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| 1 | 抗血管生成因子Angiostatin与Endostatin作用下肿瘤血管生成的二维数值模拟显示文摘目的数值模拟抗血管生成因子Angiostatin和Endostatin对肿瘤血管生成的影响。方法建立肿瘤内外血管生成的二维离散数学模型。模型耦合两种抗血管生成因子Angiostatin和Endostatin的抑制效应,数值模拟在促血管生成因子诱导下肿瘤微血管网生成,讨论血管生成抑制因子的影响。结果抗血管生成因子Angiostatin对肿瘤内外血管网络生成的速度和成熟度有抑制作用。抗血管生成因子Angiostatin和Endostatin耦合作用时,在肿瘤血管生成的早期有明显的抑制效应;在肿瘤血管生成的中后期,它们可以降低肿瘤血管化程度。结论本文模型能够较好的模拟抗血管生成因子Angiostatin和Endostatin对内皮细胞迁移和增殖的抑制作用。 | 赵改平 高昊 吴洁 许世雄 Collins MW LONG Quan Carola Koenig Padhani AR | 2006 | 医用生物力学2006，21，4： | 10 |
| 2 | 实体肿瘤血管任意方向生成的二维数值模拟显示文摘目的二维数值生成实体肿瘤任意方向生长的血管网,为研究实体肿瘤内血液动力学、药物输运以及抗血管生成提供更趋真实的微血管网络结构。方法将新生血管芽尖的内皮细胞迁移方向由先前模型的上、下、左、右四个方向扩展为任意方向,建立相应的二维离散模型,数值模拟实体肿瘤微脉管系统的生成过程,比较模拟结果与相关实验数据的符合程度。结果对盲肠肿瘤微血管网进行数值模拟,与改进前的模型和其他模型比较,本模型生成的肿瘤微血管网结构特征,如血管的走向、扭曲、分叉与融合等,更接近生理实际,与实验观测图像的相似度更高。结论该模型可模拟实体肿瘤的微血管网生成,为肿瘤内血液微循环、药物传递以及抗血管生成的理论研究提供较为接近实际的微血管网络结构。 | 吴洁 许世雄 龙泉 Collins MW Carola Koenig 赵改平 蒋雨平 Padhani AR | 2007 | 医用生物力学2007，22，1： | 2 |
| 3 | Magnetic resonance image processing and structured grid generation of a human abdominal bifurcation 显示文摘 | LONG Q XU XY COLLINS MW | 2003 | Comput Methods Programs Biomed2003，37，11： | 1 |
| 4 | Reconstruction of blood flow patterns in human arteries 显示文摘 | XU XY LONG Q COLLINS MW | 1999 | J Eng Med1999，21，4： | 1 |
| 5 | Reconstruction of blood flow patterns in human arteries显示文摘 | Xu XY Long Q Collins MW | 1999 | J Eng Med1999，21，4： | 1 |
| 6 | Magnetic resonance image processing and structured grid generation of a human abdominal bifurcation显示文摘 | Long Q Xu XY Collins MW | 1998 | Computer Methods and Programs in Biomedicine1998，22，6： | 1 |
| 7 | Reconstruction of blood flow patterns in human arteries显示文摘 | Xu XY Long MW Collins M | 1999 | Journal of Engineering in Medicine1999，21，3： | 1 |
| 8 | KVLQT1 mutations in threefamilies with familial or sporadic long QT syndrome显示文摘 | Russell MW Dick M Collins FS | 1996 | Hum Mol Genet1996，5，： | 1 |
| 9 | Intravenous buprenorphine self-administration by detoxified heroin abusers显示文摘 | Comer SD Collins ED Fischman MW | 2002 | J Pharmacol Exp Ther2002，301，： | 1 |
| 10 | A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants 显示文摘 | Scott L J Mohlke KL Bonnycastle LL Wilier CJ Li Y Duren WL Erdos MR Stringham HM Chines PS Jackson AU Prokunina-Olsson L Dingl CJ Swift AJ Narisu N Hu T Pruim R Xiao R Li XY Conneely KN Riebow NL Sprau AG Tong M White PP Hetrick KN Barnhart MW Bark CW Goldstein JL Watkins J Xiang F Saramies J Buchanan TA Watanabe RM Valle TT Kinnunen L Abecasis GR Pugh EW Doheny KF Bergman RN Tuomilehto J Collins FS Boehnke M 2007 | 2007 | Science2007，3161，5829： | 1 |
| 11 | The Fas counterattack cancer as asite of immune privilege显示文摘 | Benner MW Collins JK | 1999 | Immunol Today1999，20，1： | 1 |
| 12 | Effectiveness of mouthguards in reducing neurocognitive deficits following sports-related cerebral concussion显示文摘 | Mihalik JP McCaffrey MA Rivera EM Pardini JE Guskiewicz KM Collins MW | | 0，，： | 1 |
| 13 | Improving identification and diagnosis of mild TBI with evidence:psychometric support for the acute concussion evaluation (ACE)显示文摘 | Gioia GA Collins MW Isquith PK | | 0，，： | 1 |
| 14 | Epidemiologic issues of sexually transmitted diseases in sexual assault victims显示文摘 | Reynolds MW Peipert JF Collins B | 2000 | Obstet Gynecol Surv2000，55，1： | 1 |
| 15 | Measurement of symptoms following sports-related concussion:reliability and normative data for the post-concussion scale显示文摘 | Lovell MR Iverson GL Collins MW Podell K Johnston KM Pardini D | | 0，，： | 1 |
| 16 | Which onfield signs/symptoms predict protracted recovery from sport-related concussion among high school football players显示文摘 | Lau BC Kontos AP Collins MW Mucha A Lovell MR | | 0，，： | 1 |
| 17 | Pneumocystis carinii pneumonia associated with profound lymphopenia and ab- normal T-lymphocyte subset ratios during treatment for earlystage breast carcinoma显示文摘 | Brunvand MW Collins C Livingston RB | 1991 | Cancer1991，67，： | 1 |
| 18 | Neurocognitive and symptom predictors of recovery in high school athletes显示文摘 | Lau B Lovell MR Collins MW Pardini J | | 0，，： | 1 |
| 19 | Open versus closed epididymal sperm retrieval in men with secondarily obstructed vasal systems--a preliminary report 显示文摘 | Collins GN Critchlow JD Lau MW | 1996 | Br J Urol1996，78，3： | 1 |
| 20 | Concussion in sports:postconcussive activity levels,symptoms,and neurocognitive performance显示文摘 | Majerske CW Mihalik JP Ren D Collins MW Reddy CC Lovell MR | | 0，，： | 1 |
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