|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Biodegradation of malathion by Acinetobacter johnsonii MA19 and optimization of cometabolism substrates显示文摘To enhance the removal effciency of malathion in the wastewater from organophosphate pesticide mill,a bacterium,Acinetobacter johnsonii MA19,that could degrade malathion with cometabolism was isolated from malathion-polluted soil samples using enrichment culture techniques. Four kinds of additional compounds,sodium succinate,sodium acetate,glucose,and fructose were tested to choose a favorite carbon source for the cometabolism of strain MA19. The results showed that sodium succinate and sodium acetate could promote malathion biodegradation and cell growth. The investigation results of the effects of sodium succinate concentrations on the malathion biodegradation indicated that the more sodium succinate supplied resulted in quick degradation of malathion and fast cells multiplied. Zero-order kinetic model was appropriate to describe the malathion biodegradation when the concentration of sodium succinate was more than 0.5144 g/L. The degradation rate constant(K) reached the maximum value of 3.5837 mg/(L·h) when the mass ratio of sodium succinate to malathion was 128.6 mg/mg. The aquatic toxicity of the malathion was evaluated using the test organism,Limnodrilus hoffmeisteri. The data obtained suggested that the toxicity of malathion could be ignored after 84 h biodegradation. Our result demonstrates the potential for using bacterium A. johnsonii MA19 for malathion biodegradation and environmental bioremediation when some suitable conventional carbon sources are supplied. | XIE Shan LIU Junxin LI Lin QIAO Chuanling | 2009 | Journal of Environmental Sciences2009，21，1： | 16 |
| 3 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 4 | Cellulose Nanopaper:Fabrication,Functionalization,and Applications显示文摘Cellulose nanopaper has shown great potential in diverse fields including optoelectronic devices,food packaging,biomedical application,and so forth,owing to their various advantages such as good flexibility,tunable light transmittance,high thermal stability,low thermal expansion coefficient,and superior mechanical properties.Herein,recent progress on the fabrication and applications of cellulose nanopaper is summarized and discussed based on the analyses of the latest studies.We begin with a brief introduction of the three types of nanocellulose:cellulose nanocrystals,cellulose nanofibrils and bacterial cellulose,recapitulating their differences in preparation and properties.Then,the main preparation methods of cellulose nanopaper including filtration method and casting method as well as the newly developed technology are systematically elaborated and compared.Furthermore,the advanced applications of cellulose nanopaper including energy storage,electronic devices,water treatment,and high-performance packaging materials were highlighted.Finally,the prospects and ongoing challenges of cellulose nanopaper were summarized. | Wei Liu Kun Liu Haishun Du Ting Zheng Ning Zhang Ting Xu Bo Pang Xinyu Zhang Chuanling Si Kai Zhang | 2022 | Nano-Micro Letters2022，14，6： | 2 |
| 5 | Nanocellulose-Assisted Construction of Multifunctional MXene-Based Aerogels with Engineering Biomimetic Texture for Pressure Sensor and Compressible Electrode显示文摘Multifunctional architecture with intriguing structural design is highly desired for realizing the promising performances in wearable sensors and flexible energy storage devices.Cellulose nanofiber(CNF)is employed for assisting in building conductive,hyperelastic,and ultralight Ti_(3)C_(2)T_(x)MXene hybrid aerogels with oriented tracheid-like texture.The biomimetic hybrid aerogels are constructed by a facile bidirectional freezing strategy with CNF,carbon nanotube(CNT),and MXene based on synergistic electrostatic interaction and hydrogen bonding.Entangled CNF and CNT“mortars”bonded with MXene“bricks”of the tracheid structure produce good interfacial binding,and superior mechanical strength(up to 80%compressibility and extraordinary fatigue resistance of 1000 cycles at 50%strain).Benefiting from the biomimetic texture,CNF/CNT/MXene aerogel shows ultralow density of 7.48 mg cm^(-3)and excellent electrical conductivity(~2400 S m^(-1)).Used as pressure sensors,such aerogels exhibit appealing sensitivity performance with the linear sensitivity up to 817.3 kPa^(-1),which affords their application in monitoring body surface information and detecting human motion.Furthermore,the aerogels can also act as electrode materials of compressive solid-state supercapacitors that reveal satisfactory electrochemical performance(849.2 mF cm^(-2)at 0.8 mA cm^(-2))and superior long cycle compression performance(88%after 10,000 cycles at a compressive strain of 30%). | Ting Xu Qun Song Kun Liu Huayu Liu Junjie Pan Wei Liu Lin Dai Meng Zhang Yaxuan Wang Chuanling Si Haishun Du Kai Zhang | 2023 | Nano-Micro Letters2023，15，7： | 2 |
| 6 | Identification of Ubiquitinated Proteins from Human Multiple Myeloma U266 Cells by Proteomics显示文摘Objective To identify ubiquitinated proteins from complex human multiple myeloma (MM) U266 cells,a malignant disorder of differentiated human B cells.Methods Employing a globally proteomic strategy combining of immunoprecipitation,LC-MS/MS and SCX-LC-MS analysis to identified ubiquitination sites,which were identified by detecting signature peptides containing a GG-tag (114.1 Da) and an LRGG-tag (383.2 Da).Results In total,52 ubiquitinated proteins containing 73 ubiquitination sites of which 14 and 59 sites contained LRGG-tag and GG-tag were identified,respectively.Conclusion Classification analysis by of the proteins identified in the study based on the PANTHER showed that they were associated with multiple functional groups.This suggested the involvement of many endogenous proteins in the ubiquitination in MM. | JIA HongLing LIU ChaoWu GE Feng XIAO ChuanLe LU ChunHua WANG Tong HE QingYu | 2011 | Biomedical and Environmental Sciences2011，24，4： | 2 |
| 7 | Biodegradation of P-nitrophenol and 4-chlorophenol by stenotrophomonas Sp显示文摘 | LIU Zheng CHAO Yang QIAO Chuanling | 2007 | FEMS Microbiology Letters2007，277，2： | 1 |
| 8 | Continued evolution of the Eurasian avian-like H1N1 swine influenza viruses in China显示文摘Animal influenza viruses continue to pose a threat to human public health. The Eurasian avian-like H1N1(EA H1N1) viruses are widespread in pigs throughout Europe and China and have caused human infections in several countries, indicating their pandemic potential. To carefully monitor the evolution of the EA H1N1 viruses in nature, we collected nasal swabs from 103,110pigs in 22 provinces in China between October 2013 and December 2019, and isolated 855 EA H1N1 viruses. Genomic analysis of 319 representative viruses revealed that these EA H1N1 viruses formed eight different genotypes through reassortment with viruses of other lineages circulating in humans and pigs, and two of these genotypes(G4 and G5) were widely distributed in pigs.Animal studies indicated that some strains have become highly pathogenic in mice and highly transmissible in ferrets via respiratory droplets. Moreover, two-thirds of the EA H1N1 viruses reacted poorly with ferret serum antibodies induced by the currently used H1N1 human influenza vaccine, suggesting that existing immunity may not prevent the transmission of the EA H1N1 viruses in humans. Our study reveals the evolution and pandemic potential of EA H1N1 viruses and provides important insights for future pandemic preparedness. | Fei Meng Yan Chen Zuchen Song Qiu Zhong Yijie Zhang Chuanling Qiao Cheng Yan Huihui Kong Liling Liu Chengjun Li Huanliang Yang Hualan Chen | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 9 | Structure and antitumoractivity of a high-molecular-weight polysaccharide fromcultured mycelium of Cordyceps gunnii显示文摘 | ZHU Zhenyuan LIU Nian SI Chuanling | 2012 | Carbohydrate Polymers2012，88，3： | 1 |
| 10 | Sustainable preparation and characterization of thermally stable and functional cellulose nanocrystals and nanofibrils via formic acid hydrolysis显示文摘In this work,a sustainable method to prepare functional cellulose nanocrystals(CNCs)and cellulose nanofibrils(CNFs)using formic acid(FA)(a recoverable organic acid)was established.After FA hydrolysis,the obtained CNCs could be well dispersed in DMAC.Thus,the CNC products and fibrous cellulosic solid residue(FCSR)in DMAC could be easily separated by a conventional centrifugal process,and the collected FCSR could be further fibrillated to CNFs with relatively low-intensity mechanical fibrillation process.The isolated CNC products showed high crystallinity index(about 75%)and excellent thermal stability(with onset thermal degradation temperature of 325℃).Both the resultant CNCs and CNFs showed better dispersibility in DMSO,DMF and DMAC respectively because of the introduction of ester groups on the surface of the products.The presence of surface ester groups could increase the interface compatibility of nanocelluloses with polymeric matrices and enable their applications in reinforcing polymeric matrix materials(e.g.the composite films like PHVB+CNFs). | Haishun Du Chao Liu Dong Wang Yuedong Zhang Guang Yu Chuanling Si Bin Li Xindong Mu Hui Peng | 2017 | Journal of Bioresources and Bioproducts2017，2，1： | 1 |
| 11 | Construction and Application of Knowledge Graph for Quality and Safety Supervision of Transportation Engineering显示文摘Knowledge graph technology play a more and more important role in various fields of industry and academia.This paper firstly introduces the general framework of the knowledge graph construction,which includes three stages:information extraction,knowledge fusion and knowledge processing.In order to improve the efficiency of quality and safety supervision of transportation engineering construction,this paper constructs a knowledge graph by acquiring multi-sources heterogeneous data from supervision of transportation engineering quality and safety.It employs a bottom-up construction strategy and some natural language processing methods to solve the problems of the knowledge extraction for transportation engineering construction.We use the entity relation extraction method to extract the entity triples from the multi-sources heterogeneous data,and then employ knowledge inference to complete the edges in the constructed knowledge graph,finally perform quality evaluation to add the valid triples to the knowledge graph for updating.Subgraph matching technology is also exploited to retrieve the constructed knowledge graph for efficiently acquiring the useful knowledge about the quality and safety of transportation engineering projects.The results show that the constructed knowledge graph provides a practical and valuable tool for the quality and safety supervision of transportation engineering construction. | Sheng Huang Chuanle Liu | 2021 | Journal on Artificial Intelligence2021，3，4： | 0 |
| 12 | A real-world study of immune checkpoint inhibitors in advanced triple-negative breast cancer显示文摘Background:Triple-negative breast cancer(TNBC)is the most aggressive type of breast cancer.Immune checkpoint inhibitors(ICIs)have been widely used to treat various tumors and have changed the landscape of tumor management,but the data from real-world studies of ICIs for TNBC treatment remain limited.The aim of this study was to evaluate the efficacy of ICIs in the treatment of patients with advanced TNBC in a real-world setting and to explore possible correlates.Methods:The clinical data of advanced TNBC patients who received ICI treatment in the Chinese People's Liberation Army(PLA)General Hospital were collected.Treatment responses,outcomes and adverse events(AEs)were assessed.Results:Eighty-one patients were included in the study.The confirmed objective response rate(ORR)was 32.1%,and the disease control rate(DCR)was 64.2%.The median progression-free survival(PFS)was 4.2 months,and the median overall survival(OS)was 11.0 months.PFS and OS were longer in patients who achieved clinical benefit from ICIs and shorter in patients who received later-line ICIs and higher levels of inflammation;specifically,patients with higher TILs had longer PFS.Overall AEs were tolerable.Conclusions:ICIs are effective in the treatment of advanced TNBC,and the adverse reactions are tolerable.A panel of biomarkers including LDH,ALP,and bNLR were identified to predict the efficacies of ICIs in TNBC treatment. | Zheng Zhang Yadi Zhang Chuanling Liu Jiakang Shao Yimeng Chen Yimin Zhu Li Zhang Boyu Qin Ziqing Kong Xixi Wang Yutong Wang Deqin Huang Liqun Liu Yuxin Zhou Ran Tao Zengjie Yang Mei Liu Weihong Zhao | 2023 | Cancer Innovation2023，2，3： | 0 |
| 13 | Biomass-based materials for advanced supercapacitor:principles,progress,and perspectives显示文摘Supercapacitors exhibit considerable potential as energy storage devices due to their high power density,fast charging and discharging abilities,long cycle life,and ecofriendliness.With the increasing environmental concerns associated with synthetic compounds,the use of environment friendly biopolymers to replace conventional petroleum-based materials has been widely studied.Biomass-based materials are biodegradable,renewable,environment friendly and non-toxic.The unique hierarchical nanostructure,excellent mechanical properties and hydrophilicity allow them to be used to create functional conductive materials with precisely controlled structures and different properties.In this review,the latest development of biomass-based supercapacitor materials is reviewed and discussed.This paper describes the physical and chemical properties of various biopolymers and their impact on supercapacitors,as well as the classification and basic principles of supercapacitors.Then,a comprehensive discussion is presented on the utilization of biomass-based materials in supercapacitors and their recent applications across a range of supercapacitor devices.Finally,an overview of the future prospects and challenges pertaining to the utilization of biomass-based materials in supercapacitors is provided. | Yaxuan Wang Ting Xu Kun Liu Meng Zhang Xu-Min Cai Chuanling Si | 2024 | Aggregate2024，5，1： | 0 |
| 14 | Effects of Nitric Oxide on Growth and Sensitivity of Human Glioma A172 Cells to ^(60)Co and X-ray Radiation显示文摘Nitric oxide (NO)has been implicated both in regression and progression of tumors due to its production by both tumor cells and infiltrating lymphocytes. Ionizing radiation causes the regression of tumors, and can augment the production of NO by macrophages in vitro. The authors examined the effect of nitric oxide (NO) generating agent sodium nitroprusside (SNP) on the growth and radiosensitivity of cultured glioma A172 cells to ^60Co or X-ray radiation. | Qiu Rong, Liu Bing, Guo Chuanling, Li Wenjian, Ma Qiufeng and Li Sha | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员