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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Contribution of TLR signaling to the pathogenesis of colitisassociated cancer in inflammatory bowel disease显示文摘In the intestine a balance between proinflammatory and repair signals of the immune system is essential for the maintenance of intestinal homeostasis. The innate immunity ensures a primary host response to microbial invasion, which induces an inflammatory process to localize the infection and prevent systemic dissemination of pathogens. The key elements of this process are the germline encoded pattern recognition receptors inclu-ding Toll-like receptors(TLRs). If pathogens cannot be eliminated, they may elicit chronic inflammation, which may be partly mediated via TLRs. Additionally, chronic inflammation has long been suggested to trigger tissue tumorous transformation. Inflammation, the seventh hallmark of cancer, may affect all phases of tumor development, and evade the immune system. Inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability. Furthermore, chronic inflammation can provoke genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Colorectal cancers in inflammatory bowel disease patients are considered typical examples of inflammation-related cancers. Although data regarding the role of TLRs in the pathomechanism of cancer-as-sociated colitis are rather conflicting, functionally these molecules can be classified as 'largely antitumorigenic' and 'largely pro-tumorigenic' with the caveat that the underlying signaling pathways are mainly context(i.e., organ-, tissue-, cell-) and ligand-dependent. | Ferenc Sipos István Fri Miklós Constantinovits Zsolt Tulassay Gyrgyi Mzes | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | 强制对流条件下不同传热流体对含相变材料柱形容器放热性能的影响显示文摘本文采用数值模拟方法研究了强制对流条件下不同传热流体对含相变材料柱形容器的放热性能的影响。以空气、氢、水和含氧化铝颗粒的纳米流体作为传热流体,同时考虑了含相变材料(PCM)区域的结构变化,采用有限元法进行求解。研究了不同传热流体类型、雷诺数(100~300)和含PCM区域结构变化(h_(x)在0.01d_(1)~0.65d_(1),h_(y)在0.1h_(1)~0.4h_(1))下不同相的换热动力学特征。研究发现,换热流体类型对放热时间影响较大,以空气为换热流体时相变完成时间比以空气为换热流体时的长10倍以上,而以纳米流体为换热流体时的时间最短。当含PCM区域减小时,放热时间缩短。含PCM区域的结构导致涡流的形成,这使在内筒的半径和高度最大处的性能下降。当内筒半径从h_(x)=0.35d_(1)增加到h_(x)=0.45d_(1)时,放热时间延长约12%。在不同雷诺数下,PCM的温度和液体组分的动态特性均受雷诺数的影响,与最小雷诺数相比,最大雷诺数下的PCM的放电时间缩短了48%左右。 | SELİMEFENDİGİL Fatih ŞİRİN Ceylin ÖZTOP Hakan F | 2021 | Journal of Central South University2021，28，11： | 2 |
| 4 | Diffusion tensor MRI of the human kidney显示文摘 | Ries M Jones RA Basseau F | 2001 | J Magn Reson Imaging2001，14，1： | 1 |
| 5 | Investigation of the expression of melanoma antigen-encoding genes( MAGE-A1 to -AS ) in oral squamous cell carcinomas to determine potential targets for gene-based cancer immunotherapy 显示文摘 | Ries J Schultze-Mosgau S Neukam F Diebel E Wiltfang J | 2005 | Int J Oncol2005，26，3： | 1 |
| 6 | Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functio- ning显示文摘 | Vetreno RI Crews F | 2015 | Front Neurosci2015，9，： | 1 |
| 7 | Diffusion tensor M RI of the human kidney显示文摘 | Ries M Jones RA Basseau F | 2001 | Magn Reson Imaging2001，14，： | 1 |
| 8 | Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes显示文摘 | Ries C Loher F Zang C B | 1999 | Clin Cancer Res1999，5，5： | 1 |
| 9 | Biodistribu tion and gene expression of lipid/plasmid complexes after systemic administration显示文摘 | MAHATO RI ANWER KS TAGLIAFERRI F | 1998 | Hum Gene Ther1998，9，14： | 1 |
| 10 | The role of CC10 in Pulmonary carcinogenesis: From a marker to tumor suppression显示文摘 | Linnoila RI Szabo E Demayo F | 2000 | Ann N Y Acad sci2000，923，： | 1 |
| 11 | The congenital bilateral perisylvian syndrome:study of 31 patients显示文摘 | Andermann F Guerrini R | 1993 | Lancet1993，341，3： | 1 |
| 12 | Prolonged respiratory in?suffieieney due to aeute motor neuropathy: a new syndome?显示文摘 | Roelofs RI Cerra F Beilk N | 1993 | Neurology(Cleveland)1993，，： | 1 |
| 13 | MicroRNAs: new players in multiple myeloma显示文摘 | Pichiorri F De Luca L Aqeilan RI | 2011 | Front Genet2011，2，： | 1 |
| 14 | Ten-year results following treatment of intrabony defects with an enamel matrix protein derivative combined with either a natural bone mineral or aβ-tricalcium phosphate显示文摘 | Dri F Arweiler NB SzántóE | 2013 | J Periodontol2013，84，6： | 1 |
| 15 | Targeted deletion of WWOX reveals a tumor suppressor function 显示文摘 | Aqeilan RI Trapasso F Hussain S | 2007 | PNAS2007，104，： | 1 |
| 16 | The congenital bilateral perisylvian syndrome:study of 31 patients显示文摘 | Andermann F Guerrini R | 1993 | Lancet1993，341，3： | 1 |
| 17 | Human CD4^+CD25^+ regulatory cells have marked and sustained effects on CD8^+T cell activation显示文摘 | Camara NO Sebille F Lechler RI | 2003 | Eur J Immunol2003，33，： | 1 |
| 18 | Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer显示文摘 | Veroni F Nieri M Aqeilan RI | 2006 | Genes Chromosomes Cancer2006，45，5： | 1 |
| 19 | Human CD4 + CD25 + regulatory cells have marked and sustained effects on CD8 + T cell activation 显示文摘 | Camara NO Sebille F Lechler RI | 2003 | Eur J Immunol2003，33，12： | 1 |
| 20 | Diffusion tensor MRIof the human kidney 显示文摘 | Ries M Jones RA Basseau F | 2001 | J Magn Reson Imaging2001，14，： | 1 |
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