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| 1 | Lipid metabolism reprogramming and its potential targets in cancer显示文摘Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.Increased lipid uptake,storage and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth.Lipids constitute the basic struc-ture of membranes and also function as signaling molecules and energy sources.Sterol regulatory element-binding proteins(SREBPs),a family of membrane-bound transcription factors in the endoplasmic reticulum,play a central role in the regulation of lipid metabolism.Recent studies have revealed that SREBPs are highly up-regulated in various cancers and promote tumor growth.SREBP cleavage-activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor,thus linking glucose metabolism and de novo lipid synthesis.Targeting altered lipid metabolic pathways has become a promising anti-cancer strategy.This review summarizes recent progress in our understanding of lipid metabolism regulation in malignancy,and highlights potential molecu-lar targets and their inhibitors for cancer treatment. | Chunming Cheng Feng Geng Xiang Cheng Deliang Guo | 2018 | Cancer Communications2018，38，1： | 34 |
| 2 | Application of pressure relief and permeability increased by slotting a coal seam with a rotary type cutter working across rock layers显示文摘Pressure relief to increase permeability significantly improves gas extraction efficiency from coal seams.In this paper we report results from simulations using FLAC 3D code to analyze changes in coal displacement and stress after special drill slots were formed.We investigated the mechanism of pressure relief and permeability increase in a high-gas and low-permeability coal seam through the modeling of gas flow.This allows the development of the technology.Slotting across rock layers in the coal seam with a rotary type cutter was then applied in the field.The results show that pressure relief and permeability increases from slotting the coal seam can increase the transport and the fracture of the coal.This expands the range of pressure relief from the drilling and increases the exposed area of the seam.The total quantity of gas extracted from slotted bore holes was three times that seen with ordinary drilling.The concentration of gas extracted from the slotted drills was from two to three times that seen using ordinary drills.The gas flow was stable at 80%.Improved permeability and more efficient gas extraction are the result of the slotting.The roadway development rate is increased by 30-50% after gas drainage.This technology diminishes the lag between longwall production and roadway development and effectively prevents coal and gas outburst,which offers the prospect of broad application. | Shen Chunming Lin Baiquan Meng Fanwei Zhang Qizhi Zhai Cheng | 2012 | International Journal of Mining Science and Technology2012，22，4： | 10 |
| 3 | Identity Based Encryption and Biometric Authentication Scheme for Secure Data Access in Cloud Computing显示文摘 | CHENG Hongbing RONG Chunming TAN Zhenghua ZENG Qingkai | 2012 | Chinese Journal of Electronics2012，21，2： | 10 |
| 4 | Secure Big Data Storage and Sharing Scheme for Cloud Tenants显示文摘The Cloud is increasingly being used to store and process big data for its tenants and classical security mechanisms using encryption are neither sufficiently efficient nor suited to the task of protecting big data in the Cloud.In this paper,we present an alternative approach which divides big data into sequenced parts and stores them among multiple Cloud storage service providers.Instead of protecting the big data itself,the proposed scheme protects the mapping of the various data elements to each provider using a trapdoor function.Analysis,comparison and simulation prove that the proposed scheme is efficient and secure for the big data of Cloud tenants. | CHENG Hongbing RONG Chunming HWANG Kai WANG Weihong LI Yanyan | 2015 | China Communications2015，12，6： | 10 |
| 5 | Identification and fine mapping of two blast resistance genes in rice cultivar 93-11显示文摘Rice blast, caused by Magnaporthe oryzae, is a major disease of rice almost worldwide. The Chinese indica cultivar 93-11 is resistant to numerous isolates of the blast fungus in China, and can be used as broad-spectrum resistance resource, particularly in japonica rice breeding programs. In this study, we identified and mapped two blast resistance genes, Pi60(t) and Pi61(t), in cv. 93-11 using F2 and F3 populations derived from a cross between the susceptible cv. Lijiangxintuanheigu(LTH) and resistant cv. 93-11 and inoculated with M. oryzae isolates from different geographic origins. Pi60(t) was delimited to a 274 kb region on the short arm of chromosome 11, flanked by InDel markers K1-4 and E12 and cosegregated with InDel markers B1 and Y10. Pi61(t) was mapped to a 200 kb region on the short arm(near the centromere) of chromosome 12, flanked by InDel markers M2 and S29 and cosegregating with InDel marker M9. In the 274 kb region of Pi60(t), 93-11 contains six NBS-LRR genes including the two Pia/ PiCO39 alleles(BGIOSGA034263 and BGIOSGA035032) which are quite close to the two Pia/ PiCO39 alleles(SasRGA4 and SasRGA5) in Sasanishiki and CO39, with only nine amino acids differing in the protein sequences of BGIOSGA035032 and SasRGA5. In the 200 kb region of Pi61(t), 93-11 contains four NBS-LRR genes, all of which show high identities in protein sequence with their corresponding NBS-LRR alleles in susceptible cv. Nipponbare. Comparison of the response spectra and physical positions between the target genes and other R genes in the same chromosome regions indicated that Pi60(t) could be Pia/PiCO39 or its allele, whereas Pi61(t) appears to be different from Pita, Pita-2, Pi19(t), Pi39(t) and Pi42(t) in the same R gene cluster. DNA markers tightly linked to Pi60(t) and Pi61(t) will enable marker-assisted breeding and map-based cloning. | Cailin Lei Kun Hao Yilong Yang Jian Ma Shuai Wang Jiulin Wang Zhijun Cheng Shasha Zhao Xin Zhang Xiuping Guo Chunming Wang Jianmin Wan | 2013 | The Crop Journal2013，1，1： | 8 |
| 6 | 脂质代谢重编程及其在癌症中潜在靶点的研究显示文摘脂质代谢的重编程是恶性肿瘤的一个新特征。在多种癌症中,脂肪摄取、储存和脂肪生成均被上调,这也促进了肿瘤的快速生长。脂质是构成膜的基本结构,并且具有信号分子和能量来源的功能。固醇调节元件结合蛋白(Sterol regulatory element-binding proteins,SREBPs)是内质网中一类膜结合转录因子,在调节脂质代谢中起着核心作用。最近的研究表明,SREBPs在各种癌症中高度上调并促进肿瘤生长。SREBP切割激活蛋白(SREBP cleavage-activating protein,SCAP)是SREBPs转运和激活的关键转运蛋白,也是一种关键的葡萄糖传感器,因此它将葡萄糖代谢与脂类从头合成联系在一起。靶向变异的脂质代谢途径已成为一种很有前景的抗癌策略。本综述总结了近年来我们所知的对恶性肿瘤中脂质代谢调节的最新研究进展,并着重介绍了癌症治疗中潜在的分子靶点及其抑制剂。 | Chunming Cheng Feng Geng Xiang Cheng Deliang Guo | 2018 | 癌症2018，37，11： | 6 |
| 7 | Analysis and synthesis of switched nonlinear systems using the T-S fuzzy model 显示文摘 | Chiou Juingshian WANG Chijo CHENG Chunming | 2010 | Applied Mathematical Modeling2010，34，6： | 1 |
| 8 | Rock-salt and helix structures of silver iodides under ambient conditions显示文摘Many different phase structures have been discovered for silver iodides. The β and γ phases were found to be the most common ones at ambient conditions, while the rock-salt phase was found to be stable under pressures between 400 MPa and 11.3 GPa. Recently, the α phase was demonstrated to be stable under ambient conditions when the particle sizes were reduced to below 10 nm. However, no other phase has been reported to be stable for silver iodides under ambient conditions. Rock-salt and helix structures have been found to be stable under ambient conditions in this study. The structures have been characterized by elemental mapping, Raman scattering, and high-resolution transmission electron microscopy. The stabilities of these structures were also confirmed by molecular dynamics and density functional theory. | Hongyang Huang Jinying Zhang Yifan Zhang Chengcheng Fu Jialiang Huang Yonghong Cheng Chunming Niu Xinluo Zhao Hisanori Shinohara | 2019 | National Science Review2019，6，4： | 1 |
| 9 | Tanshinone Ⅱ A attenuates peritoneal fibrosis through inhibition of fi- brogenic growth factors expression in peritoneum in a peritoneal dialysis rat model显示文摘 | Chunming J Miao Z Cheng S | 2011 | Ren Fail2011，33，3： | 1 |
| 10 | Identification, pathogenicity, and fungicide sensitivity of Eutiarosporella dactylidis associated with leaf blight on maize in China显示文摘Maize(Zea mays L.) is an economically vital grain crop that is cultivated worldwide. In 2011, a maize foliar disease was detected in Lingtai and Lintao counties in Gansu Province, China. The characteristic signs and symptoms of this disease include irregular chlorotic lesions on the tips and edges of infected leaves and black punctate fruiting bodies in dead leaf tissues. Given favourable environmental conditions, this disease spread to areas surrounding Gansu. In this study, infected leaves were collected from Gansu and Ningxia Hui Autonomous Region between 2018and 2020 to identify the disease-causing pathogen. Based on morphological features, pathogenicity tests, and multilocus phylogenetic analysis involving internal transcribed spacer(ITS), 18S small subunit rDNA(SSU), 28S large subunit rDNA(LSU), translation elongation factor 1-alpha(TEF), and β-tubulin(TUB) sequences, Eutiarosporella dactylidis was identified as the causative pathogen of this newly discovered leaf blight. Furthermore, an in vitro bioassay was conducted on representative strains using six fungicides, and both fludioxonil and carbendazim were found to significantly inhibit the mycelial growth of E. dactylidis. The results of this study provide a reference for the detection and management of Eutiarosporella leaf blight. | Cheng Guo Xiaojie Zhang Baobao Wang Zhihuan Yang Jiping Li Shengjun Xu Chunming Wang Zhijie Guo Tianwang Zhou Liu Hong Xiaoming Wang Canxing Duan | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 11 | Artificial intelligence-aided discovery of prolyl hydroxylase 2 inhibitors to stabilize hypoxia inducible factor-1α and promote angiogenesis显示文摘From ZINC database with a total of 1.8 million small molecules, four compounds are identified as prolyl hydroxylase 2 inhibitors through a virtual screening workflow that sequentially incorporates machine learning, molecular docking, and molecular dynamics. Among them, compound 103,(E)-5-(5-((2-(1Htetrazol-5-yl)hydrazineylidene)methyl)furan-2-yl)isoindoline-1,3-dione, promotes the migration and capillary tube formation capacity of human umbilical vein endothelial cells through enhancing the stability of hypoxia inducible factor-1α and increasing the level of vascular endothelial growth factor. | Jianzhong Zhu Cheng Chen Jie Dong Shasha Cheng Guodong Li Chunming Wang Defang Ouyang Chung-Hang Leung Ligen Lin | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 12 | A Survey on Cloud Security显示文摘Cloud computing system packages infrastructures,applications and other resources as services,and delivers the services to market in an elastic and fast way.The significant advantages of cloud computing,e.g.,scalability,elasticity,and pay-per-use,bring it considerable commercial values.Nevertheless,owing to the new application scenario,e.g.,multi-tenant,cloud computing is encountering potential security risks.This paper reviews the state-of-art research in cloud security.According to the attack levels,it analyzes four kinds of attacks in the cloud,i.e.,network-based attacks,VM-based attacks,storage-based attacks,and application-based attacks.The countermeasures and corresponding techniques are then introduced.Furthermore,this paper also discusses an innovative and promising solution for cloud security by dynamically changing system configuration. | WU Chunming LIU Qianjun LI Yuwei CHENG Qiumei ZHOU Haifeng | 2017 | ZTE Communications2017，15，2： | 0 |
| 13 | Role of oxygen vacancy in rare-earth-free LiCa_(3)Mg(VO_(4))_(3) phosphor: Enhancing photoluminescence by heat-treatment in oxygen flow显示文摘As a kind of white light emitting diode(w-LED)with many advantages,rare-earth-free vanadate phosphor has attracted more and more attention.The oxygen vacancies and other surface defects in vanadate oxide have obvious effects on its structure and properties.In order to reveal the specific effects,we heat-treat the original LiCa_(3)Mg(VO_(4))_(3)(LCMV)in an oxygen flow with different time to decrease oxygen vacancies,and find that the lattice distortion of[VO_(4)]tetrahedron caused by oxygen vacancy is effectively reduced.Meanwhile,the crystallinity of the treated samples increases,the surface defects decreases,and the fluorescence intensity increases.The variation of photoluminescence quantum yield(PLQY)with oxygen treatment time is as follows:the enhancement effect firstly reaches the strongest(69.34%)within one hour,then begins to decline after two hours,and finally reaches the platform after three hours and remains basically unchanged.The reason for the enhancement of PLQY is the decrease of oxygen vacancy after one-hour treatment,and the reason for the decrease of PLQY after a further increased treatment time is that the absorption of oxygen and water in air caused by excessive surface defects introduced by oxygen treatment. | Yixuan Lv Yijun Zhang Le Shi Jian-Wen Shi Jun Li Zhihui Li Xin Ji Dandan Ma Yonghong Cheng Chunming Niu | 2021 | Journal of Materials Science & Technology2021，，20： | 0 |
| 14 | Variable selection procedures from multiple testing显示文摘Variable selection has played an important role in statistical learning and scienti?c discoveries during the past ten years, and multiple testing is a fundamental problem in statistical inference and also has wide applications in many scienti?c ?elds. Signi?cant advances have been achieved in both areas. This study attempts to ?nd a connection between the adaptive LASSO(least absolute shrinkage and selection operator) and multiple testing procedures in linear regression models. We also propose procedures based on multiple testing methods to select variables and control the selection error rate, i.e., the false discovery rate. Simulation studies demonstrate that the proposed methods show good performance relative to controlling the selection error rate under a wide range of settings. | Baoxue Zhang Guanghui Cheng Chunming Zhang Shurong Zheng | 2019 | Science China Mathematics2019，62，4： | 0 |
| 15 | Optimum Control Scheme of Output Voltage Based on Cascaded H-bridge DVR显示文摘This study presents an optimum control scheme to maximize the output voltage level number of the cascaded Hbridge dynamic voltage restorer(CHB–DVR).The relationship between the modulation index and the output voltage level number is analyzed in detail.The compensation reference voltage value is adjusted with the voltage drop depth to obtain high-quality output voltage with an acceptable total harmonic distortion.Thus,the modulation index remains within a certain range and thus meets the requirements of the maximum level number technique(MLNT).In addition,an improvement method based on the MLNT is proposed to achieve minimum active power absorption from a direct current link of the CHB–DVR.The traditional in-phase compensation and optimum control strategies are implemented to analyze the output voltage quality for verifying the feasibility of the proposed approach.Simulation and experimental results show the effectiveness of the proposed control scheme. | Fei Jiang Siju Cheng Chunming Tu Qi Guo Qing Li Cheng Chen | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 0 |
| 16 | Glutamine-released ammonia acts as an unprecedented signaling molecule activating lipid production显示文摘In healthy humans, ammonia circulates in the bloodstream at a concentration around 11–32 μmol/L. Whether ammonia plays any physiological role has been unknown until a recent report published in Nature Metabolism.1 Ammonia, long thought to be a toxic waste product of amino acid metabolism, needs to be excreted from the human body as urea. Intriguingly, in this paper, Cheng et al1 for the first time reported that ammonia is not a waste product;rather, it is an unprecedented signaling molecule tying glucose and glutamine to lipid production in human cells. This study revealed that ammonia released from glutamine triggers a cascade of cellular processes leading to the activation of lipogenesis machinery for lipid production (Fig. 1). This discovery has major implications for developing treatments for human diseases such as cancers and metabolic syndromes, as dysregulated metabolism is a hallmark of these diseases. | Chunming Cheng Scott Kelsey Deliang Guo | 2023 | Genes & Diseases2023，10，2： | 0 |
| 17 | Efficient middlebox scaling for virtualized intrusion prevention systems in software-defined networks显示文摘Dear editor,An intrusion prevention system(IPS)[1]is an important security function that detects and filters out the detected anomaly data traffic in networks.Currently,network function virtualization(NFV)[2]is able to virtualize IPSes as virtualized IPS(VIPS)[3]by encapsulating security functions in software-based middleboxes that can be elastically scaled to deal with traffic volume variations[4,5]. | Junchi XING Chunming WU Haifeng ZHOU Qiumei CHENG Danrui YU Mayra MACAS | 2022 | Science China(Information Sciences)2022，65，8： | 0 |
| 18 | Al-modification for PS-PVD 7YSZ TBCs to improve particle erosion and thermal cycle performances显示文摘Plasma spray-physical vapor deposition(PS-PVD)as a novel process was used to prepare feather-like columnar thermal barrier coatings(TBCs).This special microstructure shows good strain tolerance and non-line-of-sight(NLOS)deposition,giving great potential application in aero-engine.However,due to serious service environment of aero-engine,particle erosion performance is a weakness for PS-PVD 7YSZ TBCs.As a solution,an Al-modification approach was proposed in this investigation.Through in-situ reaction of Al and ZrO2,anα-Al2O3 overlay can be formed on the surface of 7YSZ columnar coating.The results demonstrate that this approach can improve particle erosion resistance since hardness improvement of Al-modified TBCs.Meanwhile,as another important performance of thermal cycle,it has a better optimization with 350-cycle water-quenching,compared with the as-sprayed TBCs. | Xiaofeng ZHANG Ming LI Ao ZHANG Shuangquan GUO Jie MAO Chunming DENG Panpan WANG Changguang DENG Junli FENG Min LIU Kesong ZHOU Cheng LAI | 2022 | Journal of Advanced Ceramics2022，11，7： | 0 |
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