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| 1 | Adrenomedullin and endocrine control of immune cells during pregnancy显示文摘怀孕的免疫学复杂、不完全地听说。在蜕膜并且在胎盘的异常有免疫力的活动被相信在怀孕的疾病起一个作用,例如不孕,流产,胎儿的生长限制和 preeclampsia。这里,我们简短由肽荷尔蒙 adrenomedullin 考察子宫的自然漂亮房间人口和他们的功能的内分泌的控制。在基因动物模型的研究在母亲胎儿的接口揭示了 adrenomedullin 剂量的批评重要性,与从两个的细胞贡献位于适当子宫的感受性,培植并且螺线动脉的脉管的改变下面的必要方面的母亲、胎儿的分隔空间。这些基本卓见进串音在之间内分泌并且在母亲胎儿的接口以内的免疫系统可以最终在临床上复杂的怀孕翻译到功能的更好的理解和 dysregulated adrenomedullin 层次的后果。 | Brooke C Matson Kathleen M Caron | 2014 | Cellular & Molecular Immunology2014，11，5： | 4 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 4 | p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘 | Dean J L Brook M Clark A R | 1999 | J Biol Chen1999，274，： | 1 |
| 5 | Synchronous liver resection and cryotherapy for colorectal metastases : survival analysis 显示文摘 | Brooks A J Wang F Alfredson M d al | 2005 | Surgeon2005，3，4： | 1 |
| 6 | Mutations in ABC1 in Tan- gier disease and familial high-density lipoprotein deficiency显示文摘 | Brooks WA Marcil M Clee S M | 1999 | Nat Genet1999，22，4： | 1 |
| 7 | Virus infection expands a biased subset of T ceils that bind tetrameric class I peptide complexes 显示文摘 | COLES R M JONES C M BROOKS A G | 2003 | Eur J Immunol2003，33，6： | 1 |
| 8 | Optimalclinical timelines-a consensus from the academic department ofmilitary surgery and trauma显示文摘 | Tai NR Brooks A Midwinter M Clasper JC Parker PJ | 2009 | J R Army Med Corps2009，155，4： | 1 |
| 9 | Guidelines for the managment of acute pancreatieis显示文摘 | Toorli J Brooke - Smith M Bassi C | 2002 | Gastroen Cerol Hepatol2002，7，17： | 1 |
| 10 | Chemical and biological remediation of the benthos near Atlantic salmon farms 显示文摘 | Brooks K M Stiems A R Mahnken C V W | 2003 | Aquaculture2003，255，： | 1 |
| 11 | The world according to hedgehog显示文摘 | Hammerschmidt M Brook A McMahon AP | | 0，，： | 1 |
| 12 | A deconvolution ap-proach for the mapping of acoustic sources ( DAMAS) de-termined from phased microphone arrays 显示文摘 | BROOKS T F HUMPHREYS W M | 2006 | Journal ofSound and Vibration2006，294，45： | 1 |
| 13 | Characterization of porcine plasma ficolins that bind Actinobacillus pleuropneumoniae serotype 5B显示文摘 | BROOKS A S DELAY J P HAYES M A | 2003 | Immunobiology2003，207，： | 1 |
| 14 | Recognizing speech under a processing load:Dissociatting energetic from informational factors显示文摘 | Mattys S L Brooks J Cooke M | | 0，，03： | 1 |
| 15 | Identification and characterization of inland ship plumes over Vancouver, BC显示文摘 | Lu G Brook J R Rami Alfarra M | 2006 | Atmospheric Environment2006，40，15： | 1 |
| 16 | Lexicon-based methods for sentiment analysis 显示文摘 | TABOADA M BROOKE J TOFILOSKI M | 2011 | Computational Linguistics2011，37，2： | 1 |
| 17 | Optic atrophies in metabolic disorders显示文摘 | Huizing M Brooks BP Anikster Y | 2005 | Mol Genet Metab2005，86，12： | 1 |
| 18 | Biomass torrefaction studies with a molecular beam mass spectrometer显示文摘 | NIMLOS M N BROOKING E LOOKER M | 2003 | American Chemical Society Division of Petroleum Chemistry2003，48，2： | 1 |
| 19 | Light hydrocarbons in recent Texas continental shelf and slope sediments显示文摘 | Bernard B B Brook J M Sackett W M | 1978 | Journal of Geophysical Research1978，83，8： | 1 |
| 20 | The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling显示文摘 | Myers M G Grammer T C Brooks J | 1995 | J Biol Chem1995，270，11： | 1 |
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