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| 1 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 2 | 导致儿童期肥胖的生命早期危险因素:队列研究显示文摘目的确定早年(3岁以内)导致英国儿童肥胖的危险因素。设计前瞻性队列研究。方法Avon英国父母及儿童纵向调查研究。参与者参与队列研究的8234名年龄为7岁的儿童以及亚组的909名重点儿童,后者需额外提供与早期发育有关并涉及可能导致肥胖的各种资料。诊断标准7岁儿童体重指数≥95百分位确定为肥胖,参考1990年英国人口调查的诊断标准。结果经过最终验证,在假设的25项危险因素中有8项与肥胖有关:父母肥胖(父母双方校正后的相对危险度10.44,95%可信区间5.11~21.32);最早期(43个月内)的体重指数或体重反弹升高(校正后的相对危险度15.00,95%可信区间5.32~42.30);3岁时每周看电视的时间超过8小时(校正后的相对危险度1.55,95%可信区间1.13~2.12);追赶性生长(校正后的相对危险度2.60,95%可信区间1.09~6.16);8个月(校正后的相对危险度3.13,95%可信区间1.43~6.85)和18个月(校正后的相对危险度2.65,95%可信区间1.25~5.59)时体重的标准差值;1岁时体重增加值(校正后的相对危险度1.06,95%可信区间1.02~1.10,体重每增加100g);出生体重,每100g(校正后的相对危险度1.05,95%可信区间1.03~1.07);3岁时睡眠不足(<10.5小时,校正后的相对危险度1.45,95%可信区间1.10~1.89)。结论儿童期肥胖可能与8项危险因素有关。 | John J Reilly Julie Amstrong Ahmad R Dorosty Pauline M Emmett A Ness I Rogers Colin Steer Andrea Sherriff Children Study Team 冯凯 | 2005 | 英国医学杂志中文版2005，8，5： | 8 |
| 3 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 4 | 选择性环氧化酶2抑制剂和传统非甾体抗炎药增加粥样血栓形成的风险吗?随机试验的荟萃分析显示文摘目的:评价选择性环氧化酶2(COX-2)抑制剂和传统的非甾体类抗炎药(NSMDs)在发生血管事件上的风险性。设计:对已发表和未发表随机试验的表格式资料进行荟萃分析,对传统 NSAIDs 的作用进行间接评估。资料来源:资料分别来源于 Medline 和 Embase(1966年1月至2005年4月);食品与药品管理局记录;以及诺华、辉瑞、默克公司的资料。回顾方法:符合以下条件的随机试验入组本研究:一种选择性 COX-2抑制剂与安慰剂比较或一种选择性 COX-2抑制剂与一种传统的 NSAID之间对比;用药持续时间至少4周;包含严重血管事件方面的信息,如心肌梗死、卒中或由于血管事件死亡。各个独立研究者和药厂为本研究提供了有关随机化的病人数目、血管事件的数目以及每个随机化小组中随访的人时(Person time)等信息。结果:在与安慰剂对比的试验中,选择性COX-2抑制剂使严重血管事件发生率增加42%(1.2%/年比0.9%/年;率比1.42,95%可信区间1.13~1.78;P=0.005);不同的选择性 COX-2抑制剂之间没有显著性差异。这主要归因于心肌梗死的风险增加(0.6%/年比0.3%/年;1.86,1.33~2.59;P=0.0003),在其他血管性事件上没有明显的区别。在为时至少1年的试验中(平均2.7年),血管事件的率比是1.45(1.12~1.89;P=0.005)。总的来说,严重血管事件的发生率在选择性 COX-2抑制剂和任何传统 NSAID 之间没有差异(1.0%/年比0.9%/年;1.16,0.97~1.38;P=0.1)。然而,在选择性 COX-2抑制剂与萘普生对比的试验(1.57,1.21~2.03)和选择性COX-2抑制剂与非萘普生类 NSAIDs 相比较的试验之间(0.88,O.69~1.12),我们发现了统计学差异。与安慰剂比较血管事件的总体比率如下:萘普生0.92(0.67~1.26),布洛芬1.51(0.96~2.37),双氯芬酸1.63(1.12~2.37)。结论:选择性 COX-2抑制剂可以中等度增加血管事件的风险性,大剂量布洛芬和双氯芬酸同样具有此作用,但大剂量萘普生不明显增加血管事件的风险性。 | Patricia M Kearney Colin Baigent Jon Godwin Heather Halls Jonathan R Emberson Carlo Patrono 徐东(译) 张卓莉(校) | 2006 | 英国医学杂志中文版2006，9，5： | 4 |
| 5 | Cabozantinib in Progressive Medullary Thyroid Cancer显示文摘 | Rossella Elisei Martin J. Schlumberger Stefan P. Müller Patrick Sch?ffski Marcia S. Brose Manisha H. Shah Lisa Licitra Barbara Jarzab Viktor Medvedev Michael C. Kreissl Bruno Niederle Ezra E.W. Cohen Lori J. Wirth Haythem Ali Colin Hessel Yifah Yaron Doug | 2013 | Journal of Clinical Oncology2013，，29： | 3 |
| 6 | US report raises fears over nitrate levels in water显示文摘 | Colin M | 1995 | Nature1995，377，： | 2 |
| 7 | Evolution of endovascular mechanical thrombectomy for acute ischemic stroke显示文摘Acute ischemic stroke(AIS) is a common medical problem associated with significant morbidity and mortality worldwide. A small proportion of AIS patients meet eligibility criteria for intravenous thrombolysis(IVT) with recombinant tissue plasminogen activator, and its efficacy for large vessel occlusion is poor. Therefore, an increasing number of patients with AIS are being treated with endovascular mechanical thrombectomy when IVT is ineffective or contraindicated. Rapid advancement in catheter-based and endovascular device technology has led to significant improvements in rates of cerebral reperfusion with these devices. Stentrievers and modern aspiration catheters have now surpassed earlier generation devices in the degree and rapidity of revascularization. This progress has been achieved with no concurrent increase in risk of major complications or mortality, both when used alone or in combination with IVT. The initial randomized controlled trials comparing endovascular therapy to IVT for AIS failed to show superior outcomes with endovascular treatment, butkey limitations of each trial may limit the significance of these results to current practice. While endovascular devices and operator experience continue to evolve, we are optimistic that this will be accompanied by improvements in patient outcomes. This review highlights the major endovascular devices used in current practice and the trials which have investigated their efficacy. | Colin J Przybylowski Dale Ding Robert M Starke Christopher R Durst R Webster Crowley Kenneth C Liu | 2014 | World Journal of Clinical Cases2014，2，11： | 2 |
| 8 | Preinoculation enrichment procedure enhances the performance of bacteriocinogenic Lactocoocus lactic meat starter culture 显示文摘 | Amalia G M Scannell Gerhard Schwarz Colin Hill | 2001 | International Journal of Food Microbiology2001，64，： | 1 |
| 9 | The individual, Community and Sodiety, Right and Responsibilities from An Anthropological Perspective显示文摘 | Colin M ·Turnbull | 1984 | Washington and Lee Law Review1984，41，： | 1 |
| 10 | Altemeier's procedure for rectal prolapse: analysis of long-term outcome in 60 patients 显示文摘 | Ris F Colin JF Chilcott M | 2012 | Colorectal Dis2012，14，： | 1 |
| 11 | Effects of water availability and pest pressures on tea (Camellia sinensis ) growth and functional quality 显示文摘 | Selena Ahmed Colin M Orians Timothy S Griffin | 2013 | AoB plants advance access2013，，： | 1 |
| 12 | Longitudinal study of children with perinatal braindamage in whom early neurohabilitation was applied: Pre- liminary report显示文摘 | Harmony T Barrera Resendiz J Juarez Colin M E | 2015 | Neurosci Lett2015，611，： | 1 |
| 13 | Evidence for the adsorption of molecules at special sites located at copper/zinc oxide interfaces (Part 3): Fourier-transform infrared study of methyl formate adsorption on reduced and oxidised Cu/ ZnO/SiO2 catalysts显示文摘 | Graeme J M Colin H R | 1992 | J Chem Soc Faraday Trans1992，88，23： | 1 |
| 14 | Murine Denys - Drash syndrome: evi dence of podocyte de - differentiation and systemic mediation of glomerul - oselerosis 显示文摘 | Charles E P Stewart F Colin G M | 2003 | Human Molecular Genetics2003，12，18： | 1 |
| 15 | Not sodifferent after all:a crossdiscipline view of trust显示文摘 | Dennise M Rousseau Sim B Sitkin Colin Camerer | 1998 | Academy of Management Review1998，，3： | 1 |
| 16 | The Effect of a Worksite Based Walking Program on Cardiovascular Risk in Previously Sedentary Civil Servants显示文摘 | Marie H M Elaine M M Colin A G B | 2006 | BM C Public Health2006，6，： | 1 |
| 17 | Degradation of lambda-carrageenan by Pseudoalteromonas carrageenovora lambda-carrageenase: a new family of glycoside hydrolases unrelated to kappa-and iota-carrageenases显示文摘 | Guibet M Colin S Barbeyron T | 2007 | Biochem J2007，404，1： | 1 |
| 18 | Enhanced binding of Aspergillus fumigatus spores to A549 epithelial ceils and extraeellular matrix proteins by a component from the spore surface and inhibition by rat lung lavage fluid 显示文摘 | ZHAN Y STEPHANIE M H COLIN G M | 2000 | Thorax2000，55，10： | 1 |
| 19 | The Size of the Informal Venture Capital Market in the United Kingdom显示文摘 | Mason Colin M Harrison Richard | 2001 | Small Business Economics2001，15，： | 1 |
| 20 | The interaction between bacteria and bile显示文摘 | Máire Begley Cormac G.M. Gahan Colin Hill | 2004 | FEMS Microbiology Reviews2004，，4： | 1 |
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