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| 1 | Postoperative ileus: Impact of pharmacological treatment,laparoscopic surgery and enhanced recovery pathways显示文摘Almost all patients develop postoperative ileus (POI) after abdominal surgery.POI represents the single largest factor influencing length of stay (LOS) after bowel resection,and has great implications for patients and resource utilization in health care.New methods to treat and decrease the length of POI are therefore of great importance.During the past decade,a substantial amount of research has been performed evaluating POI,and great progress has been made in our understanding and treatment of POI.Laparoscopic procedures,enhanced recovery pathways and pharmacologic treatment have been introduced.Each factor has substantially contributed to decreasing the length of POI and thus LOS after bowel resection.This editorial outlines resource utilization of POI,normal physiology of gut motility and pathogenesis of POI.Pharmacological treatment,fast track protocols and laparoscopic surgery can each have significant impact on pathways causing POI.The optimal integration of these treatment options continues to be assessed in prospective studies. | Knut Magne Augestad Conor P Delaney | 2010 | World Journal of Gastroenterology2010，16，17： | 33 |
| 2 | Surgical treatment for rectal cancer:An international perspective on what the medical gastroenterologist needs to know显示文摘Rectal cancer accounts for one third of all colorectal cancers.The age adjusted death rates from colorectal cancer have declined over recent decades due to a combination of colorectal cancer screening,improved diagnostic tests,improved standardized surgical technique,improved medical support,neoadjuvant chemotherapies and radiation treatment or combinations of these.Because of complex treatment algorithms,use of multidisciplinary teams in the management of rectal cancer patients has also been popularized.Medical gastroenterologists performing colonoscopies are frequently the first health care provider to raise the suspicion of a rectal cancer.Although the diagnosis depends on histological confirmation,the endoscopic presentation is almost diagnostic in many cases.In order to meet the patient's immediate needs for information,it is important that the endoscopist has knowledge about the investigations and treatment options that will be required for their patient.The aim of this paper is to describe the modern preoperative investigations and operative procedures commonly offered to rectal cancer patients taking into account perspectives of three colorectal surgeons,practicing in the USA,Europe and Asia. | Rolv-Ole Lindsetmo Yong-Geul Joh Conor P Delaney | 2008 | World Journal of Gastroenterology2008，14，21： | 13 |
| 3 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 4 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 5 | Pharmacological management of post- operative ileus显示文摘 | Farhad G Jonah JS Conor P | 2009 | Can J Surg2009，52，2： | 1 |
| 6 | Inhibition of LPS- induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist显示文摘 | Leaker BR Barnes P] O' Conor B | 2013 | Respir Res2013，14，： | 1 |
| 7 | Alvimopan显示文摘 | Conor P D Urea Y Peter K | 2008 | Nature Reviews Drug Discovery2008，，7： | 1 |
| 8 | Modified silica-containing matrices towards the MALDI-TOF-MS detection of small molecules 显示文摘 | Conor P M Sreenivasa R A Waldemar G | 2011 | International Journal of Mass Spectrometry Journal2011，308，23： | 1 |
| 9 | Alvimopan,for postoperative ileus following bowel resection显示文摘 | Conor P Delaney M D Ph D | 2007 | Ann Surgery2007，245，3： | 1 |
| 10 | Randomized controlled trial comparing the controlled rehabilitation with early ambulation and diet pathway versus the controlled rehabilitation with early ambulation and diet with preemptive epidural anesthesia/analgesia after laparotomy and intestinal resection显示文摘 | Massarat Zutshi Conor P Delaney M | 2005 | Am J Surg2005，189，3： | 1 |
| 11 | Survival of Low-pH Stress by Escherichia coli O157:H7:correlation between Alterations in the Cell Envelope and Increased Acid Tolerance显示文摘 | Lynn O Conor P | 1999 | Applied and Environmental Microbiology1999，65，： | 1 |
| 12 | Pharmacological man- agement of postoperative ileus显示文摘 | Farhad Z Jonah JS Conor P | 2009 | Can J Surg2009，52，2： | 1 |
| 13 | PROTEASES IN PARASITIC DISEASES显示文摘 | James H. McKerrow Conor Caffrey Ben Kelly P’ng Loke Mohammed Sajid | 2006 | Annual Review of Pathology: Mechanisms of Disease2006，，： | 1 |
| 14 | Radiotherapy for muscle-invasive carcinoma of the bladder: results of a randomized trial comparing conventional whole bladder with dose-escalated partial bladder radiotherapy显示文摘 | Richard A Cowan Catherine A McBain W.David J Ryder James P Wylie John P Logue Sandra L Turner Johannes Van Der Voet Conor D Collins Vincent S Khoo Graham R Read | 2004 | International Journal of Radiation Oncology Biology Physics2004，，1： | 1 |
| 15 | Confirmatory analysis of malachite green, leucomalachite green crystal violet and leucocrystal violet in salmon by liquid chromatography-tandem mass spectrometry显示文摘 | Geraldine D Patrick P J M Conor D | 2007 | Analytica Chimica Acta2007，586，： | 1 |
| 16 | A Case-Based Explanation System for Black-Box Systems显示文摘 | Conor Nugent Pádraig Cunningham | 2005 | Artificial Intelligence Review2005，，2： | 1 |
| 17 | The rotective effect of profound hypothermia on the canine central nervous system in surgery of the ascending aorta and the aortic arch显示文摘 | CONOR J V WILDING T FARMER P | 1986 | Ann Tho2 rac Surg1986，41，： | 1 |
| 18 | Delaney Fastrointestinal Tract Recovery Inpatient Undergoing Bowel Resection显示文摘 | Kirk L Warren E Conor P | 2008 | Arch Surg2008，143，11： | 1 |
| 19 | Phase transitions of hexadecane in poly(alkyl methacrylate) core-shell microcapsules 显示文摘 | Jeremy K B Lauren E T Conor P R | 2010 | J Phys Chem B2010，114，12： | 1 |
| 20 | Confirmatory analysis of malachite green,leucomalachite green,crystal violet and leucocrystal violet in salmon by liquid chromatography-tandem mass spectrometry显示文摘 | Geraldine Dowling Patrick P J Mulder Conor Duffy | 2007 | Analytica Chimica Acta2007，586，： | 1 |
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