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| 1 | Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells显示文摘AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. RESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P < 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P < 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P < 0.05) adhesion to GP202 clones with larger MUC1 VNTR domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa. | Natália R Costa Nuno Mendes Nuno T Marcos Celso A Reis Thomas Caffrey Michael A Hollingsworth Filipe Santos-Silva | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 2 | 利奈唑胺和万古霉素治疗甲氧西林耐药金黄色葡萄球菌感染的疗效比较显示文摘甲氧西林耐药金葡菌(MRSA)感染可选择的治疗药物有限,多年来万古霉素是治疗的金标准。对万古霉素敏感性下降菌株的出现,增加了对新型抗感染药物的需求,噁唑烷酮类药物利奈唑胺是治疗MRSA感染的新药。然而,评价该药临床疗效的研究较少。 | Caffrey AR Quilliam BJ Laplante KL 秦晓华(摘译) 王明贵(审校) | 2011 | 中国感染与化疗杂志2011，11，4： | 2 |
| 3 | 不同血管紧张素转换酶抑制剂与高血压患者整体和病因特异性死亡率的相关性显示文摘血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)已广泛用于治疗高血压,比较不同药物降低死亡率有效性的研究却鲜有报道。方法:选取中国台湾地区全民健康保险数据库中从2004年1月1日至2009年12月31日开始用卡托普利、赖诺普利、依那普利、福辛普利、雷米普利、咪达普利或培哚普利治疗的高血压患者。整体和病因特异性死亡率通过中国台湾地区全民死亡登记来证实。从最初用ACEI开始随访患者直至死亡、退出研究或研究终止(2010年12月31日)。 | Chang CH Lin JW Caffrey JL Wu LC Lai MS | 2015 | 中华高血压杂志2015，23，9： | 2 |
| 4 | The Role of the Charged Residues of the GP2 Helical Regions in Ebola Entry显示文摘The glycoprotein(GP) of Ebola is the sole structural protein that forms the spikes on the viral envelope. The GP contains two subunits,GP1 and GP2,linked by a disulfide bond,which are responsible for receptor binding and membrane fusion,respectively. In this study,the full length of GP gene of Ebola Zaire species,2028 base pairs in length,was synthesized using 38 overlapping oligonucleotides by multiple rounds of polymerase chain reaction(PCR) . The synthesized GP gene was shown to be efficiently expressed in mammalian cells. Furthermore,an efficient HIV-based pseudotyping system was developed using the synthetic GP gene,providing a safe approach to dissecting the entry mechanism of Ebola viruses. Using this pseudotyping system and mutational analysis,the role of the charged residues in the GP2 helical regions was examined. It was found that substitutions of the most charged residues in the regions did not adversely affect GP expression,processing,or viral incorporation,however,most of the mutations greatly impaired the ability of GP to mediate efficient viral infection. These results demonstrate that these charged residues of GP2 play an important role in GP-mediated Ebola entry into its host cells. We propose that these charged residues are involved in forming the intermediate conformation(s) of GP in membrane fusion and Ebola entry. | Haiqing Jiang Jizhen Wang Balaji Manicassamy Santhakumar Manicassamy Michael Caffrey Lijun Rong | 2009 | Virologica Sinica2009，24，2： | 2 |
| 5 | A lipid's eye view of membrane protein crystalliza-tion in mesophases显示文摘 | Caffrey M | 2000 | Curr Opin Struct Biol2000，10，： | 1 |
| 6 | The roles of Muscarinic re- ceptor subtypes in modulation of nasal ciliary action 显示文摘 | Yang B Mc Caffrey T V | 1996 | Rhinology1996，34，3： | 1 |
| 7 | Thomsen- Friedenreich antigen expression in gastric carcinomas is associated with MUC1 mucin VNTR polymorphism 显示文摘 | Santos-Silva F Fonseca A Caffrey T | 2005 | Glycobiology2005，5，5： | 1 |
| 8 | Identification of DEBS 1, DEBS 2 and DEBS 3, the muhienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea 显示文摘 | Caffrey P Bevitt DJ Staunton J Leadlay PF 1992 | 1992 | FEBS Lett1992，304，： | 1 |
| 9 | Proteases in parasitic diseases显示文摘 | McKerrow J H Caffrey C Kelly B | 2006 | Annu Rev Pathol2006，1，： | 1 |
| 10 | Controlling release from the lipidic cubic phase by selective alkylation显示文摘 | Clogston J Craciun G Hart D J Caffrey M | 2005 | J Contr Rel2005，102，： | 1 |
| 11 | Membrane protein crystallization显示文摘 | Caffrey M | 2003 | J Struct Biol2003，142，1： | 1 |
| 12 | Superhydro- phobic surfaces by replication of micro/nano-structures fabrica- ted by uhrafast-laser-microtexturing显示文摘 | NAYAK B K CAFFREY P O SPECK C R | 2013 | Applied Surface Sci- ence2013，266，： | 1 |
| 13 | Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41 显示文摘 | Caffrey M Cai M Kaufman J | 1998 | EMBOJ1998，17，16： | 1 |
| 14 | Duct epithelial cells cultured from human pancreas processed for transplantation retain differentiated ductal characteristics显示文摘 | Caffrey T Hollingsworth M | 1997 | Pancreas1997，15，3： | 1 |
| 15 | Filamentous algal control using barley straw显示文摘 | CAFFREY J M MONAHAN C | 1999 | Hydrobiologia1999，415，： | 1 |
| 16 | Novel splice variants of sFhl are upregulated in preeclampsia 显示文摘 | Heydarian M Mc Caffrey T Florea L | 2009 | Placenta2009，30，3： | 1 |
| 17 | NICE clinical guideline:antibiotics for the prevention and treatment of early-onset neonatal infection显示文摘 | Caffrey OE Prentice P | 2014 | Arch Dis Child Educ Pract Ed2014，99，3： | 1 |
| 18 | P-selectin expression in a metastatic pancreatic tumor cell line (SUIT-2)显示文摘 | Iwamura T Caffrey TC Kitamura N | 1997 | Cancer Res1997，57，6： | 1 |
| 19 | Granite magma formation,transport and emplacement in the Earth's crust显示文摘 | Petford N Cruden A R Mc Caffrey K J W | 2000 | Nature2000，408，7： | 1 |
| 20 | Solution structure of the N- terminal zinc binding domain of HIV-1 integrase显示文摘 | Cai M Zheng R Caffrey M | 1997 | Nat Struct Biol1997，4，7： | 1 |
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