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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 3 | Clearance of vancomycin during high-volume heamofiltration: impact of pre-dilution 显示文摘 | Uchino S Cole L Morimatsu H | 2002 | Intensive Care Med2002，，28： | 2 |
| 4 | Novel Brφ nsted acidic ionic liquids and their use as dualsolventcatalysts显示文摘 | Amanda C Cole Jessica L Ioanna Ntai | 2002 | J Am Chem Soc2002，124，： | 1 |
| 5 | Terminal restriction fragment length polymorphism an analysis program,a web-based research tool for microbial community analysis显示文摘 | Marsh T L Saxman P Cole J | 2000 | Appl Environ Microbiol2000，66，8： | 1 |
| 6 | Human chorionic gonadotropin tests显示文摘 | Cole L A | 2009 | Expert reviews Mol Diagn2009，9，7： | 1 |
| 7 | Use of biosolids in the forest: Technology, economics and regulations显示文摘 | HENRY C L COLE D W | 1997 | Biomass and Bioenergy1997，13，4： | 1 |
| 8 | Novel bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 9 | The Forgotten Stakeholder? Ethics and Social Respon- sibility in Relation to Competitors 显示文摘 | Spence L J Coles A Harris L | 2001 | Business and Society Review2001，106，4： | 1 |
| 10 | Bacterial production in fresh and saltwater ecosystems : a cross - system overview显示文摘 | Cole J J Findlay S Pace M L | 1988 | Mar Ecol Prog Set1988，43，： | 1 |
| 11 | Preliminary experience with high-volume hemofiltration in human septic shock显示文摘 | Bellomo R Baldwin I Cole L | 1998 | Kidney Inter1998，53，166： | 1 |
| 12 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 13 | Remediation of pesticide contaminated soil by planting and compost addition 显示文摘 | COLE M A ZHANG L LIU X | 1995 | Compost Sci Utiliza1995，3，4： | 1 |
| 14 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 15 | Enteric coated HPMC capsules designed to achieve intestinal targeting显示文摘 | Ewart T Cole Robert A Scott Alyson L Connor Ian R Wilding Hans-U Petereit Carsten Schminke Thomas Beckert Dominique Cadé | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 16 | Peroxi- some proliferator-activated receptor gamma (PPAR gam- ma) and its ligands: a review 显示文摘 | HOUSEKNECHT K L COLE B M STEELE P J | 2002 | Domest Anim Endocri- nol2002，22，1： | 1 |
| 17 | Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more eficiently than doesvitamin D2显示文摘 | TRANG H COLE D E RUBIN L A | | American Journal of Clinical Nutrition0，998，68： | 1 |
| 18 | Dutch techniques for the establishment of natural plant communities in urban areas显示文摘 | COLE l KEEN C | 1976 | Landscape Design1976，116，： | 1 |
| 19 | Spinal stenosisprevalence and association with symptoms:the Framingham study显示文摘 | KALICHMAN L COLE R KIM DH | 2009 | Spine2009，9，7： | 1 |
| 20 | Anthracycline derivatives from a marine-derived New Zealand streptomycete 显示文摘 | Phipps R K Blunt J W Cole A L J | 2004 | ARKIVOC2004，，10： | 1 |
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