendulum system isolation system显示文摘 | Mokha A S Constantinou M C Reinhorn A M Zayas V | 1991 | Journal of Structural Engineering ASCE1991，117，4： | 1 |
| 20 | Inverse scattering transform for the Camassa?Holm equation显示文摘 | Constantin A Gerdjikov V S Ivanov R 1 | 2006 | Inverse Problems2006，22，： | 1 |
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